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Protein

Disintegrin ocellatusin

Gene
N/A
Organism
Echis ocellatus (Ocellated saw-scaled viper)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The disintegrin ocellatusin-10c1 is a poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of cells expressing the RGD-dependent integrin alpha-5/beta-1 (ITGA5/ITGB1) to immobilized fibronectin. Inhibition on alpha-2b/beta-3 (ITGA2B/ITGB3) is low, and there is no inhibition on alpha-1/beta-1 (ITGA1/ITGB1), alpha-2/beta-1 (ITGA2/ITGB1) and alpha-6/beta-1 (ITGA6/ITGB1) (By similarity).By similarity
The short monomeric disintegrin ocellatusin inhibits ADP-induced platelet aggregation (IC50=168 nM). Inhibits alpha-5/beta-1 (ITGA5/ITGB1) integrin and induces the expression of a ligand-induced binding site epitope on beta-1 integrin subunit. Has a direct chemotactic stimulus on human neutrophils in vitro.1 Publication

Caution

The disintegrin is also encoded by another precursor (AC Q14FJ4).Curated

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin ocellatusin
Alternative name(s):
Short ocellatusion precursor Eo10c-10
OrganismiEchis ocellatus (Ocellated saw-scaled viper)
Taxonomic identifieri99586 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeEchis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000031904221 – 651 PublicationAdd BLAST45
ChainiPRO_500007691266 – 115Disintegrin ocellatusinAdd BLAST50
PropeptideiPRO_0000319043116 – 128Add BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 59PROSITE-ProRule annotation
Disulfide bondi67 ↔ 76PROSITE-ProRule annotation
Disulfide bondi72 ↔ 97PROSITE-ProRule annotation
Disulfide bondi73 ↔ 102PROSITE-ProRule annotation
Disulfide bondi85 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ3BER1
SMRiQ3BER1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 112DisintegrinPROSITE-ProRule annotationAdd BLAST87

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi89 – 91Cell attachment site3

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG051359

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3BER1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPVLLVTIC LAVFPFQGSS IILESGNIND YEIVYPKKVA VLPTGAMNSA
60 70 80 90 100
HPCYDPVTCQ PKEKEDCESG PCCDNCKFLK EGTICKMARG DNMHDYCNGK
110 120
TCDCPRNPYK GEHDPMEWPA PAKGSVLM
Length:128
Mass (Da):14,076
Last modified:November 22, 2005 - v1
Checksum:i0BE6AB6E856A0C68
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115P → T AA sequence (PubMed:11852062).Curated1

Mass spectrometryi

Molecular mass is 5598±2 Da from positions 66 - 115. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM117392 mRNA Translation: CAJ40969.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM117392 mRNA Translation: CAJ40969.1

3D structure databases

ProteinModelPortaliQ3BER1
SMRiQ3BER1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG051359

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDIS_ECHOC
AccessioniPrimary (citable) accession number: Q3BER1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 22, 2005
Last modified: November 22, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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