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Entry version 127 (02 Jun 2021)
Sequence version 2 (10 Jan 2006)
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Protein

2-phytyl-1,4-beta-naphthoquinone methyltransferase, chloroplastic

Gene

MENG

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the biosynthesis of phylloquinone (vitamin K1). Methyltransferase required for the conversion of 2-phytyl-1,4-beta-naphthoquinol to phylloquinol.

UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 2-phytyl-1,4-naphthoquinone methyltransferase activity Source: TAIR
  • methyltransferase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:AT1G23360-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.329, 399

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2-phytyl-1,4-beta-naphthoquinone methyltransferase, chloroplasticUniRule annotation (EC:2.1.1.329UniRule annotation)
Alternative name(s):
Demethylphylloquinone methyltransferaseUniRule annotation
Menaquinone biosynthesis methyltransferase ubiE-like proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MENGUniRule annotation
Ordered Locus Names:At1g23360
ORF Names:F26F24.24
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G23360

The Arabidopsis Information Resource

More...
TAIRi
locus:2028050, AT1G23360

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chloroplast, Plastid

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Lack of phylloquinone and reduced growth under normal light. Loss of anthocyanin accumulation under high light.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 30ChloroplastUniRule annotationAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000040698631 – 2612-phytyl-1,4-beta-naphthoquinone methyltransferase, chloroplasticAdd BLAST231

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3ED65

PRoteomics IDEntifications database

More...
PRIDEi
Q3ED65

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
232229 [Q3ED65-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3ED65

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3ED65, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3ED65, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G23360.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3ED65

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1540, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037990_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3ED65

Identification of Orthologs from Complete Genome Data

More...
OMAi
WQKSALN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3ED65

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01982, MenG_phylloquinone_subfam, 1 hit
MF_01813, MenG_UbiE_methyltr, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032904, MenG
IPR029063, SAM-dependent_MTases
IPR004033, UbiE/COQ5_MeTrFase
IPR023576, UbiE/COQ5_MeTrFase_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01209, Ubie_methyltran, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01934, MenG_MenH_UbiE, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51608, SAM_MT_UBIE, 1 hit
PS01183, UBIE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3ED65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALLGIVSP VTFTGKHPVN SRSRRRTVVK CSNERRILFN RIAPVYDNLN
60 70 80 90 100
DLLSLGQHRI WKNMAVSWSG AKKGDYVLDL CCGSGDLAFL LSEKVGSTGK
110 120 130 140 150
VMGLDFSSEQ LAVAATRQSL KARSCYKCIE WIEGDAIDLP FDDCEFDAVT
160 170 180 190 200
MGYGLRNVVD RLRAMKEMYR VLKPGSRVSI LDFNKSNQSV TTFMQGWMID
210 220 230 240 250
NVVVPVATVY DLAKEYEYLK YSINGYLTGE ELETLALEAG FSSACHYEIS
260
GGFMGNLVAM R
Length:261
Mass (Da):29,051
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i933A722FD246F1EE
GO
Isoform 2 (identifier: Q3ED65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Show »
Length:160
Mass (Da):17,964
Checksum:iDDFAFA0FABF7157D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF79599 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF87008 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0409141 – 101Missing in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC005292 Genomic DNA Translation: AAF87008.1 Sequence problems.
AC007945 Genomic DNA Translation: AAF79599.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE30377.1
CP002684 Genomic DNA Translation: AEE30378.1
CP002684 Genomic DNA Translation: AEE30379.1
BT014858 mRNA Translation: AAT41841.1
AK317221 mRNA Translation: BAH19903.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F86367

NCBI Reference Sequences

More...
RefSeqi
NP_173750.3, NM_102185.4 [Q3ED65-1]
NP_973894.1, NM_202165.1 [Q3ED65-2]
NP_973895.1, NM_202166.2 [Q3ED65-2]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G23360.1; AT1G23360.1; AT1G23360 [Q3ED65-1]
AT1G23360.2; AT1G23360.2; AT1G23360 [Q3ED65-2]
AT1G23360.3; AT1G23360.3; AT1G23360 [Q3ED65-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
838945

Gramene; a comparative resource for plants

More...
Gramenei
AT1G23360.1; AT1G23360.1; AT1G23360 [Q3ED65-1]
AT1G23360.2; AT1G23360.2; AT1G23360 [Q3ED65-2]
AT1G23360.3; AT1G23360.3; AT1G23360 [Q3ED65-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G23360

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005292 Genomic DNA Translation: AAF87008.1 Sequence problems.
AC007945 Genomic DNA Translation: AAF79599.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE30377.1
CP002684 Genomic DNA Translation: AEE30378.1
CP002684 Genomic DNA Translation: AEE30379.1
BT014858 mRNA Translation: AAT41841.1
AK317221 mRNA Translation: BAH19903.1
PIRiF86367
RefSeqiNP_173750.3, NM_102185.4 [Q3ED65-1]
NP_973894.1, NM_202165.1 [Q3ED65-2]
NP_973895.1, NM_202166.2 [Q3ED65-2]

3D structure databases

SMRiQ3ED65
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G23360.1

PTM databases

iPTMnetiQ3ED65

Proteomic databases

PaxDbiQ3ED65
PRIDEiQ3ED65
ProteomicsDBi232229 [Q3ED65-1]

Genome annotation databases

EnsemblPlantsiAT1G23360.1; AT1G23360.1; AT1G23360 [Q3ED65-1]
AT1G23360.2; AT1G23360.2; AT1G23360 [Q3ED65-2]
AT1G23360.3; AT1G23360.3; AT1G23360 [Q3ED65-2]
GeneIDi838945
GrameneiAT1G23360.1; AT1G23360.1; AT1G23360 [Q3ED65-1]
AT1G23360.2; AT1G23360.2; AT1G23360 [Q3ED65-2]
AT1G23360.3; AT1G23360.3; AT1G23360 [Q3ED65-2]
KEGGiath:AT1G23360

Organism-specific databases

AraportiAT1G23360
TAIRilocus:2028050, AT1G23360

Phylogenomic databases

eggNOGiKOG1540, Eukaryota
HOGENOMiCLU_037990_0_0_1
InParanoidiQ3ED65
OMAiWQKSALN
PhylomeDBiQ3ED65

Enzyme and pathway databases

BioCyciARA:AT1G23360-MONOMER
BRENDAi2.1.1.329, 399

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q3ED65

Gene expression databases

ExpressionAtlasiQ3ED65, baseline and differential
GenevisibleiQ3ED65, AT

Family and domain databases

HAMAPiMF_01982, MenG_phylloquinone_subfam, 1 hit
MF_01813, MenG_UbiE_methyltr, 1 hit
InterProiView protein in InterPro
IPR032904, MenG
IPR029063, SAM-dependent_MTases
IPR004033, UbiE/COQ5_MeTrFase
IPR023576, UbiE/COQ5_MeTrFase_CS
PfamiView protein in Pfam
PF01209, Ubie_methyltran, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
TIGRFAMsiTIGR01934, MenG_MenH_UbiE, 1 hit
PROSITEiView protein in PROSITE
PS51608, SAM_MT_UBIE, 1 hit
PS01183, UBIE_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMENG_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3ED65
Secondary accession number(s): Q6ID15, Q9LQD5, Q9LR22
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: January 10, 2006
Last modified: June 2, 2021
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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