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UniProtKB - Q3I5F7 (ACOT6_HUMAN)

Entry version 101 (26 Feb 2020)
Sequence version 1 (08 Nov 2005)
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Protein

Putative acyl-coenzyme A thioesterase 6

Gene

ACOT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). It is unclear if human acyl-coenzyme A thioesterase 6/ACOT6 has an acyl-CoA thioesterase (Probable).1 Publication1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei18Charge relay systemSequence analysis1
Active sitei112Charge relay systemSequence analysis1
Active sitei146Charge relay systemSequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.2.20 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390247 Beta-oxidation of very long chain fatty acids

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...ESTHERi		human-ACOT6 Acyl-CoA_Thioesterase

MEROPS protease database

More...MEROPSi		S09.944

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative acyl-coenzyme A thioesterase 6 (EC:3.1.2.-Curated)
Short name:
Putative acyl-CoA thioesterase 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACOT6
Synonyms:C14orf42
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:33159 ACOT6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614267 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q3I5F7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		641372

Open Targets

More...OpenTargetsi		ENSG00000205669

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162375329

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q3I5F7 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ACOT6

Domain mapping of disease mutations (DMDM)

More...DMDMi		121942509

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003050981 – 207Putative acyl-coenzyme A thioesterase 6Add BLAST207

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q3I5F7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q3I5F7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3I5F7

PeptideAtlas

More...PeptideAtlasi		Q3I5F7

PRoteomics IDEntifications database

More...PRIDEi		Q3I5F7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61691

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q3I5F7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q3I5F7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000205669 Expressed in right lobe of liver and 54 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q3I5F7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q3I5F7 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA058258

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		534966, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q3I5F7, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000370531

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q3I5F7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q3I5F7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the C/M/P thioester hydrolase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410II3X Eukaryota
COG1073 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182784

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_029849_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q3I5F7

KEGG Orthology (KO)

More...KOi		K11993

Identification of Orthologs from Complete Genome Data

More...OMAi		NCQSLIP

Database of Orthologous Groups

More...OrthoDBi		1260385at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q3I5F7

TreeFam database of animal gene trees

More...TreeFami		TF314911

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029058 AB_hydrolase
IPR014940 BAAT_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08840 BAAT_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q3I5F7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQHPKVKGP SIALLGFSKG GDLCLSMASF LKGITATVLI NACVANTVAP 
        60         70         80         90        100
LHYKDMIIPK LVDDLGKVKI TKSGFLTFMD TWSNPLEEHN HQSLVPLEKA 
       110        120        130        140        150
QVPFLFIVGM DDQSWKSEFY AQIASERLQA HGKERPQIIC YPETGHCIDP 
       160        170        180        190        200
PYFPPSRASV HAVLGEAIFY GGEPKAHSKA QVDAWQQIQT FFHKHLNGKK 

SVKHSKI
Length:207
Mass (Da):22,991
Last modified:November 8, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB77AB1DC5760D306
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y7H3A0A2R8Y7H3_HUMAN
Putative acyl-coenzyme A thioestera...
ACOT6
421Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3W6G3V3W6_HUMAN
Putative acyl-coenzyme A thioestera...
ACOT6
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052302166E → K. Corresponds to variant dbSNP:rs17782052Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ082756 mRNA Translation: AAZ31238.1
BC126378 mRNA Translation: AAI26379.1
BC126380 mRNA Translation: AAI26381.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32118.1

NCBI Reference Sequences

More...RefSeqi		NP_001032239.1, NM_001037162.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000381139; ENSP00000370531; ENSG00000205669

Database of genes from NCBI RefSeq genomes

More...GeneIDi		641372

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:641372

UCSC genome browser

More...UCSCi		uc001xop.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ082756 mRNA Translation: AAZ31238.1
BC126378 mRNA Translation: AAI26379.1
BC126380 mRNA Translation: AAI26381.1
CCDSiCCDS32118.1
RefSeqiNP_001032239.1, NM_001037162.1

3D structure databases

SMRiQ3I5F7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi534966, 2 interactors
IntActiQ3I5F7, 2 interactors
STRINGi9606.ENSP00000370531

Protein family/group databases

ESTHERihuman-ACOT6 Acyl-CoA_Thioesterase
MEROPSiS09.944

PTM databases

iPTMnetiQ3I5F7
PhosphoSitePlusiQ3I5F7

Polymorphism and mutation databases

BioMutaiACOT6
DMDMi121942509

Proteomic databases

jPOSTiQ3I5F7
MassIVEiQ3I5F7
PaxDbiQ3I5F7
PeptideAtlasiQ3I5F7
PRIDEiQ3I5F7
ProteomicsDBi61691

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		641372

Genome annotation databases

EnsembliENST00000381139; ENSP00000370531; ENSG00000205669
GeneIDi641372
KEGGihsa:641372
UCSCiuc001xop.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		641372
DisGeNETi641372

GeneCards: human genes, protein and diseases

More...GeneCardsi		ACOT6
HGNCiHGNC:33159 ACOT6
HPAiHPA058258
MIMi614267 gene
neXtProtiNX_Q3I5F7
OpenTargetsiENSG00000205669
PharmGKBiPA162375329

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410II3X Eukaryota
COG1073 LUCA
GeneTreeiENSGT00950000182784
HOGENOMiCLU_029849_4_1_1
InParanoidiQ3I5F7
KOiK11993
OMAiNCQSLIP
OrthoDBi1260385at2759
PhylomeDBiQ3I5F7
TreeFamiTF314911

Enzyme and pathway databases

BRENDAi3.1.2.20 2681
ReactomeiR-HSA-390247 Beta-oxidation of very long chain fatty acids

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ACOT6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		641372
PharosiQ3I5F7 Tdark

Protein Ontology

More...PROi		PR:Q3I5F7
RNActiQ3I5F7 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000205669 Expressed in right lobe of liver and 54 other tissues
ExpressionAtlasiQ3I5F7 baseline and differential
GenevisibleiQ3I5F7 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR014940 BAAT_C
PfamiView protein in Pfam
PF08840 BAAT_C, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACOT6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3I5F7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 8, 2005
Last modified: February 26, 2020
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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