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UniProtKB - Q3EAI1 (BH060_ARATH)
Protein
Transcription factor bHLH60
Gene
BHLH60
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: TAIR
- DNA-binding transcription factor activity Source: TAIR
- protein dimerization activity Source: InterPro
GO - Biological processi
- regulation of transcription, DNA-templated Source: TAIR
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor bHLH60Alternative name(s): Basic helix-loop-helix protein 60 Short name: AtbHLH60 Short name: bHLH 60 Transcription factor EN 91 bHLH transcription factor bHLH060 |
Gene namesi | Name:BHLH60 Synonyms:EN91 Ordered Locus Names:At3g57800 ORF Names:F15B8.10, T10K17.10 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G57800 |
TAIRi | locus:2076581, AT3G57800 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000358755 | 1 – 426 | Transcription factor bHLH60Add BLAST | 426 |
Proteomic databases
PaxDbi | Q3EAI1 |
ProteomicsDBi | 240875 [Q3EAI1-1] |
Expressioni
Tissue specificityi
Expressed constitutively in roots, leaves, stems, and flowers.1 Publication
Gene expression databases
ExpressionAtlasi | Q3EAI1, baseline and differential |
Genevisiblei | Q3EAI1, AT |
Interactioni
Subunit structurei
Homodimer.
CuratedBinary interactionsi
Isoform 2 [Q3EAI1-2]
With | #Exp. | IntAct |
---|---|---|
BHLH79 [Q9LV17] | 3 | EBI-15194889,EBI-15191993 |
IBL1 [Q9M0B9] | 3 | EBI-15194889,EBI-15192969 |
LOB [Q9FML4] | 3 | EBI-15194889,EBI-15194891 |
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 10844, 20 interactors |
IntActi | Q3EAI1, 20 interactors |
STRINGi | 3702.AT3G57800.1 |
Structurei
3D structure databases
AlphaFoldDBi | Q3EAI1 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 210 – 307 | bHLHPROSITE-ProRule annotationAdd BLAST | 98 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 117 – 201 | DisorderedSequence analysisAdd BLAST | 85 | |
Regioni | 367 – 398 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 117 – 141 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 148 – 172 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 173 – 201 | Basic and acidic residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 367 – 382 | Polar residuesSequence analysisAdd BLAST | 16 |
Phylogenomic databases
eggNOGi | ENOG502QS36, Eukaryota |
InParanoidi | Q3EAI1 |
OMAi | QYQQQWH |
PhylomeDBi | Q3EAI1 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR024097, bHLH_ZIP_TF IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR12565, PTHR12565, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q3EAI1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDLTGGFGAR SGGVGPCREP IGLESLHLGD EFRQLVTTLP PENPGGSFTA
60 70 80 90 100
LLELPPTQAV ELLHFTDSSS SQQAAVTGIG GEIPPPLHSF GGTLAFPSNS
110 120 130 140 150
VLMERAARFS VIATEQQNGN ISGETPTSSV PSNSSANLDR VKTEPAETDS
160 170 180 190 200
SQRLISDSAI ENQIPCPNQN NRNGKRKDFE KKGKSSTKKN KSSEENEKLP
210 220 230 240 250
YVHVRARRGQ ATDSHSLAER ARREKINARM KLLQELVPGC DKGTDFGGKI
260 270 280 290 300
KIKVCFGVHL LMISGKKVAI FLWKVSCEDL IDCSFSPPRI QGTALVLDEI
310 320 330 340 350
INHVQSLQRQ VEMLSMRLAA VNPRIDFNLD TILASENGSL MDGSFNAAPM
360 370 380 390 400
QLAWPQQAIE TEQSFHHRQL QQPPTQQWPF DGLNQPVWGR EEDQAHGNDN
410 420
SNLMAVSENV MVASANLHPN QVKMEL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 368 | R → Q in AAM67309 (Ref. 5) Curated | 1 | |
Sequence conflicti | 392 | E → K in AAM67309 (Ref. 5) Curated | 1 | |
Sequence conflicti | 405 | A → T in AAM10949 (PubMed:12679534).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036088 | 243 – 289 | Missing in isoform 2. 2 PublicationsAdd BLAST | 47 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF488593 mRNA Translation: AAM10949.1 AL049660 Genomic DNA Translation: CAB41175.1 AL132977 Genomic DNA Translation: CAB67608.1 CP002686 Genomic DNA Translation: AEE79702.1 CP002686 Genomic DNA Translation: AEE79703.1 AY139773 mRNA Translation: AAM98091.1 BT003037 mRNA Translation: AAO23602.1 AY085849 mRNA Translation: AAM67309.1 |
PIRi | T46002 |
RefSeqi | NP_567057.2, NM_115642.2 [Q3EAI1-1] NP_850745.1, NM_180414.3 [Q3EAI1-2] |
Genome annotation databases
EnsemblPlantsi | AT3G57800.1; AT3G57800.1; AT3G57800 [Q3EAI1-1] AT3G57800.2; AT3G57800.2; AT3G57800 [Q3EAI1-2] |
GeneIDi | 825530 |
Gramenei | AT3G57800.1; AT3G57800.1; AT3G57800 [Q3EAI1-1] AT3G57800.2; AT3G57800.2; AT3G57800 [Q3EAI1-2] |
KEGGi | ath:AT3G57800 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF488593 mRNA Translation: AAM10949.1 AL049660 Genomic DNA Translation: CAB41175.1 AL132977 Genomic DNA Translation: CAB67608.1 CP002686 Genomic DNA Translation: AEE79702.1 CP002686 Genomic DNA Translation: AEE79703.1 AY139773 mRNA Translation: AAM98091.1 BT003037 mRNA Translation: AAO23602.1 AY085849 mRNA Translation: AAM67309.1 |
PIRi | T46002 |
RefSeqi | NP_567057.2, NM_115642.2 [Q3EAI1-1] NP_850745.1, NM_180414.3 [Q3EAI1-2] |
3D structure databases
AlphaFoldDBi | Q3EAI1 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 10844, 20 interactors |
IntActi | Q3EAI1, 20 interactors |
STRINGi | 3702.AT3G57800.1 |
Proteomic databases
PaxDbi | Q3EAI1 |
ProteomicsDBi | 240875 [Q3EAI1-1] |
Genome annotation databases
EnsemblPlantsi | AT3G57800.1; AT3G57800.1; AT3G57800 [Q3EAI1-1] AT3G57800.2; AT3G57800.2; AT3G57800 [Q3EAI1-2] |
GeneIDi | 825530 |
Gramenei | AT3G57800.1; AT3G57800.1; AT3G57800 [Q3EAI1-1] AT3G57800.2; AT3G57800.2; AT3G57800 [Q3EAI1-2] |
KEGGi | ath:AT3G57800 |
Organism-specific databases
Araporti | AT3G57800 |
TAIRi | locus:2076581, AT3G57800 |
Phylogenomic databases
eggNOGi | ENOG502QS36, Eukaryota |
InParanoidi | Q3EAI1 |
OMAi | QYQQQWH |
PhylomeDBi | Q3EAI1 |
Miscellaneous databases
PROi | PR:Q3EAI1 |
Gene expression databases
ExpressionAtlasi | Q3EAI1, baseline and differential |
Genevisiblei | Q3EAI1, AT |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR024097, bHLH_ZIP_TF IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR12565, PTHR12565, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BH060_ARATH | |
Accessioni | Q3EAI1Primary (citable) accession number: Q3EAI1 Secondary accession number(s): Q8LDR2 Q9SVZ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 16, 2008 |
Last sequence update: | November 8, 2005 | |
Last modified: | May 25, 2022 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names