Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Erythroid differentiation-related factor 1

Gene

EDRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Erythroid differentiation-related factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EDRF1
Synonyms:C10orf137
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000107938.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24640 EDRF1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3B7T1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26098

Open Targets

More...
OpenTargetsi
ENSG00000107938

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134873666

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EDRF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
109826957

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002442601 – 1238Erythroid differentiation-related factor 1Add BLAST1238

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3B7T1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3B7T1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3B7T1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3B7T1

PeptideAtlas

More...
PeptideAtlasi
Q3B7T1

PRoteomics IDEntifications database

More...
PRIDEi
Q3B7T1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61658
61659 [Q3B7T1-3]
61660 [Q3B7T1-4]
61661 [Q3B7T1-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3B7T1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3B7T1

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q3B7T1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000107938 Expressed in 221 organ(s), highest expression level in body of pancreas

CleanEx database of gene expression profiles

More...
CleanExi
HS_C10orf137

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3B7T1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3B7T1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031820

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117548, 52 interactors

Protein interaction database and analysis system

More...
IntActi
Q3B7T1, 23 interactors

Molecular INTeraction database

More...
MINTi
Q3B7T1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000349244

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q3B7T1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati693 – 726TPR 1Add BLAST34
Repeati914 – 953TPR 2Add BLAST40

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF2A Eukaryota
ENOG410XSWW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014797

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081471

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3B7T1

Identification of Orthologs from Complete Genome Data

More...
OMAi
CGAGDEF

Database of Orthologous Groups

More...
OrthoDBi
323777at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3B7T1

TreeFam database of animal gene trees

More...
TreeFami
TF324739

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3B7T1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDAKEAGAE GPPAGAAARG GLSLLSQGES EESSAQGSAL FLGGNEVKSR
60 70 80 90 100
AVVKYSSAPP RTAFARLEEK TDLKLPPANW LRESAKLGPA GTTILGNSKK
110 120 130 140 150
SKPFSSFGMA YDFIDSVGND VDVVSDSENI KKLLKIPYSK SHVSMAVHRI
160 170 180 190 200
GRTLLLDELD IQELFMRSSQ TGDWTWLKEF YQRLIDQKWQ RKKKSKEHWY
210 220 230 240 250
QKAILSKFLY YSINGDGAAQ PVSSTAEQQE SSSSDQTNDS EGASWPAPFE
260 270 280 290 300
MPSSVSEDPS ASSQGSEPLE PSYIVGHVAS APKEQNLITL FNDGEHSQGL
310 320 330 340 350
KNDFVRNILW TFEDIHMLVG SNMPIFGGGR YPAVSLRLRD NNKPINVLTG
360 370 380 390 400
IDYWLDNLIC NVPELVMCFH VNGIVQKYEM IKTEEIPNLE NSNFSTKVIK
410 420 430 440 450
DIAQNILSFL KSNCTKEGHT YWLFKASGSD IVKLYDLTTL CEETEDKYQN
460 470 480 490 500
PFTMPVAILL YKVACNMMMK KNQNKKHYGT IRTLLLNCLK LLDKSRHPQI
510 520 530 540 550
IASANYMLSE LFQLDEPKKE ENSESPLNEN SDESYSEEEE EMPDSDENGS
560 570 580 590 600
YSTSSDPSDD SKAVAIIKSV GELSVPEKYK SIHQIRPSCA FPVCHDTEER
610 620 630 640 650
CRLVLSYVLE GLKSVDSSIK KESDLPAADP STPIPLKYED ESSRGGPEGL
660 670 680 690 700
EKQMALFLDK MGSLQKGNYS SQSGMIPGSW QHKMKLQLIL KSSKAYYVLS
710 720 730 740 750
DAAMSLQKYG RALRYIKLAL QSHDTYCCLC TNMLSEVLLF LSQYLTLCGD
760 770 780 790 800
IQLMLAQNAN NRAAHLEEFH YQTKEDQEIL HSLHRESSCQ GFAWATDLST
810 820 830 840 850
DLESQLSVSC KCYEAANEIL QFSDLKSQNP EHYVQVLKRM GNIRNEIGVF
860 870 880 890 900
YMNQAAALQS ERLVSKSVSA AEQQLWKKSF SCFEKGIHNF ESIEDATNAA
910 920 930 940 950
LLLCNTGRLM RICAQAHCGA GDELKREFSP EEGLYYNKAI DYYLKALRSL
960 970 980 990 1000
GTRDIHPAVW DSVNWELSTT YFTMATLQQD YAPLSRKAQE QIEKEVSEAM
1010 1020 1030 1040 1050
MKSLKYCDVD SVSARQPLCQ YRAATIHHRL ASMYHSCLRN QVGDEHLRKQ
1060 1070 1080 1090 1100
HRVLADLHYS KAAKLFQLLK DAPCELLRVQ LERVAFAEFQ MTSQNSNVGK
1110 1120 1130 1140 1150
LKTLSGALDI MVRTEHAFQL IQKELIEEFG QPKSGDAAAA ADASPSLNRE
1160 1170 1180 1190 1200
EVMKLLSIFE SRLSFLLLQS IKLLSSTKKK TSNNIEDDTI LKTNKHIYSQ
1210 1220 1230
LLRATANKTA TLLERINVIV HLLGQLAAGS AASSNAVQ
Length:1,238
Mass (Da):138,528
Last modified:November 22, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B4D5130EB10CF95
GO
Isoform 2 (identifier: Q3B7T1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     793-796: AWAT → KTGK
     797-1238: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:796
Mass (Da):88,851
Checksum:iC3BA9B8B1A71B8CD
GO
Isoform 3 (identifier: Q3B7T1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     587-593: PSCAFPV → LCISSLP
     594-1238: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:593
Mass (Da):66,004
Checksum:iBF58C4A954507048
GO
Isoform 4 (identifier: Q3B7T1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-299: Missing.

Note: No experimental confirmation available.
Show »
Length:1,204
Mass (Da):134,881
Checksum:i02189CCD55CF0AF7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJ07E9PJ07_HUMAN
Erythroid differentiation-related f...
EDRF1
343Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y353H0Y353_HUMAN
Erythroid differentiation-related f...
EDRF1
317Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCS2H0YCS2_HUMAN
Erythroid differentiation-related f...
EDRF1
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCQ0H0YCQ0_HUMAN
Erythroid differentiation-related f...
EDRF1
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG37462 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti443E → G in AAH26172 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03586245N → S in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs143528650Ensembl.1
Natural variantiVAR_03586395L → F in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_035712266 – 299Missing in isoform 4. CuratedAdd BLAST34
Alternative sequenceiVSP_035713587 – 593PSCAFPV → LCISSLP in isoform 3. 1 Publication7
Alternative sequenceiVSP_035714594 – 1238Missing in isoform 3. 1 PublicationAdd BLAST645
Alternative sequenceiVSP_019531793 – 796AWAT → KTGK in isoform 2. 1 Publication4
Alternative sequenceiVSP_019532797 – 1238Missing in isoform 2. 1 PublicationAdd BLAST442

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL158835 Genomic DNA No translation available.
BC026172 mRNA Translation: AAH26172.1
BC105929 mRNA Translation: AAI05930.1
BC107479 mRNA Translation: AAI07480.1
AK314958 mRNA Translation: BAG37462.1 Different initiation.
AL050102 mRNA Translation: CAB43273.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55733.1 [Q3B7T1-1]
CCDS7646.1 [Q3B7T1-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
T08751

NCBI Reference Sequences

More...
RefSeqi
NP_001189367.1, NM_001202438.1 [Q3B7T1-1]
NP_056423.2, NM_015608.2 [Q3B7T1-5]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.468688

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337623; ENSP00000336727; ENSG00000107938 [Q3B7T1-5]
ENST00000356792; ENSP00000349244; ENSG00000107938 [Q3B7T1-1]
ENST00000368815; ENSP00000357805; ENSG00000107938 [Q3B7T1-4]
ENST00000419769; ENSP00000396544; ENSG00000107938 [Q3B7T1-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26098

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26098

UCSC genome browser

More...
UCSCi
uc001lio.2 human [Q3B7T1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158835 Genomic DNA No translation available.
BC026172 mRNA Translation: AAH26172.1
BC105929 mRNA Translation: AAI05930.1
BC107479 mRNA Translation: AAI07480.1
AK314958 mRNA Translation: BAG37462.1 Different initiation.
AL050102 mRNA Translation: CAB43273.1
CCDSiCCDS55733.1 [Q3B7T1-1]
CCDS7646.1 [Q3B7T1-5]
PIRiT08751
RefSeqiNP_001189367.1, NM_001202438.1 [Q3B7T1-1]
NP_056423.2, NM_015608.2 [Q3B7T1-5]
UniGeneiHs.468688

3D structure databases

ProteinModelPortaliQ3B7T1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117548, 52 interactors
IntActiQ3B7T1, 23 interactors
MINTiQ3B7T1
STRINGi9606.ENSP00000349244

PTM databases

iPTMnetiQ3B7T1
PhosphoSitePlusiQ3B7T1

Polymorphism and mutation databases

BioMutaiEDRF1
DMDMi109826957

Proteomic databases

EPDiQ3B7T1
jPOSTiQ3B7T1
MaxQBiQ3B7T1
PaxDbiQ3B7T1
PeptideAtlasiQ3B7T1
PRIDEiQ3B7T1
ProteomicsDBi61658
61659 [Q3B7T1-3]
61660 [Q3B7T1-4]
61661 [Q3B7T1-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337623; ENSP00000336727; ENSG00000107938 [Q3B7T1-5]
ENST00000356792; ENSP00000349244; ENSG00000107938 [Q3B7T1-1]
ENST00000368815; ENSP00000357805; ENSG00000107938 [Q3B7T1-4]
ENST00000419769; ENSP00000396544; ENSG00000107938 [Q3B7T1-3]
GeneIDi26098
KEGGihsa:26098
UCSCiuc001lio.2 human [Q3B7T1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26098
DisGeNETi26098
EuPathDBiHostDB:ENSG00000107938.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EDRF1
HGNCiHGNC:24640 EDRF1
HPAiHPA031820
neXtProtiNX_Q3B7T1
OpenTargetsiENSG00000107938
PharmGKBiPA134873666

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF2A Eukaryota
ENOG410XSWW LUCA
GeneTreeiENSGT00390000014797
HOVERGENiHBG081471
InParanoidiQ3B7T1
OMAiCGAGDEF
OrthoDBi323777at2759
PhylomeDBiQ3B7T1
TreeFamiTF324739

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EDRF1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26098
PMAP-CutDBiQ3B7T1

Protein Ontology

More...
PROi
PR:Q3B7T1

Gene expression databases

BgeeiENSG00000107938 Expressed in 221 organ(s), highest expression level in body of pancreas
CleanExiHS_C10orf137
ExpressionAtlasiQ3B7T1 baseline and differential
GenevisibleiQ3B7T1 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEDRF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3B7T1
Secondary accession number(s): B2RC65
, Q3KR40, Q4G190, Q5VZQ4, Q8IZ74, Q9Y3W4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 22, 2005
Last modified: January 16, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again