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Entry version 120 (12 Aug 2020)
Sequence version 3 (18 May 2010)
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Protein

Prospero homeobox protein 2

Gene

PROX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q3B8N5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prospero homeobox protein 2
Alternative name(s):
Homeobox prospero-like protein PROX2
Short name:
PROX-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PROX2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000119608.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26715, PROX2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615094, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3B8N5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
283571

Open Targets

More...
OpenTargetsi
ENSG00000119608

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162400142

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q3B8N5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PROX2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452993

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003426771 – 592Prospero homeobox protein 2Add BLAST592

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q3B8N5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3B8N5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3B8N5

PeptideAtlas

More...
PeptideAtlasi
Q3B8N5

PRoteomics IDEntifications database

More...
PRIDEi
Q3B8N5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61672 [Q3B8N5-1]
61673 [Q3B8N5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3B8N5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3B8N5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119608, Expressed in stromal cell of endometrium and 98 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3B8N5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3B8N5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000119608, Tissue enhanced (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000451223

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3B8N5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3B8N5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini437 – 495Prospero-type homeoPROSITE-ProRule annotationAdd BLAST59
Domaini496 – 592ProsperoPROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni437 – 592Homeo-ProsperoPROSITE-ProRule annotationAdd BLAST156

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.PROSITE-ProRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Prospero homeodomain family.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3779, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154790

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_064097_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3B8N5

KEGG Orthology (KO)

More...
KOi
K20212

Database of Orthologous Groups

More...
OrthoDBi
373478at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3B8N5

TreeFam database of animal gene trees

More...
TreeFami
TF316638

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.500, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023082, Homeo_prospero_dom
IPR037131, Homeo_prospero_dom_sf
IPR009057, Homeobox-like_sf
IPR039350, Prospero_homeodomain

The PANTHER Classification System

More...
PANTHERi
PTHR12198, PTHR12198, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05044, HPD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51818, HOMEO_PROSPERO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3B8N5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPNSILLSP QPQICSHLAE ACTEGERSSS PPELDRDSPF PWSQVPSSSP
60 70 80 90 100
TDPEWFGDEH IQAKRARVET IVRGMCLSPN PLVPGNAQAG VSPRCPKKAR
110 120 130 140 150
ERKRKQNLPT PQGLLMPAPA WDQGNRKGGP RVREQLHLLK QQLRHLQEHI
160 170 180 190 200
LQAAKPRDTA QGPGGCGTGK GPLSAKQGNG CGPRPWVVDG DHQQGTSKDL
210 220 230 240 250
SGAEKHQESE KPSFLPSGAP ASLEILRKEL TRAVSQAVDS VLQKVLLDPP
260 270 280 290 300
GHLTQLGRSF QGQVAEGRSE PSPPVGGACK DPLALAALPR RVQLQAGVPV
310 320 330 340 350
GNLSLAKRLD SPRYPIPPRM TPKPCQDPPA NFPLTAPSHI QENQILSQLL
360 370 380 390 400
GHRYNNGHWS SSPPQDSSSQ RHPSSEPALR PWRTTKPQPL VLSQQQCPLP
410 420 430 440 450
FTSAHLESLP LLPSVKMEQR GLHAVMEALP FSLLHIQEGL NPGHLKKAKL
460 470 480 490 500
MFFFTRYPSS NLLKVYFPDV QFNRCITSQM IKWFSNFREF YYIQMEKSAR
510 520 530 540 550
QAISDGVTNP KMLVVLRNSE LFQALNMHYN KGNDFEVPDC FLEIASLTLQ
560 570 580 590
EFFRAVSAGR DSDPSWKKPI YKIISKLDSD IPEIFKSSSY PQ
Length:592
Mass (Da):65,586
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F1AC21D355E743D
GO
Isoform 2 (identifier: Q3B8N5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-471: Missing.

Show »
Length:365
Mass (Da):40,573
Checksum:i96B2E5FA24D89535
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V3G0G3V3G0_HUMAN
Prospero homeobox protein 2
PROX2
592Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMC2A0A0G2JMC2_HUMAN
Prospero homeobox protein 2
PROX2
8Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04278 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti434L → V in AAI05721 (PubMed:15489334).Curated1
Sequence conflicti434L → V in AAI05928 (PubMed:15489334).Curated1
Sequence conflicti509N → D in BAC04278 (PubMed:14702039).Curated1
Sequence conflicti511K → E in BAC04278 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069378474R → H Found in a patient with mental retardation, seizures, mild hypotonia and no speech. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034528245 – 471Missing in isoform 2. 1 PublicationAdd BLAST227

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC006530 Genomic DNA No translation available.
BC105720 mRNA Translation: AAI05721.1
BC105927 mRNA Translation: AAI05928.1
AK094068 mRNA Translation: BAC04278.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45136.2 [Q3B8N5-2]
CCDS73663.1 [Q3B8N5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001073877.2, NM_001080408.2 [Q3B8N5-2]
NP_001229936.1, NM_001243007.1
XP_005267600.1, XM_005267543.3 [Q3B8N5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000556084; ENSP00000451463; ENSG00000119608 [Q3B8N5-2]
ENST00000673765; ENSP00000501015; ENSG00000119608 [Q3B8N5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
283571

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:283571

UCSC genome browser

More...
UCSCi
uc001xqq.3, human [Q3B8N5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006530 Genomic DNA No translation available.
BC105720 mRNA Translation: AAI05721.1
BC105927 mRNA Translation: AAI05928.1
AK094068 mRNA Translation: BAC04278.1 Different initiation.
CCDSiCCDS45136.2 [Q3B8N5-2]
CCDS73663.1 [Q3B8N5-1]
RefSeqiNP_001073877.2, NM_001080408.2 [Q3B8N5-2]
NP_001229936.1, NM_001243007.1
XP_005267600.1, XM_005267543.3 [Q3B8N5-1]

3D structure databases

SMRiQ3B8N5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000451223

PTM databases

iPTMnetiQ3B8N5
PhosphoSitePlusiQ3B8N5

Polymorphism and mutation databases

BioMutaiPROX2
DMDMi296452993

Proteomic databases

MassIVEiQ3B8N5
MaxQBiQ3B8N5
PaxDbiQ3B8N5
PeptideAtlasiQ3B8N5
PRIDEiQ3B8N5
ProteomicsDBi61672 [Q3B8N5-1]
61673 [Q3B8N5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
50733, 77 antibodies

Genome annotation databases

EnsembliENST00000556084; ENSP00000451463; ENSG00000119608 [Q3B8N5-2]
ENST00000673765; ENSP00000501015; ENSG00000119608 [Q3B8N5-2]
GeneIDi283571
KEGGihsa:283571
UCSCiuc001xqq.3, human [Q3B8N5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
283571
DisGeNETi283571
EuPathDBiHostDB:ENSG00000119608.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PROX2
HGNCiHGNC:26715, PROX2
HPAiENSG00000119608, Tissue enhanced (skin)
MIMi615094, gene
neXtProtiNX_Q3B8N5
OpenTargetsiENSG00000119608
PharmGKBiPA162400142

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3779, Eukaryota
GeneTreeiENSGT00940000154790
HOGENOMiCLU_064097_0_0_1
InParanoidiQ3B8N5
KOiK20212
OrthoDBi373478at2759
PhylomeDBiQ3B8N5
TreeFamiTF316638

Enzyme and pathway databases

PathwayCommonsiQ3B8N5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
283571, 4 hits in 892 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
283571
PharosiQ3B8N5, Tbio

Protein Ontology

More...
PROi
PR:Q3B8N5
RNActiQ3B8N5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119608, Expressed in stromal cell of endometrium and 98 other tissues
ExpressionAtlasiQ3B8N5, baseline and differential
GenevisibleiQ3B8N5, HS

Family and domain databases

Gene3Di1.10.10.500, 1 hit
InterProiView protein in InterPro
IPR023082, Homeo_prospero_dom
IPR037131, Homeo_prospero_dom_sf
IPR009057, Homeobox-like_sf
IPR039350, Prospero_homeodomain
PANTHERiPTHR12198, PTHR12198, 1 hit
PfamiView protein in Pfam
PF05044, HPD, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51818, HOMEO_PROSPERO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPROX2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3B8N5
Secondary accession number(s): C9J5W1, Q8N9Q3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 120 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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