UniProtKB - Q3I5F7 (ACOT6_HUMAN)
Protein
Putative acyl-coenzyme A thioesterase 6
Gene
ACOT6
Organism
Homo sapiens (Human)
Status
Functioni
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). It is unclear if human acyl-coenzyme A thioesterase 6/ACOT6 has an acyl-CoA thioesterase (Probable).1 Publication1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 18 | Charge relay systemSequence analysis | 1 | |
Active sitei | 112 | Charge relay systemSequence analysis | 1 | |
Active sitei | 146 | Charge relay systemSequence analysis | 1 |
GO - Molecular functioni
- acyl-CoA hydrolase activity Source: GO_Central
- carboxylic ester hydrolase activity Source: UniProtKB-KW
GO - Biological processi
- acyl-CoA metabolic process Source: GO_Central
- fatty acid metabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Serine esterase |
Enzyme and pathway databases
BRENDAi | 3.1.2.20, 2681 |
PathwayCommonsi | Q3I5F7 |
Reactomei | R-HSA-390247, Beta-oxidation of very long chain fatty acids |
Protein family/group databases
ESTHERi | human-ACOT6, Acyl-CoA_Thioesterase |
MEROPSi | S09.944 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative acyl-coenzyme A thioesterase 6 (EC:3.1.2.-Curated)Short name: Putative acyl-CoA thioesterase 6 |
Gene namesi | Name:ACOT6 Synonyms:C14orf42 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33159, ACOT6 |
MIMi | 614267, gene |
neXtProti | NX_Q3I5F7 |
VEuPathDBi | HostDB:ENSG00000205669.2 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: HGNC-UCL
Peroxisome
- peroxisomal matrix Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 641372 |
OpenTargetsi | ENSG00000205669 |
PharmGKBi | PA162375329 |
Miscellaneous databases
Pharosi | Q3I5F7, Tdark |
Genetic variation databases
BioMutai | ACOT6 |
DMDMi | 121942509 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305098 | 1 – 207 | Putative acyl-coenzyme A thioesterase 6Add BLAST | 207 |
Proteomic databases
MassIVEi | Q3I5F7 |
PaxDbi | Q3I5F7 |
PeptideAtlasi | Q3I5F7 |
PRIDEi | Q3I5F7 |
ProteomicsDBi | 61691 |
PTM databases
iPTMneti | Q3I5F7 |
PhosphoSitePlusi | Q3I5F7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000205669, Expressed in right lobe of liver and 67 other tissues |
ExpressionAtlasi | Q3I5F7, baseline and differential |
Genevisiblei | Q3I5F7, HS |
Organism-specific databases
HPAi | ENSG00000205669, Tissue enhanced (kidney, liver, skeletal muscle) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 534966, 2 interactors |
IntActi | Q3I5F7, 2 interactors |
STRINGi | 9606.ENSP00000370531 |
Miscellaneous databases
RNActi | Q3I5F7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the C/M/P thioester hydrolase family.Curated
Phylogenomic databases
eggNOGi | ENOG502QQ8Z, Eukaryota |
GeneTreei | ENSGT01010000222504 |
HOGENOMi | CLU_029849_4_1_1 |
InParanoidi | Q3I5F7 |
OMAi | NCQSLIP |
OrthoDBi | 1260385at2759 |
PhylomeDBi | Q3I5F7 |
TreeFami | TF314911 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR014940, BAAT_C |
Pfami | View protein in Pfam PF08840, BAAT_C, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q3I5F7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLQHPKVKGP SIALLGFSKG GDLCLSMASF LKGITATVLI NACVANTVAP
60 70 80 90 100
LHYKDMIIPK LVDDLGKVKI TKSGFLTFMD TWSNPLEEHN HQSLVPLEKA
110 120 130 140 150
QVPFLFIVGM DDQSWKSEFY AQIASERLQA HGKERPQIIC YPETGHCIDP
160 170 180 190 200
PYFPPSRASV HAVLGEAIFY GGEPKAHSKA QVDAWQQIQT FFHKHLNGKK
SVKHSKI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y7H3 | A0A2R8Y7H3_HUMAN | Putative acyl-coenzyme A thioestera... | ACOT6 | 421 | Annotation score: | ||
G3V3W6 | G3V3W6_HUMAN | Putative acyl-coenzyme A thioestera... | ACOT6 | 168 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052302 | 166 | E → K. Corresponds to variant dbSNP:rs17782052Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ082756 mRNA Translation: AAZ31238.1 BC126378 mRNA Translation: AAI26379.1 BC126380 mRNA Translation: AAI26381.1 |
CCDSi | CCDS32118.1 |
RefSeqi | NP_001032239.1, NM_001037162.1 |
Genome annotation databases
Ensembli | ENST00000381139; ENSP00000370531; ENSG00000205669 |
GeneIDi | 641372 |
KEGGi | hsa:641372 |
UCSCi | uc001xop.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ082756 mRNA Translation: AAZ31238.1 BC126378 mRNA Translation: AAI26379.1 BC126380 mRNA Translation: AAI26381.1 |
CCDSi | CCDS32118.1 |
RefSeqi | NP_001032239.1, NM_001037162.1 |
3D structure databases
SMRi | Q3I5F7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 534966, 2 interactors |
IntActi | Q3I5F7, 2 interactors |
STRINGi | 9606.ENSP00000370531 |
Protein family/group databases
ESTHERi | human-ACOT6, Acyl-CoA_Thioesterase |
MEROPSi | S09.944 |
PTM databases
iPTMneti | Q3I5F7 |
PhosphoSitePlusi | Q3I5F7 |
Genetic variation databases
BioMutai | ACOT6 |
DMDMi | 121942509 |
Proteomic databases
MassIVEi | Q3I5F7 |
PaxDbi | Q3I5F7 |
PeptideAtlasi | Q3I5F7 |
PRIDEi | Q3I5F7 |
ProteomicsDBi | 61691 |
Protocols and materials databases
Antibodypediai | 63322, 44 antibodies |
DNASUi | 641372 |
Genome annotation databases
Ensembli | ENST00000381139; ENSP00000370531; ENSG00000205669 |
GeneIDi | 641372 |
KEGGi | hsa:641372 |
UCSCi | uc001xop.3, human |
Organism-specific databases
CTDi | 641372 |
DisGeNETi | 641372 |
GeneCardsi | ACOT6 |
HGNCi | HGNC:33159, ACOT6 |
HPAi | ENSG00000205669, Tissue enhanced (kidney, liver, skeletal muscle) |
MIMi | 614267, gene |
neXtProti | NX_Q3I5F7 |
OpenTargetsi | ENSG00000205669 |
PharmGKBi | PA162375329 |
VEuPathDBi | HostDB:ENSG00000205669.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ8Z, Eukaryota |
GeneTreei | ENSGT01010000222504 |
HOGENOMi | CLU_029849_4_1_1 |
InParanoidi | Q3I5F7 |
OMAi | NCQSLIP |
OrthoDBi | 1260385at2759 |
PhylomeDBi | Q3I5F7 |
TreeFami | TF314911 |
Enzyme and pathway databases
BRENDAi | 3.1.2.20, 2681 |
PathwayCommonsi | Q3I5F7 |
Reactomei | R-HSA-390247, Beta-oxidation of very long chain fatty acids |
Miscellaneous databases
BioGRID-ORCSi | 641372, 7 hits in 985 CRISPR screens |
ChiTaRSi | ACOT6, human |
GenomeRNAii | 641372 |
Pharosi | Q3I5F7, Tdark |
PROi | PR:Q3I5F7 |
RNActi | Q3I5F7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000205669, Expressed in right lobe of liver and 67 other tissues |
ExpressionAtlasi | Q3I5F7, baseline and differential |
Genevisiblei | Q3I5F7, HS |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR014940, BAAT_C |
Pfami | View protein in Pfam PF08840, BAAT_C, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACOT6_HUMAN | |
Accessioni | Q3I5F7Primary (citable) accession number: Q3I5F7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | November 8, 2005 | |
Last modified: | April 7, 2021 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families