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Protein

Alanine racemase

Gene

Cag_1635

Organism
Chlorobium chlorochromatii (strain CaD3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Cag_1635)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei33Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Active sitei262Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei310Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCCHL340177:G1G4Y-1780-MONOMER
UniPathwayi
UPA00042;UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Cag_1635Imported
OrganismiChlorobium chlorochromatii (strain CaD3)Imported
Taxonomic identifieri340177 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000002708 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi340177.Cag_1635

Structurei

3D structure databases

ProteinModelPortaliQ3AQ37
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 366Ala_racemase_CInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit

Sequencei

Sequence statusi: Complete.

Q3AQ37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCEALISLEH LRGNVRALQA HLNGRAHIMG IVKANAYGHN VHFVASTLET
60 70 80 90 100
CGIHNFGVAN IHEALELKQG GALQKPATII AFASPLPSHL PYFIEHGITM
110 120 130 140 150
TLCDHATFVA ARDIAAALER PLQVHVKIDS GMGRLGVAPH EAMALLQAVD
160 170 180 190 200
ASPFLELTGV YTHFADSATP NSFTHQQLAI FKTIAAEYEH AAQRTICKHT
210 220 230 240 250
ANSGALLSLQ ASWCDMVRPG ILLYGYHPSQ ECPTQLNVQP VMQVQAKVMF
260 270 280 290 300
IKKVAAGTSI SYNRTWQAPT ERFIATIAAG YADGYHRLLS NNAAVLINGK
310 320 330 340 350
RYPQVGTVTM DQIMVDLGSS HSVQVGDSAV LFGWDTLSAN ELAAQAHTIS
360
YEMLCAVSAR VKRRVV
Length:366
Mass (Da):39,640
Last modified:November 22, 2005 - v1
Checksum:iC881D461F30B994D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000108 Genomic DNA Translation: ABB28888.1
RefSeqiWP_011362650.1, NC_007514.1

Genome annotation databases

EnsemblBacteriaiABB28888; ABB28888; Cag_1635
KEGGicch:Cag_1635

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000108 Genomic DNA Translation: ABB28888.1
RefSeqiWP_011362650.1, NC_007514.1

3D structure databases

ProteinModelPortaliQ3AQ37
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi340177.Cag_1635

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB28888; ABB28888; Cag_1635
KEGGicch:Cag_1635

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Enzyme and pathway databases

UniPathwayi
UPA00042;UER00497

BioCyciCCHL340177:G1G4Y-1780-MONOMER

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ3AQ37_CHLCH
AccessioniPrimary (citable) accession number: Q3AQ37
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 10, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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