UniProtKB - Q3BER1 (DIS_ECHOC)
Disintegrin ocellatusin
Functioni
The disintegrin ocellatusin-10c1 is a poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of cells expressing the RGD-dependent integrin alpha-5/beta-1 (ITGA5/ITGB1) to immobilized fibronectin. Inhibition on alpha-2b/beta-3 (ITGA2B/ITGB3) is low, and there is no inhibition on alpha-1/beta-1 (ITGA1/ITGB1), alpha-2/beta-1 (ITGA2/ITGB1) and alpha-6/beta-1 (ITGA6/ITGB1) (By similarity).
By similarityThe short monomeric disintegrin ocellatusin inhibits ADP-induced platelet aggregation (IC50=168 nM). Inhibits alpha-5/beta-1 (ITGA5/ITGB1) integrin and induces the expression of a ligand-induced binding site epitope on beta-1 integrin subunit. Has a direct chemotactic stimulus on human neutrophils in vitro.
1 PublicationCaution
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Cell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Disintegrin ocellatusin2 PublicationsAlternative name(s): Short ocellatusion precursor Eo10c-101 Publication |
Organismi | Echis ocellatus (Ocellated saw-scaled viper) |
Taxonomic identifieri | 99586 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Viperinae › Echis |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
PropeptideiPRO_0000319042 | 21 – 65 | 1 PublicationAdd BLAST | 45 | |
ChainiPRO_5000076912 | 66 – 115 | Disintegrin ocellatusinAdd BLAST | 50 | |
PropeptideiPRO_0000319043 | 116 – 128 | Add BLAST | 13 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 53 ↔ 59 | PROSITE-ProRule annotation | ||
Disulfide bondi | 67 ↔ 76 | PROSITE-ProRule annotation | ||
Disulfide bondi | 72 ↔ 97 | PROSITE-ProRule annotation | ||
Disulfide bondi | 73 ↔ 102 | PROSITE-ProRule annotation | ||
Disulfide bondi | 85 ↔ 104 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Interactioni
Subunit structurei
Monomer.
1 PublicationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 112 | DisintegrinPROSITE-ProRule annotationAdd BLAST | 87 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 89 – 91 | Cell attachment site | 3 |
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf |
Pfami | View protein in Pfam PF00200, Disintegrin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MIPVLLVTIC LAVFPFQGSS IILESGNIND YEIVYPKKVA VLPTGAMNSA
60 70 80 90 100
HPCYDPVTCQ PKEKEDCESG PCCDNCKFLK EGTICKMARG DNMHDYCNGK
110 120
TCDCPRNPYK GEHDPMEWPA PAKGSVLM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 115 | P → T AA sequence (PubMed:11852062).Curated | 1 |
Mass spectrometryi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM117392 mRNA Translation: CAJ40969.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM117392 mRNA Translation: CAJ40969.1 |
3D structure databases
SMRi | Q3BER1 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf |
Pfami | View protein in Pfam PF00200, Disintegrin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DIS_ECHOC | |
Accessioni | Q3BER1Primary (citable) accession number: Q3BER1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | November 22, 2005 | |
Last modified: | December 2, 2020 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families