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Entry version 88 (12 Aug 2020)
Sequence version 1 (08 Nov 2005)
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Protein

Vacuolar protein-sorting-associated protein 37 homolog 2

Gene

VPS37-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein-sorting-associated protein 37 homolog 2
Short name:
AtVPS37-2
Alternative name(s):
ESCRT-I complex subunit VPS37 homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VPS37-2
Ordered Locus Names:At2g36680
ORF Names:F13K3.8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G36680

The Arabidopsis Information Resource

More...
TAIRi
locus:2040560, AT2G36680

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003681901 – 218Vacuolar protein-sorting-associated protein 37 homolog 2Add BLAST218

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3EBL9

PRoteomics IDEntifications database

More...
PRIDEi
Q3EBL9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
242734 [Q3EBL9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3EBL9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3EBL9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3EBL9, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the endosomal sorting required for transport complex I (ESCRT-I), composed of ELC, VPS28 and VPS37.

Interacts with ELC.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
3584, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q3EBL9, 5 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT2G36680.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3EBL9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini137 – 218VPS37 C-terminalPROSITE-ProRule annotationAdd BLAST82

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS37 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3270, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_036442_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3EBL9

KEGG Orthology (KO)

More...
KOi
K12185

Identification of Orthologs from Complete Genome Data

More...
OMAi
SPQQPWY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3EBL9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.660, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037202, ESCRT_assembly_dom
IPR029012, Helix_hairpin_bin_sf
IPR009851, Mod_r
IPR037859, Vps37

The PANTHER Classification System

More...
PANTHERi
PTHR13678, PTHR13678, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07200, Mod_r, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140111, SSF140111, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51314, VPS37_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3EBL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFNFWGSKEQ QQGQSRPSPE ASATPWYSPS LVTSPSSSRP QTSGQIPSHV
60 70 80 90 100
SPGEAAGIIA ILKDKSVDEL RKLLSDKDAY QQFLHSLDQV TIQNNIREEL
110 120 130 140 150
RKETLHLARE NLEKEPQIVE LRNQCRIIRT SELATAQEKL NELENQREEI
160 170 180 190 200
LKFYSPGSLL HRLQDAMNQV DEESEELQQK FMEKDIDTAA FVQKYKKLRS
210
KYHRRALIHL AAKTSSIG
Length:218
Mass (Da):24,987
Last modified:November 8, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27EADEA09A48DB19
GO
Isoform 2 (identifier: Q3EBL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-139: CRIIRTSELATAQEK → NNPYIRACDCSREAQ
     140-218: Missing.

Note: May be due to a competing acceptor splice site.Curated
Show »
Length:139
Mass (Da):15,718
Checksum:iD32CCA4AFBFA8F4A
GO
Isoform 3 (identifier: Q3EBL9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-168: CRIIRTSELA...LLHRLQDAMN → VNNIIQSLSE...RACDCSREAQ
     169-218: Missing.

Show »
Length:168
Mass (Da):19,067
Checksum:iB186A719F0914D3A
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD20144 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BX821771 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036799125 – 168CRIIR…QDAMN → VNNIIQSLSELIKYMKLLSI CIIFLKTVQNNPYIRACDCS REAQ in isoform 3. CuratedAdd BLAST44
Alternative sequenceiVSP_036800125 – 139CRIIR…TAQEK → NNPYIRACDCSREAQ in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_036801140 – 218Missing in isoform 2. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_036802169 – 218Missing in isoform 3. CuratedAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC006282 Genomic DNA Translation: AAD20144.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC09282.1
CP002685 Genomic DNA Translation: AEC09283.1
CP002685 Genomic DNA Translation: AEC09284.1
CP002685 Genomic DNA Translation: AEC09285.1
AY070474 mRNA Translation: AAL49940.1
AY091674 mRNA Translation: AAM10273.1
BX821771 mRNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
D84783

NCBI Reference Sequences

More...
RefSeqi
NP_001031495.1, NM_001036418.2 [Q3EBL9-3]
NP_001078013.1, NM_001084544.2 [Q3EBL9-3]
NP_850268.2, NM_179937.4 [Q3EBL9-1]
NP_850269.2, NM_179938.2 [Q3EBL9-2]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G36680.1; AT2G36680.1; AT2G36680 [Q3EBL9-1]
AT2G36680.2; AT2G36680.2; AT2G36680 [Q3EBL9-2]
AT2G36680.3; AT2G36680.3; AT2G36680 [Q3EBL9-3]
AT2G36680.4; AT2G36680.4; AT2G36680 [Q3EBL9-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
818240

Gramene; a comparative resource for plants

More...
Gramenei
AT2G36680.1; AT2G36680.1; AT2G36680 [Q3EBL9-1]
AT2G36680.2; AT2G36680.2; AT2G36680 [Q3EBL9-2]
AT2G36680.3; AT2G36680.3; AT2G36680 [Q3EBL9-3]
AT2G36680.4; AT2G36680.4; AT2G36680 [Q3EBL9-3]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G36680

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006282 Genomic DNA Translation: AAD20144.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC09282.1
CP002685 Genomic DNA Translation: AEC09283.1
CP002685 Genomic DNA Translation: AEC09284.1
CP002685 Genomic DNA Translation: AEC09285.1
AY070474 mRNA Translation: AAL49940.1
AY091674 mRNA Translation: AAM10273.1
BX821771 mRNA No translation available.
PIRiD84783
RefSeqiNP_001031495.1, NM_001036418.2 [Q3EBL9-3]
NP_001078013.1, NM_001084544.2 [Q3EBL9-3]
NP_850268.2, NM_179937.4 [Q3EBL9-1]
NP_850269.2, NM_179938.2 [Q3EBL9-2]

3D structure databases

SMRiQ3EBL9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi3584, 3 interactors
IntActiQ3EBL9, 5 interactors
STRINGi3702.AT2G36680.1

PTM databases

iPTMnetiQ3EBL9

Proteomic databases

PaxDbiQ3EBL9
PRIDEiQ3EBL9
ProteomicsDBi242734 [Q3EBL9-1]

Genome annotation databases

EnsemblPlantsiAT2G36680.1; AT2G36680.1; AT2G36680 [Q3EBL9-1]
AT2G36680.2; AT2G36680.2; AT2G36680 [Q3EBL9-2]
AT2G36680.3; AT2G36680.3; AT2G36680 [Q3EBL9-3]
AT2G36680.4; AT2G36680.4; AT2G36680 [Q3EBL9-3]
GeneIDi818240
GrameneiAT2G36680.1; AT2G36680.1; AT2G36680 [Q3EBL9-1]
AT2G36680.2; AT2G36680.2; AT2G36680 [Q3EBL9-2]
AT2G36680.3; AT2G36680.3; AT2G36680 [Q3EBL9-3]
AT2G36680.4; AT2G36680.4; AT2G36680 [Q3EBL9-3]
KEGGiath:AT2G36680

Organism-specific databases

AraportiAT2G36680
TAIRilocus:2040560, AT2G36680

Phylogenomic databases

eggNOGiKOG3270, Eukaryota
HOGENOMiCLU_036442_0_0_1
InParanoidiQ3EBL9
KOiK12185
OMAiSPQQPWY
PhylomeDBiQ3EBL9

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q3EBL9

Gene expression databases

ExpressionAtlasiQ3EBL9, baseline and differential
GenevisibleiQ3EBL9, AT

Family and domain databases

Gene3Di1.10.287.660, 1 hit
InterProiView protein in InterPro
IPR037202, ESCRT_assembly_dom
IPR029012, Helix_hairpin_bin_sf
IPR009851, Mod_r
IPR037859, Vps37
PANTHERiPTHR13678, PTHR13678, 1 hit
PfamiView protein in Pfam
PF07200, Mod_r, 1 hit
SUPFAMiSSF140111, SSF140111, 1 hit
PROSITEiView protein in PROSITE
PS51314, VPS37_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVP372_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3EBL9
Secondary accession number(s): Q8VYK5, Q9ZQA6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 8, 2005
Last modified: August 12, 2020
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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