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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase (dapL)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei13SubstrateUniRule annotation1
Binding sitei38Substrate; via amide nitrogenUniRule annotation1
Binding sitei102SubstrateUniRule annotation1
Binding sitei126Pyridoxal phosphateUniRule annotation1
Binding sitei126SubstrateUniRule annotation1
Binding sitei176Pyridoxal phosphateUniRule annotation1
Binding sitei176SubstrateUniRule annotation1
Binding sitei207Pyridoxal phosphateUniRule annotation1
Binding sitei246Pyridoxal phosphateUniRule annotation1
Binding sitei364SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciCHYD246194:G1G5B-1392-MONOMER
UniPathwayi
UPA00034;UER00466

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotation
Ordered Locus Names:CHY_1492
OrganismiCarboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
Proteomesi
  • UP000002706 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422171 – 390LL-diaminopimelate aminotransferaseAdd BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei238N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ3AC10

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi246194.CHY_1492

Structurei

3D structure databases

ProteinModelPortaliQ3AC10
SMRiQ3AC10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni101 – 102Pyridoxal phosphate bindingUniRule annotation2
Regioni235 – 237Pyridoxal phosphate bindingUniRule annotation3

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHM Bacteria
COG0436 LUCA
HOGENOMiHOG000223051
KOiK10206
OMAiPYAFINP
OrthoDBiPOG091H09WQ

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019881 DAP-NH2Trfase_DapL_Desulfo
IPR019942 DapL/ALD1
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03540 DapC_direct, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q3AC10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEATRVRNL PPYLFARIER LIAEKKEAGV DVISLGIGDP DTPTPKHIIE
60 70 80 90 100
ELYLAAQNPE NHQYPSSVGM LSYRQAVAAW YARRFGVELD PKTEVVSLLG
110 120 130 140 150
SKEGIAHISW CYVDPGDLVL VPDPGYPVYE GGTILAGGTT YKMPLKPENG
160 170 180 190 200
FLPDLDSIPE EVARKAKLMF INYPNNPTGA VADLGFFEKV VHFAKKYEIL
210 220 230 240 250
VCHDAAYSEI TFDGYRAPSF LEVKGAKDVG IEFHSLSKTY NMTGWRIGWA
260 270 280 290 300
VGNAKAIDAL GRLKSNIDSG VFQAIQYAGI KALEGPQDVV KELCDLYAQR
310 320 330 340 350
RDLVIETLNK LGWNLSKPKG TFYIWAPVPK GFTSASFAEY LIEKAGVVIT
360 370 380 390
PGNGYGTNGE GYFRISLTIP TSRLKEALQR IEQHLGKVEF
Length:390
Mass (Da):43,112
Last modified:November 22, 2005 - v1
Checksum:i1ABA54D7A14DCBA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA Translation: ABB16059.1
RefSeqiWP_011344399.1, NC_007503.1

Genome annotation databases

EnsemblBacteriaiABB16059; ABB16059; CHY_1492
KEGGichy:CHY_1492

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA Translation: ABB16059.1
RefSeqiWP_011344399.1, NC_007503.1

3D structure databases

ProteinModelPortaliQ3AC10
SMRiQ3AC10
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246194.CHY_1492

Proteomic databases

PRIDEiQ3AC10

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB16059; ABB16059; CHY_1492
KEGGichy:CHY_1492

Phylogenomic databases

eggNOGiENOG4105CHM Bacteria
COG0436 LUCA
HOGENOMiHOG000223051
KOiK10206
OMAiPYAFINP
OrthoDBiPOG091H09WQ

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

BioCyciCHYD246194:G1G5B-1392-MONOMER

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019881 DAP-NH2Trfase_DapL_Desulfo
IPR019942 DapL/ALD1
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03540 DapC_direct, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAPAT_CARHZ
AccessioniPrimary (citable) accession number: Q3AC10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: November 22, 2005
Last modified: October 10, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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