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Protein

Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene

menH

Organism
Chlorobium chlorochromatii (strain CaD3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).UniRule annotationSAAS annotation

Catalytic activityi

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.UniRule annotationSAAS annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotationSAAS annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Isochorismate synthase MenF (menF)
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH)
  4. o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. no protein annotated in this organism
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidaseImported, Hydrolase, LyaseUniRule annotationSAAS annotation, Protease
Biological processMenaquinone biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCCHL340177:G1G4Y-1864-MONOMER
UniPathwayi
UPA00079

UPA01057;UER00900

Protein family/group databases

ESTHERichlch-q3apv4 MenH_SHCHC

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseUniRule annotation (EC:4.2.99.20UniRule annotation)
Short name:
SHCHC synthaseUniRule annotation
Gene namesi
Name:menHUniRule annotation
Ordered Locus Names:Cag_1720Imported
OrganismiChlorobium chlorochromatii (strain CaD3)Imported
Taxonomic identifieri340177 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000002708 Componenti: Chromosome

Interactioni

Subunit structurei

Monomer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi340177.Cag_1720

Structurei

3D structure databases

ProteinModelPortaliQ3APV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 257AB hydrolase-1InterPro annotationAdd BLAST238

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MenH family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107J5P Bacteria
COG0596 LUCA
HOGENOMiHOG000028072
KOiK08680
OMAiLNDWYQQ
OrthoDBiPOG091H05R7

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
HAMAPiMF_01660 MenH, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR022485 SHCHC_synthase_MenH
PfamiView protein in Pfam
PF12697 Abhydrolase_6, 1 hit
PRINTSiPR00111 ABHYDROLASE
SUPFAMiSSF53474 SSF53474, 1 hit
TIGRFAMsiTIGR03695 menH_SHCHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q3APV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIMQPPLHIE IIGNKALPKI VFLHGFLGSG RDWLPLAEML TSHYCCVLVD
60 70 80 90 100
LPGHGSATLS ASDEHHAYFT ATVEALATVI QPISPEPCRL VGYSMGGRIA
110 120 130 140 150
LALMLTHPEL FHQAVIVSAS PGLPTEEERA KRRAGDEGIA RKIERNFPDF
160 170 180 190 200
LEAWYQQPLF STLKNHPLFQ EIERKRAINN SESLAAALRL LGTGQQPSFW
210 220 230 240 250
DALSKCAVPT LFIAGEKDER YVAIARQMVK LAPHATLSIV PNCGHTLHIE
260
NKESFVEQLH TFFNQ
Length:265
Mass (Da):29,422
Last modified:November 22, 2005 - v1
Checksum:iD36006E75EA886E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000108 Genomic DNA Translation: ABB28971.1
RefSeqiWP_011362733.1, NC_007514.1

Genome annotation databases

EnsemblBacteriaiABB28971; ABB28971; Cag_1720
KEGGicch:Cag_1720

Similar proteinsi

Entry informationi

Entry nameiQ3APV4_CHLCH
AccessioniPrimary (citable) accession number: Q3APV4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: February 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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