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Protein

Probable molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21GTPUniRule annotation1
Binding sitei65GTPUniRule annotation1
Metal bindingi94MagnesiumUniRule annotation1
Binding sitei94GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 11GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCHYD246194:G1G5B-790-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:CHY_0866
OrganismiCarboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
Proteomesi
  • UP000002706 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000191161 – 197Probable molybdenum cofactor guanylyltransferaseAdd BLAST197

Interactioni

Protein-protein interaction databases

STRINGi246194.CHY_0866.

Structurei

3D structure databases

ProteinModelPortaliQ3ADR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6R. Bacteria.
COG0746. LUCA.
HOGENOMiHOG000280425.
KOiK03752.
OMAiLFNCNTP.
OrthoDBiPOG091H05CW.

Family and domain databases

CDDicd02503. MobA. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA. 1 hit.
InterProiView protein in InterPro
IPR025877. MobA-like_NTP_Trfase.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
PfamiView protein in Pfam
PF12804. NTP_transf_3. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ADR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNLTVAILA GGKSSRMGQN KALLPLGTMK IIEHLVTNLR PIASELLLVA
60 70 80 90 100
NTDEYAFLNL PVYRDRFPGQ GPLAGIETAL RVAFNEKVYI TACDLPLLPA
110 120 130 140 150
EIPRFLAENT EDYDVTVLAY KGKIEPLIGI YRKSIYPVVE KHLILRKNKI
160 170 180 190
IDFYPQVKVK IINFEQLPEN LQREEFLLNV NTPADYEKLL KIFSLKE
Length:197
Mass (Da):22,383
Last modified:November 22, 2005 - v1
Checksum:i2D836D1F1333267C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA. Translation: ABB14248.1.
RefSeqiWP_011343793.1. NC_007503.1.

Genome annotation databases

EnsemblBacteriaiABB14248; ABB14248; CHY_0866.
KEGGichy:CHY_0866.

Similar proteinsi

Entry informationi

Entry nameiMOBA_CARHZ
AccessioniPrimary (citable) accession number: Q3ADR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: February 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome