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Protein

TSC22 domain family protein 4

Gene

Tsc22d4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TSC22 domain family protein 4
Alternative name(s):
TSC22-related-inducible leucine zipper protein 2
Thg-1pit
Gene namesi
Name:Tsc22d4
Synonyms:Tilz2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1584380 Tsc22d4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004176691 – 387TSC22 domain family protein 4Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57PhosphothreonineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei165PhosphoserineCombined sources1
Modified residuei183PhosphothreonineBy similarity1
Modified residuei187PhosphoserineBy similarity1
Modified residuei189PhosphoserineBy similarity1
Modified residuei223PhosphothreonineCombined sources1
Modified residuei254PhosphoserineBy similarity1
Modified residuei258PhosphoserineBy similarity1
Modified residuei271PhosphoserineCombined sources1
Modified residuei362PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3B8N7
PRIDEiQ3B8N7

PTM databases

iPTMnetiQ3B8N7
PhosphoSitePlusiQ3B8N7

Expressioni

Gene expression databases

BgeeiENSRNOG00000024616 Expressed in 9 organ(s), highest expression level in heart
ExpressionAtlasiQ3B8N7 baseline and differential
GenevisibleiQ3B8N7 RN

Interactioni

Subunit structurei

Forms a homodimer or heterodimer. Can form a heterodimer with TSC22D1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056350

Structurei

3D structure databases

ProteinModelPortaliQ3B8N7
SMRiQ3B8N7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni336 – 357Leucine-zipperAdd BLAST22

Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGiKOG4797 Eukaryota
ENOG411251N LUCA
GeneTreeiENSGT00530000063062
HOGENOMiHOG000253006
HOVERGENiHBG069048
InParanoidiQ3B8N7
OMAiCVDIYER
OrthoDBiEOG091G06PM
PhylomeDBiQ3B8N7

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PANTHERiPTHR12348 PTHR12348, 1 hit
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007152 TSC-22_Dip_Bun, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q3B8N7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGGKKKSSF QITSVTTDYE GPGSPGASDP PAPPAPAGPP PRLPNGEPNP
60 70 80 90 100
DPGGRGTPRN GSPPPGAPAS RFRVVKLPQG LGEPYRRGRW TCVDVYERDL
110 120 130 140 150
EPPSFGRLLE GIRGASGGTG GRSLDSRLEL ASLGISTPIP QPGLSQGPTS
160 170 180 190 200
WLRPPPTSPG PQARSFTGGL GQLAGPGKAK VETPPLSASP PQQRPPGPGT
210 220 230 240 250
GDSAQTLPSL RVEVESGGLA AGTPPLSRRR DGAVRLRMEL VAPEETGKVP
260 270 280 290 300
PIDSRPNSPA LYFDASLVHK SPDPFGAAAA QSLSLARSML AISGHLDSDD
310 320 330 340 350
DSGSGSLVGI DNKIEQAMDL VKSHLMFAVR EEVEVLKEQI RDLAERNAAL
360 370 380
EQENGLLRAL ASPEQLAQLP SSGLPRLGPS APNGPSI
Length:387
Mass (Da):40,041
Last modified:November 22, 2005 - v1
Checksum:i20B00F4ACFB8F739
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6AY52CG061_RAT
Uncharacterized protein C7orf61 hom...
200Annotation score:
A0A0G2K1V1A0A0G2K1V1_RAT
TSC22 domain family protein 4
LOC102550456 LOC100362783, Tsc22d4
586Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473973 Genomic DNA Translation: EDM13242.1
BC105911 mRNA Translation: AAI05912.1
RefSeqiNP_001037749.1, NM_001044284.3
XP_006249139.1, XM_006249077.3
XP_017459950.1, XM_017604461.1
UniGeneiRn.21359
Rn.224681
Rn.224768

Genome annotation databases

EnsembliENSRNOT00000039280; ENSRNOP00000033658; ENSRNOG00000050805
ENSRNOT00000059592; ENSRNOP00000056350; ENSRNOG00000024616
GeneIDi102550456
684980
KEGGirno:102550456
rno:684980

Similar proteinsi

Entry informationi

Entry nameiT22D4_RAT
AccessioniPrimary (citable) accession number: Q3B8N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: November 22, 2005
Last modified: September 12, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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