Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 69 (07 Oct 2020)
Sequence version 1 (14 Apr 2009)
Previous versions | rss
Add a publicationFeedback
Protein

DNA topoisomerase I

Gene

H6R

Organism
Monkeypox virus
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.UniRule annotation EC:5.6.2.1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotationARBA annotation, Isomerase, TopoisomeraseUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA topoisomerase IUniRule annotationARBA annotation (EC:5.6.2.1UniRule annotation)
Alternative name(s):
DNA topoisomerase 1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:H6RImported
ORF Names:MPXV-CAM1990_02-088Imported, MPXV-Congo_8-089Imported, MPXV-GAB1988_001-089Imported, MPXV-Ikubi-088Imported, MPXV_DRC_Yandongi_097Imported, MPXV_RCG2003_358_101Imported, MPXV_ROC_2010_040Imported, MPXV_ZAI1979_005_101Imported, MPXVgp096Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMonkeypox virusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10244 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesVaridnaviriaBamfordviraeNucleocytoviricotaPokkesviricetesChitoviralesPoxviridaeChordopoxvirinaeOrthopoxvirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiCynomys gunnisoni (Gunnison's prairie dog) [TaxID: 45479]
Cynomys leucurus (White-tailed prairie dog) [TaxID: 99825]
Cynomys ludovicianus (Black-tailed prairie dog) [TaxID: 45480]
Cynomys mexicanus (Mexican prairie dog) [TaxID: 99826]
Cynomys parvidens (Utah prairie dog) [TaxID: 99827]
Gliridae (dormice) [TaxID: 30650]
Heliosciurus ruwenzorii (Ruwenzori sun squirrel) [TaxID: 226685]
Homo sapiens (Human) [TaxID: 9606]
Mus musculus (Mouse) [TaxID: 10090]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Keywords - Developmental stagei

Late proteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 61VirDNA-topo-I_NInterPro annotationAdd BLAST58
Domaini93 – 278Topoisom_IInterPro annotationAdd BLAST186

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type IB topoisomerase family.UniRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00659, Topo_IB_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.380, 1 hit
3.30.66.10, 1 hit
3.90.15.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011010, DNA_brk_join_enz
IPR035447, DNA_topo_I_N
IPR001631, TopoI
IPR018521, TopoI_AS
IPR027362, TopoI_C
IPR014711, TopoI_cat_a-hlx-sub_euk
IPR013500, TopoI_cat_euk
IPR015346, TopoI_N_vir

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01028, Topoisom_I, 1 hit
PF09266, VirDNA-topo-I_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00416, EUTPISMRASEI

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55869, SSF55869, 1 hit
SSF56349, SSF56349, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00176, TOPOISOMERASE_I_EUK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3I8R8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRALFYKDGK LFTDNNFLNP VSDDNPAYEV LQHVKIPTHL TDVVVYEQTW
60 70 80 90 100
EEALTRLIFV GSDSKGRRQY FYGKMHVQNR NAKRDRIFVR VYNVMKRINC
110 120 130 140 150
FINKNIKKSS TDSNYQLAVF MLMETMFFIR FGKMKYLKEN ETVGLLTLKN
160 170 180 190 200
KHIEISPDEI VIKFVGKDKV SHEFVVHKSN RLYKPLLKLT DDSSPEEFLF
210 220 230 240 250
NKLSERKVYE CIKQFGIRIK DLRTYGVNYT FLYNFWTNVK SVSPLPSPKK
260 270 280 290 300
LIALTIKQTA EVVGHTPSIS KRAYMATTIL EMVKDKNFLD VVSKTTFDEF
310
LSIVVDHVKS STDG
Length:314
Mass (Da):36,652
Last modified:April 14, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFD41FE404869D27
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ011154 Genomic DNA Translation: AAY97095.1
DQ011155 Genomic DNA Translation: AAY97296.1
HM172544 Genomic DNA Translation: ADK39121.1
KC257460 Genomic DNA Translation: AGF36859.1
KC257461 Genomic DNA Translation: AGF37000.1
JX878407 Genomic DNA Translation: AGR34457.1
JX878408 Genomic DNA Translation: AGR34647.1
JX878409 Genomic DNA Translation: AGR34838.1
JX878410 Genomic DNA Translation: AGR35029.1
JX878411 Genomic DNA Translation: AGR35220.1
JX878412 Genomic DNA Translation: AGR35411.1
JX878413 Genomic DNA Translation: AGR35602.1
JX878414 Genomic DNA Translation: AGR35793.1
JX878415 Genomic DNA Translation: AGR35984.1
JX878416 Genomic DNA Translation: AGR36175.1
JX878417 Genomic DNA Translation: AGR36366.1
JX878418 Genomic DNA Translation: AGR36557.1
JX878419 Genomic DNA Translation: AGR36748.1
JX878420 Genomic DNA Translation: AGR36939.1
JX878421 Genomic DNA Translation: AGR37130.1
JX878422 Genomic DNA Translation: AGR37321.1
JX878423 Genomic DNA Translation: AGR37512.1
JX878424 Genomic DNA Translation: AGR37702.1
JX878425 Genomic DNA Translation: AGR37892.1
JX878426 Genomic DNA Translation: AGR38082.1
JX878427 Genomic DNA Translation: AGR38273.1
JX878428 Genomic DNA Translation: AGR38464.1
JX878429 Genomic DNA Translation: AGR38655.1
KJ642612 Genomic DNA Translation: AIE40181.1
KJ642613 Genomic DNA Translation: AIE40359.1
KJ642618 Genomic DNA Translation: AIE41238.1
KJ642619 Genomic DNA Translation: AIE41416.1
KP849469 Genomic DNA Translation: AKG51071.1
KP849471 Genomic DNA Translation: AKG51444.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ011154 Genomic DNA Translation: AAY97095.1
DQ011155 Genomic DNA Translation: AAY97296.1
HM172544 Genomic DNA Translation: ADK39121.1
KC257460 Genomic DNA Translation: AGF36859.1
KC257461 Genomic DNA Translation: AGF37000.1
JX878407 Genomic DNA Translation: AGR34457.1
JX878408 Genomic DNA Translation: AGR34647.1
JX878409 Genomic DNA Translation: AGR34838.1
JX878410 Genomic DNA Translation: AGR35029.1
JX878411 Genomic DNA Translation: AGR35220.1
JX878412 Genomic DNA Translation: AGR35411.1
JX878413 Genomic DNA Translation: AGR35602.1
JX878414 Genomic DNA Translation: AGR35793.1
JX878415 Genomic DNA Translation: AGR35984.1
JX878416 Genomic DNA Translation: AGR36175.1
JX878417 Genomic DNA Translation: AGR36366.1
JX878418 Genomic DNA Translation: AGR36557.1
JX878419 Genomic DNA Translation: AGR36748.1
JX878420 Genomic DNA Translation: AGR36939.1
JX878421 Genomic DNA Translation: AGR37130.1
JX878422 Genomic DNA Translation: AGR37321.1
JX878423 Genomic DNA Translation: AGR37512.1
JX878424 Genomic DNA Translation: AGR37702.1
JX878425 Genomic DNA Translation: AGR37892.1
JX878426 Genomic DNA Translation: AGR38082.1
JX878427 Genomic DNA Translation: AGR38273.1
JX878428 Genomic DNA Translation: AGR38464.1
JX878429 Genomic DNA Translation: AGR38655.1
KJ642612 Genomic DNA Translation: AIE40181.1
KJ642613 Genomic DNA Translation: AIE40359.1
KJ642618 Genomic DNA Translation: AIE41238.1
KJ642619 Genomic DNA Translation: AIE41416.1
KP849469 Genomic DNA Translation: AKG51071.1
KP849471 Genomic DNA Translation: AKG51444.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd00659, Topo_IB_C, 1 hit
Gene3Di1.20.120.380, 1 hit
3.30.66.10, 1 hit
3.90.15.10, 1 hit
InterProiView protein in InterPro
IPR011010, DNA_brk_join_enz
IPR035447, DNA_topo_I_N
IPR001631, TopoI
IPR018521, TopoI_AS
IPR027362, TopoI_C
IPR014711, TopoI_cat_a-hlx-sub_euk
IPR013500, TopoI_cat_euk
IPR015346, TopoI_N_vir
PfamiView protein in Pfam
PF01028, Topoisom_I, 1 hit
PF09266, VirDNA-topo-I_N, 1 hit
PRINTSiPR00416, EUTPISMRASEI
SUPFAMiSSF55869, SSF55869, 1 hit
SSF56349, SSF56349, 1 hit
PROSITEiView protein in PROSITE
PS00176, TOPOISOMERASE_I_EUK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3I8R8_MONPV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3I8R8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 14, 2009
Last sequence update: April 14, 2009
Last modified: October 7, 2020
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again