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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. no protein annotated in this organism
  4. Fructose-1,6-bisphosphate aldolase (fbaA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei353Proton donorUniRule annotation1
Active sitei384UniRule annotation1
Active sitei512UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00181

UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:PSHAa1139
OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
Taxonomic identifieri326442 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
Proteomesi
  • UP000006843 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002309271 – 548Glucose-6-phosphate isomeraseAdd BLAST548

Interactioni

Protein-protein interaction databases

STRINGi326442.PSHAa1139

Structurei

3D structure databases

ProteinModelPortaliQ3IKH4
SMRiQ3IKH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP8 Bacteria
COG0166 LUCA
HOGENOMiHOG000261370
KOiK01810
OMAiVERCKAM
OrthoDBiPOG091H04C3

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q3IKH4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNRSQLASW QALEKSATKM KQSHLRDLFA KDDARFSQFS TQIPGLLFDY
60 70 80 90 100
SKQRIDKDVF TQLIALAKEC DISAWREKMF NGEKINITEN RAVLHTALRN
110 120 130 140 150
RAHTPLIVDG ENVTELVDNE LAKIKLFVEK VRSGKWLGYS GKPVKDVVSI
160 170 180 190 200
GVGGSNLGPQ MATEALKALS DDTLNVHYVS NADGVQIASV LKNIDAETTL
210 220 230 240 250
FVIASKTFTT SETMTNAKTA VDWFLQTAKD NAAIAKHFVA VSTNLEKTAE
260 270 280 290 300
FGISNDNVFT MWDWVGGRFS LWSAIGLPIA LYAGYDAFEA ILEGAYEVDE
310 320 330 340 350
HFKNAPLEQN IPLIMALLSV WNTSFLGYTS QAILPYDQAL HMLPAYLQQG
360 370 380 390 400
EMESNGKHVN FAGETVPYTT VPIIWGMTGI NGQHAFYQCL HQGNVIVPAD
410 420 430 440 450
FIASIKPQVN VDKHHDILLS NFFAQTEALM NGVDEQEITA DLTAKGKSQA
460 470 480 490 500
QIDELLKHKI HQGNRPTTSM LLDSVDAKTV GRLIALYEHK IFCQGIILEI
510 520 530 540
CSFDQWGVEL GKGLASKIEA ELVDERVKYA HDSSTNGLMA YYKQHRTQ
Length:548
Mass (Da):60,901
Last modified:November 8, 2005 - v1
Checksum:iCEBB7BDA906A5C51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR954246 Genomic DNA Translation: CAI86214.1
RefSeqiWP_011327825.1, NC_007481.1

Genome annotation databases

EnsemblBacteriaiCAI86214; CAI86214; PSHAa1139
KEGGipha:PSHAa1139
PATRICifig|326442.8.peg.1096

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR954246 Genomic DNA Translation: CAI86214.1
RefSeqiWP_011327825.1, NC_007481.1

3D structure databases

ProteinModelPortaliQ3IKH4
SMRiQ3IKH4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326442.PSHAa1139

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI86214; CAI86214; PSHAa1139
KEGGipha:PSHAa1139
PATRICifig|326442.8.peg.1096

Phylogenomic databases

eggNOGiENOG4107QP8 Bacteria
COG0166 LUCA
HOGENOMiHOG000261370
KOiK01810
OMAiVERCKAM
OrthoDBiPOG091H04C3

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00181

UPA00138

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_PSEHT
AccessioniPrimary (citable) accession number: Q3IKH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 8, 2005
Last modified: October 10, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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