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Protein

Vetispiradiene synthase 2

Gene
N/A
Organism
Hyoscyamus muticus (Egyptian henbane)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sesquiterpene synthase that catalyzes the formation of vetispiradiene from trans,trans-farnesyl diphosphate. The initial internal cyclization produces the monocyclic intermediate germacrene A.

Catalytic activityi

(2E,6E)-farnesyl diphosphate = vetispiradiene + diphosphate.1 Publication

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathwayi: terpenoid biosynthesis

This protein is involved in the pathway terpenoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway terpenoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Magnesium 1By similarity1
Metal bindingi54Magnesium 2By similarity1
Metal bindingi58Magnesium 1By similarity1
Metal bindingi58Magnesium 2By similarity1
Metal bindingi197Magnesium 3By similarity1
Metal bindingi201Magnesium 3By similarity1
Metal bindingi205Magnesium 3By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00213

Names & Taxonomyi

Protein namesi
Recommended name:
Vetispiradiene synthase 2 (EC:4.2.3.21)
Short name:
HVS2
OrganismiHyoscyamus muticus (Egyptian henbane)
Taxonomic identifieri35626 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeHyoscyameaeHyoscyamus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000398185‹1 – 300Vetispiradiene synthase 2Add BLAST›300

Expressioni

Inductioni

By elicitor from R.solani.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ39979
SMRiQ39979
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi54 – 58DDXXD motif5

Domaini

The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg2+.

Sequence similaritiesi

Belongs to the terpene synthase family. Tpsa subfamily.Curated

Phylogenomic databases

KOiK14182

Family and domain databases

Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR034741 Terpene_cyclase_like_1_C
IPR005630 Terpene_synthase_metal-bd
PfamiView protein in Pfam
PF03936 Terpene_synth_C, 1 hit
SFLDiSFLDG01019 Terpene_Cyclase_Like_1_C_Termi, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit

Sequencei

Sequence statusi: Fragment.

Q39979-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SRWWKDLDFV TTLPYARDRA VECYFWTMGV YAEPQYSQAR VMLAKTIAMI
60 70 80 90 100
SIVDDTFDAY GIVKEFEVYT DAIQRWDISQ IDRLPEYMKI SYKALLDLYD
110 120 130 140 150
DYEKELSKDG RSDVVHYAKE RMKEIVRNYF IEAKWFIEGY MPSVSEYLSN
160 170 180 190 200
ALATSTYYLL TTTSYLGMKS ATKEHFEWLA TNPKILEANA TLCRVVDDIA
210 220 230 240 250
TYEVEKGRGQ IATGIECYMR DYGVSTEVAM EKFQEMAEIA WKDVNEEILR
260 270 280 290 300
PTPVSAEILT RILNLARIID VTYKHNQDGY THPEKFKPHI IALLVDSIEI
Length:300
Mass (Da):34,959
Last modified:November 1, 1996 - v1
Checksum:i9F60D2BAB580A79D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20189 mRNA Translation: AAA86338.1
PIRiB56118

Genome annotation databases

KEGGiag:AAA86338

Similar proteinsi

Entry informationi

Entry nameiVTSS2_HYOMU
AccessioniPrimary (citable) accession number: Q39979
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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