Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 101 (11 Dec 2019)
Sequence version 2 (28 Mar 2018)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Neuroblastoma breakpoint family member 1

Gene

NBPF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuroblastoma breakpoint family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NBPF1
Synonyms:KIAA1693
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000219481.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26088 NBPF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610501 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3BBV0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55672

Open Targets

More...
OpenTargetsi
ENSG00000219481

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128395786

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q3BBV0 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NBPF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121942439

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002880371 – 1214Neuroblastoma breakpoint family member 1Add BLAST1214

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3BBV0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3BBV0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q3BBV0

PeptideAtlas

More...
PeptideAtlasi
Q3BBV0

PRoteomics IDEntifications database

More...
PRIDEi
Q3BBV0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61674

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3BBV0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3BBV0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. The only tissue which shows a weak expression is kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000219481 Expressed in 162 organ(s), highest expression level in C1 segment of cervical spinal cord

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3BBV0 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038748
HPA042595
HPA043105
HPA043692
HPA044023
HPA046971
HPA058050

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120804, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q3BBV0, 5 interactors

Molecular INTeraction database

More...
MINTi
Q3BBV0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000474456

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3BBV0 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini165 – 259NBPF 1PROSITE-ProRule annotationAdd BLAST95
Domaini436 – 530NBPF 2PROSITE-ProRule annotationAdd BLAST95
Domaini707 – 799NBPF 3PROSITE-ProRule annotationAdd BLAST93
Domaini800 – 888NBPF 4PROSITE-ProRule annotationAdd BLAST89
Domaini891 – 946NBPF 5PROSITE-ProRule annotationAdd BLAST56
Domaini947 – 1038NBPF 6PROSITE-ProRule annotationAdd BLAST92
Domaini1041 – 1114NBPF 7PROSITE-ProRule annotationAdd BLAST74
Domaini1116 – 1214NBPF 8PROSITE-ProRule annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili70 – 128Sequence analysisAdd BLAST59
Coiled coili292 – 399Sequence analysisAdd BLAST108
Coiled coili610 – 670Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi806 – 810Poly-Glu5
Compositional biasi821 – 826Poly-Glu6
Compositional biasi1028 – 1031Poly-Glu4
Compositional biasi1116 – 1121Poly-Arg6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NBPF family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00420000029746

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3BBV0

Identification of Orthologs from Complete Genome Data

More...
OMAi
PSEKSEM

Database of Orthologous Groups

More...
OrthoDBi
372685at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3BBV0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010630 Olduvai_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06758 Olduvai, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01148 DUF1220, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51316 NBPF, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3BBV0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVVSAGPWSS EKAETNILEI NEKLRPQLAE NKQQFRNLKE KCFVTQLAGF
60 70 80 90 100
LANRQKKYKY EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH
110 120 130 140 150
SQERELTQLR EKLREGRDAS RSLNQHLQAL LTPDKPDKSQ GQDLQEQLAE
160 170 180 190 200
GCRLAQQLFQ KLSPENDEDE DEDVQVEEAE KVLESSAPRE VQKAEESKVP
210 220 230 240 250
EDSLEECAIT CSNSHSPCDS NQPHKNINIT FEEDKVNSTL VVDRESSHDE
260 270 280 290 300
CQDAVNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLHPQLA
310 320 330 340 350
EKKQQFRNLK EKCFVTQLAC FLANQQNKYK YEECKDLIKS MLRNERQFKE
360 370 380 390 400
EKLAEQLKQA EELRQYKVLV HSQERELTQL REKLREGRDA SRSLNQHLQA
410 420 430 440 450
LLTPDKPDKS QGQDLQEQLA EGCRLAQQLF QKLSPENDED EDEDVQVEEA
460 470 480 490 500
EKVLESSAPR EVQKAEESKV PEDSLEECAI TCSNSHGPCD SNQPHKNINI
510 520 530 540 550
TFEEDKVNSA LVVDRESSHD ECQDAVNILP VPGPTSSATN VSMVVSAGPL
560 570 580 590 600
SSEKAEMNIL EINEKLHPQL AEKKQQFRNL KEKCFVTQLA CFLANQQNKY
610 620 630 640 650
KNEECKDLIK SMLRNERQFK EEKLAEQLKQ AEELRQYKVL VHSQERELTQ
660 670 680 690 700
LREKLREGRD ASCSLNQHLQ ALLTPDEPDK SQGQDLQEQL AEGCRLAQHL
710 720 730 740 750
VQKLSPENDN DDDEDVQVEV AEKVQKSSAP REMPKAEEKE VPEDSLEECA
760 770 780 790 800
ITCSNSHGPY DSNQPHRKTK ITFEEDKVDS TLIGSSSHVE WEDAVHIIPE
810 820 830 840 850
NESDDEEEEE KGPVSPRNLQ ESEEEEVPQE SWDEGYSTLS IPPEMLASYK
860 870 880 890 900
SYSGTFHSLE EQQVCMAVDI GGHRWDQVKK EDQEATGPRL SRELLDEKGP
910 920 930 940 950
EVLQDSLDRC YSTPSGYLEL TDSCQPYRSA FYILEQQRVG WALDMDEIEK
960 970 980 990 1000
YQEVEEDQDP SCPRLSRELL DEKEPEVLQD SLDRCYSTPS GYLELPDLGQ
1010 1020 1030 1040 1050
PYRSAVYSLE EQYLGLALDV DRIKKDQEEE EDQGPPCPRL SRELLEAVEP
1060 1070 1080 1090 1100
EVLQDSLDRC YSTPSSCLEQ PDSCLPYGSS FYALEEKHVG FSLDVGEIEK
1110 1120 1130 1140 1150
KGKGKKRRGR RSTKKRRRRG RKEGEEDQNP PCPRLSGMLM EVEEPEVLQD
1160 1170 1180 1190 1200
SLDRCYSTPS MYFELPDSFQ HYRSVFYSFE EQHISFALDV DNRFLTLMGT
1210
SLHLVFQMGV IFPQ
Length:1,214
Mass (Da):139,258
Last modified:March 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEEE78B814EEF5BDF
GO
Isoform 2 (identifier: Q3BBV0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     962-1036: Missing.

Show »
Length:1,139
Mass (Da):130,646
Checksum:i0A875285213FAB69
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R2X0S4R2X0_HUMAN
Neuroblastoma breakpoint family mem...
NBPF1
1,096Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2Z6S4R2Z6_HUMAN
Neuroblastoma breakpoint family mem...
NBPF1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135K → E in AAX85114 (PubMed:16079250).Curated1
Sequence conflicti157 – 159QLF → HLV in AAX85114 (PubMed:16079250).Curated3
Sequence conflicti216S → G in AAX85114 (PubMed:16079250).Curated1
Sequence conflicti291I → M in AAX85114 (PubMed:16079250).Curated1
Sequence conflicti296H → R in AAX85114 (PubMed:16079250).Curated1
Sequence conflicti320C → G in AAX85114 (PubMed:16079250).Curated1
Sequence conflicti335K → E in AAX85114 (PubMed:16079250).Curated1
Sequence conflicti406K → E in AAX85114 (PubMed:16079250).Curated1
Sequence conflicti428 – 430QLF → HLV in AAX85114 (PubMed:16079250).Curated3
Sequence conflicti487G → S in BAB21784 (PubMed:11214970).Curated1
Sequence conflicti562I → M in AAX85114 (PubMed:16079250).Curated1
Sequence conflicti567H → R in AAX85114 (PubMed:16079250).Curated1
Sequence conflicti602N → Y in AAX85114 (PubMed:16079250).Curated1
Sequence conflicti699 – 701HLV → QLF in AAX85114 (PubMed:16079250).Curated3
Sequence conflicti1138M → V in BAB21784 (PubMed:11214970).Curated1
Sequence conflicti1138M → V in AAH34418 (PubMed:15489334).Curated1
Sequence conflicti1162Y → F in BAB21784 (PubMed:11214970).Curated1
Sequence conflicti1162Y → F in AAH34418 (PubMed:15489334).Curated1
Sequence conflicti1200T → R in BAB21784 (PubMed:11214970).Curated1
Sequence conflicti1200T → R in AAH34418 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03236420I → M. Corresponds to variant dbSNP:rs9730080Ensembl.1
Natural variantiVAR_03236531N → K. Corresponds to variant dbSNP:rs9730077Ensembl.1
Natural variantiVAR_032366510A → T1 PublicationCorresponds to variant dbSNP:rs681623Ensembl.1
Natural variantiVAR_032367591C → G. Corresponds to variant dbSNP:rs3738661Ensembl.1
Natural variantiVAR_032368612M → V1 PublicationCorresponds to variant dbSNP:rs672812Ensembl.1
Natural variantiVAR_032369663C → R1 PublicationCorresponds to variant dbSNP:rs28453011Ensembl.1
Natural variantiVAR_032370712D → H1 PublicationCorresponds to variant dbSNP:rs3901680Ensembl.1
Natural variantiVAR_032371726K → E. Corresponds to variant dbSNP:rs3901679Ensembl.1
Natural variantiVAR_032372734P → Q1 PublicationCorresponds to variant dbSNP:rs9727080Ensembl.1
Natural variantiVAR_032373850K → Q2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059360962 – 1036Missing in isoform 2. CuratedAdd BLAST75

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY894575 mRNA Translation: AAX85114.1
AL137798 Genomic DNA No translation available.
AL355149 Genomic DNA No translation available.
AB051480 mRNA Translation: BAB21784.1
BC034418 mRNA Translation: AAH34418.1

NCBI Reference Sequences

More...
RefSeqi
NP_060410.2, NM_017940.4 [Q3BBV0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000430580; ENSP00000474456; ENSG00000219481 [Q3BBV0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55672

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55672

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY894575 mRNA Translation: AAX85114.1
AL137798 Genomic DNA No translation available.
AL355149 Genomic DNA No translation available.
AB051480 mRNA Translation: BAB21784.1
BC034418 mRNA Translation: AAH34418.1
RefSeqiNP_060410.2, NM_017940.4 [Q3BBV0-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120804, 4 interactors
IntActiQ3BBV0, 5 interactors
MINTiQ3BBV0
STRINGi9606.ENSP00000474456

PTM databases

iPTMnetiQ3BBV0
PhosphoSitePlusiQ3BBV0

Polymorphism and mutation databases

BioMutaiNBPF1
DMDMi121942439

Proteomic databases

EPDiQ3BBV0
jPOSTiQ3BBV0
MassIVEiQ3BBV0
PeptideAtlasiQ3BBV0
PRIDEiQ3BBV0
ProteomicsDBi61674

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55672

Genome annotation databases

EnsembliENST00000430580; ENSP00000474456; ENSG00000219481 [Q3BBV0-2]
GeneIDi55672
KEGGihsa:55672

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55672
DisGeNETi55672
EuPathDBiHostDB:ENSG00000219481.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NBPF1
HGNCiHGNC:26088 NBPF1
HPAiHPA038748
HPA042595
HPA043105
HPA043692
HPA044023
HPA046971
HPA058050
MIMi610501 gene
neXtProtiNX_Q3BBV0
OpenTargetsiENSG00000219481
PharmGKBiPA128395786

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00420000029746
InParanoidiQ3BBV0
OMAiPSEKSEM
OrthoDBi372685at2759
PhylomeDBiQ3BBV0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NBPF1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55672
PharosiQ3BBV0 Tdark

Protein Ontology

More...
PROi
PR:Q3BBV0
RNActiQ3BBV0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000219481 Expressed in 162 organ(s), highest expression level in C1 segment of cervical spinal cord
ExpressionAtlasiQ3BBV0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR010630 Olduvai_dom
PfamiView protein in Pfam
PF06758 Olduvai, 8 hits
SMARTiView protein in SMART
SM01148 DUF1220, 8 hits
PROSITEiView protein in PROSITE
PS51316 NBPF, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNBPF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3BBV0
Secondary accession number(s): Q8N4E8, Q9C0H0, S4R3K2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 28, 2018
Last modified: December 11, 2019
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again