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Protein

Molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei27GTPUniRule annotation1
Binding sitei77GTPUniRule annotation1
Metal bindingi107MagnesiumUniRule annotation1
Binding sitei107GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 16GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:Bcep18194_A4221
OrganismiBurkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000191111 – 205Molybdenum cofactor guanylyltransferaseAdd BLAST205

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ39I98.
SMRiQ39I98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000280423.
KOiK03752.
OMAiFVPCDVP.
OrthoDBiPOG091H05CW.

Family and domain databases

CDDicd02503. MobA. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA. 1 hit.
InterProiView protein in InterPro
IPR025877. MobA-like_NTP_Trfase.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
PfamiView protein in Pfam
PF12804. NTP_transf_3. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR02665. molyb_mobA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q39I98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASASPSIA GLLLAGGRAT RMDGVDKGLQ LLDGTPLALH VLSRLSPQVD
60 70 80 90 100
ETLISANRHA DRYAELGAPF DARIVADETP DFPGPLAGLL AGMRAARAPL
110 120 130 140 150
VACSPCDTPY LPADLVARLQ AALDAQQADI AMAVTVDAQH VRSPQPTFAL
160 170 180 190 200
LRTSLADDLA ARLAAGDRKV RAWYARHKTV EVEFHDERAF YNANSWQELA

ALARR
Length:205
Mass (Da):21,928
Last modified:November 22, 2005 - v1
Checksum:i643AF0A597308F48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000151 Genomic DNA. Translation: ABB07818.1.
RefSeqiWP_011351392.1. NC_007510.1.

Genome annotation databases

EnsemblBacteriaiABB07818; ABB07818; Bcep18194_A4221.
KEGGibur:Bcep18194_A4221.
PATRICifig|482957.22.peg.1112.

Similar proteinsi

Entry informationi

Entry nameiMOBA_BURL3
AccessioniPrimary (citable) accession number: Q39I98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: October 25, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome