Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Shikimate kinase

Gene

aroK

Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.UniRule annotation

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (VL00_02860), Phospho-2-dehydro-3-deoxyheptonate aldolase (WI95_29895), Phospho-2-dehydro-3-deoxyheptonate aldolase (VL00_14265), Phospho-2-dehydro-3-deoxyheptonate aldolase (Bcep18194_A3826), Phospho-2-dehydro-3-deoxyheptonate aldolase (VL00_21645), Phospho-2-dehydro-3-deoxyheptonate aldolase (VL00_13870), Phospho-2-dehydro-3-deoxyheptonate aldolase (Bcep18194_B0086)
  2. 3-dehydroquinate synthase (aroB), 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK), Shikimate kinase (aroK), Shikimate kinase (aroK), Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA), 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC), Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi21MagnesiumUniRule annotation1
Binding sitei39SubstrateUniRule annotation1
Binding sitei63SubstrateUniRule annotation1
Binding sitei85Substrate; via amide nitrogenUniRule annotation1
Binding sitei123ATPUniRule annotation1
Binding sitei142SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 22ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00053; UER00088

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
Short name:
SKUniRule annotation
Gene namesi
Name:aroKUniRule annotation
Ordered Locus Names:Bcep18194_A3489
OrganismiBurkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002378601 – 184Shikimate kinaseAdd BLAST184

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ39KC5
SMRiQ39KC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000032568
KOiK00891
OMAiHGEPHFR
OrthoDBiPOG091H02J5

Family and domain databases

CDDicd00464 SK, 1 hit
HAMAPiMF_00109 Shikimate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR031322 Shikimate/glucono_kinase
IPR000623 Shikimate_kinase/TSH1
IPR023000 Shikimate_kinase_CS
PfamiView protein in Pfam
PF01202 SKI, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS01128 SHIKIMATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q39KC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQARDPHANV FFVGLMGAGK TTVGRAVARR LDRTFFDSDH EIEARTGARI
60 70 80 90 100
PVIFEMEGEA GFRDRETQVI TDLTQRENIV LATGGGAVLR PENRDCLKNN
110 120 130 140 150
GIVVYLRANP HDLWLRTRKD KNRPLLQTED PKGRLEALYE VRDPLYRECA
160 170 180
DFVIETGRPS VNGLVNMVLM QLELAGVIAK PLQA
Length:184
Mass (Da):20,670
Last modified:November 22, 2005 - v1
Checksum:iF37300A7FF205502
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA Translation: ABB07091.1
RefSeqiWP_011350694.1, NC_007510.1

Genome annotation databases

EnsemblBacteriaiABB07091; ABB07091; Bcep18194_A3489
KEGGibur:Bcep18194_A3489
PATRICifig|482957.22.peg.332

Similar proteinsi

Entry informationi

Entry nameiAROK_BURL3
AccessioniPrimary (citable) accession number: Q39KC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 22, 2005
Last modified: October 25, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health