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Protein

Chemotaxis response regulator protein-glutamate methylesterase 1

Gene

cheB1

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei183UniRule annotation1
Active sitei209UniRule annotation1
Active sitei305UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 1UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB1UniRule annotation
Ordered Locus Names:RHOS4_01630
ORF Names:RSP_1588
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002254811 – 369Chemotaxis response regulator protein-glutamate methylesterase 1Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei624-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_1588

Structurei

3D structure databases

ProteinModelPortaliQ3J653
SMRiQ3J653
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 128Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini170 – 363CheB-type methylesteraseUniRule annotationAdd BLAST194

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP Bacteria
COG2201 LUCA
HOGENOMiHOG000151423
KOiK03412
OMAiHAMAQTT
OrthoDBiPOG091H045J
PhylomeDBiQ3J653

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q3J653-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTHAAAPST RVLIVDDSAA ARAMFKVIVE SDPALQVMAA VPDAFAAARA
60 70 80 90 100
MRTELPDVIL LDLELPGMDG LTFLRKIMQQ HPIPVVVCSS HVGAGTEAMV
110 120 130 140 150
SALELGAREV ISKPAARNDL ERQEASIRIC DAIRAATETT RRRSQPEPRP
160 170 180 190 200
LAPGPKLTAD EILPARPPRP VPETMPVVCI GASTGGTEAL RDVLTALPAS
210 220 230 240 250
APPIVIVQHM PRGFTAAFAR RLDSLCAIEV LEAEDEMQVM PGRAIIAQGD
260 270 280 290 300
RHLLLRRRNQ GYRVSVLDGA YVCRHRPSVD VLFRSAAQEA GGNALGVIMT
310 320 330 340 350
GMGDDGARCM AEMRAAGAET IAQNEESCVV YGMPREAVAH GGVGKVEPLD
360
RLAARIMEFG RRHTERTVR
Length:369
Mass (Da):39,605
Last modified:November 8, 2005 - v1
Checksum:i304F844CA7EB83C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA Translation: ABA77731.1
RefSeqiWP_011336855.1, NZ_AKVW01000001.1
YP_351632.1, NC_007493.2

Genome annotation databases

EnsemblBacteriaiABA77731; ABA77731; RSP_1588
GeneIDi3718577
KEGGirsp:RSP_1588
PATRICifig|272943.9.peg.465

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA Translation: ABA77731.1
RefSeqiWP_011336855.1, NZ_AKVW01000001.1
YP_351632.1, NC_007493.2

3D structure databases

ProteinModelPortaliQ3J653
SMRiQ3J653
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272943.RSP_1588

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA77731; ABA77731; RSP_1588
GeneIDi3718577
KEGGirsp:RSP_1588
PATRICifig|272943.9.peg.465

Phylogenomic databases

eggNOGiENOG4105CMP Bacteria
COG2201 LUCA
HOGENOMiHOG000151423
KOiK03412
OMAiHAMAQTT
OrthoDBiPOG091H045J
PhylomeDBiQ3J653

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCHEB1_RHOS4
AccessioniPrimary (citable) accession number: Q3J653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 8, 2005
Last modified: October 10, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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