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Entry version 102 (16 Oct 2019)
Sequence version 1 (22 Nov 2005)
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Protein

NADH-quinone oxidoreductase subunit B/C/D

Gene

nuoBCD

Organism
Pelobacter carbinolicus (strain DSM 2380 / NBRC 103641 / GraBd1)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMultifunctional enzyme, Translocase
Biological processTransport
LigandNAD, Ubiquinone

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PCAR338963:G1G5C-220-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit B/C/D (EC:7.1.1.-)
Alternative name(s):
NADH dehydrogenase I subunit B/C/D
NDH-1 subunit B/C/D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nuoBCD
Synonyms:nuoB, nuoC, nuoD
Ordered Locus Names:Pcar_0206
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPelobacter carbinolicus (strain DSM 2380 / NBRC 103641 / GraBd1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri338963 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesDesulfuromonadaceaePelobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002534 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003586521 – 794NADH-quinone oxidoreductase subunit B/C/DAdd BLAST794

Keywords - PTMi

Quinone

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q3A825

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

NDH-1 is composed of about 13 different subunits. Subunits NuoBCD, E, F, and G constitute the peripheral sector of the complex (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
338963.Pcar_0206

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3A825

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 154NADH dehydrogenase I subunit BBy similarityAdd BLAST154
Regioni230 – 383NADH dehydrogenase I subunit CBy similarityAdd BLAST154
Regioni414 – 794NADH dehydrogenase I subunit DBy similarityAdd BLAST381

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the complex I 20 kDa subunit family.Curated
In the central section; belongs to the complex I 30 kDa subunit family.Curated
In the C-terminal section; belongs to the complex I 49 kDa subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CQV Bacteria
COG0377 LUCA
COG0649 LUCA
COG0852 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000228264

KEGG Orthology (KO)

More...
KOi
K13380

Identification of Orthologs from Complete Genome Data

More...
OMAi
GGRMHYM

Database of Orthologous Groups

More...
OrthoDBi
473681at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.645.20, 1 hit
3.30.460.80, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01356 NDH1_NuoB, 1 hit
MF_01357 NDH1_NuoC, 1 hit
MF_01358 NDH1_NuoD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010218 NADH_DH_suC
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR037232 NADH_quin_OxRdtase_su_C/D-like
IPR006137 NADH_UbQ_OxRdtase-like_20kDa
IPR001268 NADH_UbQ_OxRdtase_30kDa_su
IPR014029 NADH_UbQ_OxRdtase_49kDa_CS
IPR020396 NADH_UbQ_OxRdtase_CS
IPR006138 NADH_UQ_OxRdtase_20Kd_su
IPR022885 NDH1_su_D/H
IPR029014 NiFe-Hase_large

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00329 Complex1_30kDa, 1 hit
PF00346 Complex1_49kDa, 1 hit
PF01058 Oxidored_q6, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143243 SSF143243, 1 hit
SSF56762 SSF56762, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01957 nuoB_fam, 1 hit
TIGR01961 NuoC_fam, 1 hit
TIGR01962 NuoD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00542 COMPLEX1_30K, 1 hit
PS00535 COMPLEX1_49K, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3A825-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSESIPKNII LTTLDDAINW GRKNSMWPMF FGLSCCFVEM MGSMTPRFDL
60 70 80 90 100
ARFGAEVLRG TPREADLMVI AGTPFKKMAA SMLRVYEEMA NPKWVIAMGS
110 120 130 140 150
CANSGGMYDV YSVMQGVNQV LPVDVYIPGC PPRPEAFMQG LMTLQEKIAR
160 170 180 190 200
KESPARPVLN LRGGNEGTTV PILIDGSSKT RDTRGPGYGH CPIRGTAQQH
210 220 230 240 250
PDFKGHRAAG MWGPPQPKIA FSASTAPLLE QLRERFGDDV RQEEGADMPT
260 270 280 290 300
LVADPAQVPE LLRFLKQDID QPYERLEDLT AIDETARSQR PAHDLTMVYH
310 320 330 340 350
LLSFERAGYL RVKAPLRNDR AEVPSITGLW PAANWYEREA FDMFGVRFAG
360 370 380 390 400
HPDLRRILMP EGWQGHPLRK SHPSRATDMP PFTRDTATTM VPPEGSHFFS
410 420 430 440 450
NRAPVDNQSL SILNLGPQHP GTHGILRVIL QLAGEEIVDL DSEIGYHHRG
460 470 480 490 500
AEKIAERQHW NQYIPYTDRI DYLAGSLNNL AYLYSVETLC GVEVPPRARY
510 520 530 540 550
IRVLLSELFR IASHLVWLGT FAHDVGAMTP VFYAFDSREK IFDIIELITG
560 570 580 590 600
GRMHPAWFRI GGVPDDLPDG WLAAVEAFTR DFEARIDEFD RLLTGGPIFR
610 620 630 640 650
ARTEGIGTVS RQQAVELGFS GPNLRATGLA WDLRKSMPYG GYDEFDFDVV
660 670 680 690 700
TAGGGDCFAR YLVRLGELRQ SLRIVRQAAE GMPQGRWISD QYRYAYPKRE
710 720 730 740 750
DGLQDIESLI HHFLHVSRGP AAPRGECYRA IESSKGECGY YAVSDGGTGA
760 770 780 790
YRLRIRTPSF PHLQALPQLS RGRLVADVIT ILGSLDYVLA DLDR
Length:794
Mass (Da):88,844
Last modified:November 22, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61FB467B9AC50FC4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000142 Genomic DNA Translation: ABA87467.1

NCBI Reference Sequences

More...
RefSeqi
WP_011339867.1, NC_007498.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABA87467; ABA87467; Pcar_0206

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pca:Pcar_0206

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000142 Genomic DNA Translation: ABA87467.1
RefSeqiWP_011339867.1, NC_007498.2

3D structure databases

SMRiQ3A825
ModBaseiSearch...

Protein-protein interaction databases

STRINGi338963.Pcar_0206

Proteomic databases

PRIDEiQ3A825

Genome annotation databases

EnsemblBacteriaiABA87467; ABA87467; Pcar_0206
KEGGipca:Pcar_0206

Phylogenomic databases

eggNOGiENOG4105CQV Bacteria
COG0377 LUCA
COG0649 LUCA
COG0852 LUCA
HOGENOMiHOG000228264
KOiK13380
OMAiGGRMHYM
OrthoDBi473681at2

Enzyme and pathway databases

BioCyciPCAR338963:G1G5C-220-MONOMER

Family and domain databases

Gene3Di1.10.645.20, 1 hit
3.30.460.80, 1 hit
HAMAPiMF_01356 NDH1_NuoB, 1 hit
MF_01357 NDH1_NuoC, 1 hit
MF_01358 NDH1_NuoD, 1 hit
InterProiView protein in InterPro
IPR010218 NADH_DH_suC
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR037232 NADH_quin_OxRdtase_su_C/D-like
IPR006137 NADH_UbQ_OxRdtase-like_20kDa
IPR001268 NADH_UbQ_OxRdtase_30kDa_su
IPR014029 NADH_UbQ_OxRdtase_49kDa_CS
IPR020396 NADH_UbQ_OxRdtase_CS
IPR006138 NADH_UQ_OxRdtase_20Kd_su
IPR022885 NDH1_su_D/H
IPR029014 NiFe-Hase_large
PfamiView protein in Pfam
PF00329 Complex1_30kDa, 1 hit
PF00346 Complex1_49kDa, 1 hit
PF01058 Oxidored_q6, 1 hit
SUPFAMiSSF143243 SSF143243, 1 hit
SSF56762 SSF56762, 1 hit
TIGRFAMsiTIGR01957 nuoB_fam, 1 hit
TIGR01961 NuoC_fam, 1 hit
TIGR01962 NuoD, 1 hit
PROSITEiView protein in PROSITE
PS00542 COMPLEX1_30K, 1 hit
PS00535 COMPLEX1_49K, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUBCD_PELCD
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3A825
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: November 22, 2005
Last modified: October 16, 2019
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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