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UniProtKB - Q3C1V8 (BSH_HUMAN)
Protein
Brain-specific homeobox protein homolog
Gene
BSX
Organism
Homo sapiens (Human)
Status
Functioni
DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 110 – 169 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- eating behavior Source: Ensembl
- locomotory behavior Source: Ensembl
- mammary gland involution Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q3C1V8 |
SignaLinki | Q3C1V8 |
Names & Taxonomyi
Protein namesi | Recommended name: Brain-specific homeobox protein homolog |
Gene namesi | Name:BSX Synonyms:BSX1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20450, BSX |
MIMi | 611074, gene |
neXtProti | NX_Q3C1V8 |
VEuPathDBi | HostDB:ENSG00000188909 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- chromatin Source: NTNU_SB
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 390259 |
OpenTargetsi | ENSG00000188909 |
PharmGKBi | PA162377618 |
Miscellaneous databases
Pharosi | Q3C1V8, Tbio |
Genetic variation databases
BioMutai | BSX |
DMDMi | 156630463 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299170 | 1 – 233 | Brain-specific homeobox protein homologAdd BLAST | 233 |
Proteomic databases
jPOSTi | Q3C1V8 |
MassIVEi | Q3C1V8 |
PaxDbi | Q3C1V8 |
PeptideAtlasi | Q3C1V8 |
PRIDEi | Q3C1V8 |
ProteomicsDBi | 61684 |
PTM databases
iPTMneti | Q3C1V8 |
PhosphoSitePlusi | Q3C1V8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188909, Expressed in hypothalamus and 3 other tissues |
Organism-specific databases
HPAi | ENSG00000188909, Tissue enriched (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 133475, 1 interactor |
IntActi | Q3C1V8, 1 interactor |
STRINGi | 9606.ENSP00000344285 |
Miscellaneous databases
RNActi | Q3C1V8, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 160 – 233 | DisorderedSequence analysisAdd BLAST | 74 |
Sequence similaritiesi
Belongs to the distal-less homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0491, Eukaryota |
GeneTreei | ENSGT00940000161473 |
HOGENOMi | CLU_104234_0_0_1 |
InParanoidi | Q3C1V8 |
OMAi | DLPGKHC |
OrthoDBi | 1572711at2759 |
PhylomeDBi | Q3C1V8 |
TreeFami | TF350735 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3C1V8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLNFTSPLH PASSQRPTSF FIEDILLHKP KPLREVAPDH FASSLASRVP
60 70 80 90 100
LLDYGYPLMP TPTLLAPHAH HPLHKGDHHH PYFLTTSGMP VPALFPHPQH
110 120 130 140 150
AELPGKHCRR RKARTVFSDS QLSGLEKRFE IQRYLSTPER VELATALSLS
160 170 180 190 200
ETQVKTWFQN RRMKHKKQLR KSQDEPKAPD GPESPEGSPR GSEAATAAEA
210 220 230
RLSLPAGPFV LTEPEDEVDI GDEGELGSGP HVL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | G → S in BAE46889 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP003040 Genomic DNA No translation available. AB231738 mRNA Translation: BAE46889.1 |
CCDSi | CCDS41728.1 |
RefSeqi | NP_001091639.1, NM_001098169.1 |
Genome annotation databases
Ensembli | ENST00000343035.3; ENSP00000344285.2; ENSG00000188909.5 |
GeneIDi | 390259 |
KEGGi | hsa:390259 |
MANE-Selecti | ENST00000343035.3; ENSP00000344285.2; NM_001098169.2; NP_001091639.1 |
UCSCi | uc010rzs.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight Of fidgets and food - Issue 85 of August 2007 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP003040 Genomic DNA No translation available. AB231738 mRNA Translation: BAE46889.1 |
CCDSi | CCDS41728.1 |
RefSeqi | NP_001091639.1, NM_001098169.1 |
3D structure databases
AlphaFoldDBi | Q3C1V8 |
SMRi | Q3C1V8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 133475, 1 interactor |
IntActi | Q3C1V8, 1 interactor |
STRINGi | 9606.ENSP00000344285 |
PTM databases
iPTMneti | Q3C1V8 |
PhosphoSitePlusi | Q3C1V8 |
Genetic variation databases
BioMutai | BSX |
DMDMi | 156630463 |
Proteomic databases
jPOSTi | Q3C1V8 |
MassIVEi | Q3C1V8 |
PaxDbi | Q3C1V8 |
PeptideAtlasi | Q3C1V8 |
PRIDEi | Q3C1V8 |
ProteomicsDBi | 61684 |
Protocols and materials databases
Antibodypediai | 9208, 104 antibodies from 19 providers |
DNASUi | 390259 |
Genome annotation databases
Ensembli | ENST00000343035.3; ENSP00000344285.2; ENSG00000188909.5 |
GeneIDi | 390259 |
KEGGi | hsa:390259 |
MANE-Selecti | ENST00000343035.3; ENSP00000344285.2; NM_001098169.2; NP_001091639.1 |
UCSCi | uc010rzs.3, human |
Organism-specific databases
CTDi | 390259 |
DisGeNETi | 390259 |
GeneCardsi | BSX |
HGNCi | HGNC:20450, BSX |
HPAi | ENSG00000188909, Tissue enriched (brain) |
MIMi | 611074, gene |
neXtProti | NX_Q3C1V8 |
OpenTargetsi | ENSG00000188909 |
PharmGKBi | PA162377618 |
VEuPathDBi | HostDB:ENSG00000188909 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0491, Eukaryota |
GeneTreei | ENSGT00940000161473 |
HOGENOMi | CLU_104234_0_0_1 |
InParanoidi | Q3C1V8 |
OMAi | DLPGKHC |
OrthoDBi | 1572711at2759 |
PhylomeDBi | Q3C1V8 |
TreeFami | TF350735 |
Enzyme and pathway databases
PathwayCommonsi | Q3C1V8 |
SignaLinki | Q3C1V8 |
Miscellaneous databases
BioGRID-ORCSi | 390259, 11 hits in 1090 CRISPR screens |
ChiTaRSi | BSX, human |
GenomeRNAii | 390259 |
Pharosi | Q3C1V8, Tbio |
PROi | PR:Q3C1V8 |
RNActi | Q3C1V8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188909, Expressed in hypothalamus and 3 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BSH_HUMAN | |
Accessioni | Q3C1V8Primary (citable) accession number: Q3C1V8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | August 21, 2007 | |
Last modified: | May 25, 2022 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries