Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi377 – 384ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:Noc_2675
OrganismiNitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107)
Taxonomic identifieri323261 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeNitrosococcus
Proteomesi
  • UP000006838 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalUniRule annotationAdd BLAST21
Transmembranei65 – 85HelicalUniRule annotationAdd BLAST21
Transmembranei144 – 164HelicalUniRule annotationAdd BLAST21
Transmembranei166 – 186HelicalUniRule annotationAdd BLAST21
Transmembranei250 – 270HelicalUniRule annotationAdd BLAST21
Transmembranei276 – 296HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716351 – 597Lipid A export ATP-binding/permease protein MsbAAdd BLAST597

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi323261.Noc_2675

Structurei

3D structure databases

ProteinModelPortaliQ3J7R8
SMRiQ3J7R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 311ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini343 – 579ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1 Bacteria
COG1132 LUCA
KOiK11085
OMAiGDLMNRI
OrthoDBiPOG091H00DB

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR011917 ABC_transpr_lipidA
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR02203 MsbA_lipidA, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51239 MSBA, 1 hit

Sequencei

Sequence statusi: Complete.

Q3J7R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFTPSLNSG LAVYRRLLSY TRPYRWIFAA SIITMAIYAA TETGLAALMK
60 70 80 90 100
PLMDGSFIER DPATIQIIPL LLIGLFVIRG GANFITQYGL KWVARRVVRD
110 120 130 140 150
LREQMFCHLL ALPARYYDQK ASGQLLAKLI YDVEQVSNAA TDAILTIIRD
160 170 180 190 200
SLTILGLLAW MAYLNGLLTL IILVTAPLIA LIIWWVSHRF RRISRKIQNS
210 220 230 240 250
MGDVSQVAQE TIEGHREVKI FGGQTYEAER FDQVNEQNRR QTMKMAATDA
260 270 280 290 300
ISQPVVQLIA VLGLAGVIHL ATRESMLAQI SVGTFISFIT AMMLLLGPVK
310 320 330 340 350
RLTKINGTLQ RGIAAAQSIF GLLAETPEAD RGQQSLRRAR GAIRFEHLSF
360 370 380 390 400
CYEPAKGPVL ENIDLEIKPY QTIALVGHSG SGKSTLVSLL ARFYETTSGR
410 420 430 440 450
ILIDEMDIQT LRLTELRRQI ALVSQQIILF NDTIAHNIAY GSYQQTSKQD
460 470 480 490 500
IIRAAEAAHA MEFINRLPDG LDTVIGEKGV LLSGGQRQRL AIARALLKDA
510 520 530 540 550
PILILDEATA SLDTEAERHI QAALETLMRQ RTTLVIAHRL STVENADQII
560 570 580 590
VLHQGQIIER GTHSQLLARE SHYAGLYRLQ FRHSHEHVSP LSANVGL
Length:597
Mass (Da):66,459
Last modified:November 8, 2005 - v1
Checksum:iC2F6440E39DCE632
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000127 Genomic DNA Translation: ABA59128.1
RefSeqiWP_011331031.1, NC_007484.1

Genome annotation databases

EnsemblBacteriaiABA59128; ABA59128; Noc_2675
KEGGinoc:Noc_2675

Similar proteinsi

Entry informationi

Entry nameiMSBA_NITOC
AccessioniPrimary (citable) accession number: Q3J7R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health