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Protein

Argininosuccinate lyase

Gene

argH

Organism
Pelobacter carbinolicus (strain DSM 2380 / NBRC 103641 / GraBd1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciPCAR338963:G1G5C-2543-MONOMER
UniPathwayi
UPA00068;UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Pcar_2418
OrganismiPelobacter carbinolicus (strain DSM 2380 / NBRC 103641 / GraBd1)
Taxonomic identifieri338963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesDesulfuromonadaceaePelobacter
Proteomesi
  • UP000002534 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002407471 – 461Argininosuccinate lyaseAdd BLAST461

Interactioni

Protein-protein interaction databases

STRINGi338963.Pcar_2418

Structurei

3D structure databases

ProteinModelPortaliQ3A1V0
SMRiQ3A1V0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiKKNPDVF
OrthoDBiPOG091H026A

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q3A1V0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKKPWAGRF TQPTDAFVEA FTASIDFDQR LYRYDIQGSM AHARMLSRQG
60 70 80 90 100
IITGAEAQTI ISGLESILAD IEKGDFEFSV ALEDIHMNIE ARLIERIGSV
110 120 130 140 150
GGKLHTARSR NDQVALDIRL YLRDEVKEVR SFLEKVQESL LEQAERNLGV
160 170 180 190 200
IMPGYTHLQT AQPILFSHHM MAYYEMFRRD SWRMADIYKR INLLPLGAGA
210 220 230 240 250
LAGTTFPIDR EYVAEQLGFD GVTRNSLDSV SDRDFALEFC SAASVVMMHL
260 270 280 290 300
SRLSEELILW SSADFHFIDL SDAFCTGSSI MPQKKNPDVP ELVRGKTGRV
310 320 330 340 350
YGNLMSLLTV MKALPLAYNK DMQEDKEPLF DTIDTVKGSL KIFADMIAQM
360 370 380 390 400
SIRADNMREA AARGFSTATD VADYVVRKGI PFRDAHEIVG KTVRYCIEHD
410 420 430 440 450
KQIEELTLEE FKAFSEHIDS DIYDFITLEA SVDSRRATGG TAREAVAREI
460
GRARQERLQR M
Length:461
Mass (Da):52,131
Last modified:November 22, 2005 - v1
Checksum:iB21F6DD0912596B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000142 Genomic DNA Translation: ABA89657.1
RefSeqiWP_011342183.1, NC_007498.2

Genome annotation databases

EnsemblBacteriaiABA89657; ABA89657; Pcar_2418
KEGGipca:Pcar_2418

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000142 Genomic DNA Translation: ABA89657.1
RefSeqiWP_011342183.1, NC_007498.2

3D structure databases

ProteinModelPortaliQ3A1V0
SMRiQ3A1V0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi338963.Pcar_2418

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA89657; ABA89657; Pcar_2418
KEGGipca:Pcar_2418

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiKKNPDVF
OrthoDBiPOG091H026A

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00114

BioCyciPCAR338963:G1G5C-2543-MONOMER

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARLY_PELCD
AccessioniPrimary (citable) accession number: Q3A1V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 22, 2005
Last modified: November 7, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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