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Entry version 127 (23 Feb 2022)
Sequence version 2 (09 Jan 2007)
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Protein

Vacuolar cation/proton exchanger 2

Gene

CAX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Vacuolar cation/proton exchanger (CAX). Translocates Ca2+ and other metal ions into vacuoles using the proton gradient formed by H+-ATPase and H+-pyrophosphatase.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by excess of Ca2+ and Cd2+, Mn2+, and Zn2+.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7.0 for cytosolic pH.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Calcium transport, Ion transport, Transport
LigandCalcium

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.19.2.4, the ca(2+):cation antiporter (caca) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar cation/proton exchanger 2
Alternative name(s):
Ca(2+)/H(+) antiporter CAX2
Ca(2+)/H(+) exchanger 2
Protein CATION EXCHANGER 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAX2
Ordered Locus Names:At3g13320
ORF Names:MDC11.10, MDC11.19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G13320

The Arabidopsis Information Resource

More...
TAIRi
locus:2088130, AT3G13320

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 69CytoplasmicSequence analysisAdd BLAST69
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 97ExtracellularSequence analysis7
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 129CytoplasmicSequence analysisAdd BLAST11
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Topological domaini151 – 166ExtracellularSequence analysisAdd BLAST16
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 196CytoplasmicSequence analysis9
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 231ExtracellularSequence analysisAdd BLAST14
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 286CytoplasmicSequence analysisAdd BLAST34
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 311ExtracellularSequence analysis4
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 354CytoplasmicSequence analysisAdd BLAST22
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 384ExtracellularSequence analysis9
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 412CytoplasmicSequence analysis7
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 441ExtracellularSequence analysis8

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi67 – 75SIKIVIFCN → NLQEVILGT: Loss of Mn(2+) transport. 9
Mutagenesisi89 – 97LVHYMIDSK → ICTYCGVSQ: Facilitates Ca(2+)/H(+) exchange activity. 1 Publication9
Mutagenesisi152 – 162KNGMIRVVQLT → TNNKVAVVKYS: Loss of Mn(2+) transport. 1 PublicationAdd BLAST11
Mutagenesisi177 – 186CAFFCGGLVF → TSLFCGGIAN: Loss of Mn(2+) transport. 1 Publication10
Mutagenesisi222H → A: Loss of transport activity. 1 Publication1
Mutagenesisi222H → D: Loss of transport activity. 1 Publication1
Mutagenesisi222H → K: No effect on transport activity. 1 Publication1
Mutagenesisi226H → A: No effect on transport activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002701511 – 441Vacuolar cation/proton exchanger 2Add BLAST441

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q39254

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
223885

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q39254, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q39254, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
5866, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q39254, 5 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT3G13320.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q39254

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni139 – 174Cation selectionSequence analysisAdd BLAST36
Regioni333 – 368Cation selectionSequence analysisAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1397, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008721_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q39254

Identification of Orthologs from Complete Genome Data

More...
OMAi
AIMTAWI

Database of Orthologous Groups

More...
OrthoDBi
727723at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q39254

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1420.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004713, CaH_exchang
IPR004798, CAX-like
IPR004837, NaCa_Exmemb
IPR044880, NCX_ion-bd_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR31503, PTHR31503, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01699, Na_Ca_ex, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00378, cax, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q39254-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCCKVPVLI EAQVEMVSAN ELENKSLFRQ EEDATQTKEA SLMEQGSLST
60 70 80 90 100
SFPQHTPKAP KNSVLNSIKI VIFCNKLNLL LPFGPLAILV HYMIDSKGWV
110 120 130 140 150
FLLTLVGITP LAERLGYATE QLACYTGPTV GGLLNATFGN VTELIISIFA
160 170 180 190 200
LKNGMIRVVQ LTLLGSILSN MLLVLGCAFF CGGLVFYQKD QVFDKGIATV
210 220 230 240 250
NSGLLLMAVM GILFPAVLHY THSEVHAGSS ELALSRFSSC IMLIAYAAYL
260 270 280 290 300
FFQLKSQSNS YSPLDEESNQ NEETSAEDED PEISKWEAII WLSILTAWVS
310 320 330 340 350
LLSGYLVDAI EGASVSWNIP IAFISTILLP IVGNAAEHAG AIMFAMKDKL
360 370 380 390 400
DLSLGVAIGS SIQISMFAVP FCVVIGWMMG QQMDLNFQLF ETAMLFITVI
410 420 430 440
VVAFFLQEGS SNYFKGLMLI LCYLIVAASF FVHEDPHQDG I
Length:441
Mass (Da):48,215
Last modified:January 9, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CDA37D374184605
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB02801 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135N → G in AAB05914 (PubMed:8710949).Curated1
Sequence conflicti177 – 178CA → LR in AAB05914 (PubMed:8710949).Curated2
Sequence conflicti369 – 372VPFC → RPIL in AAB05914 (PubMed:8710949).Curated4
Sequence conflicti393A → P in AAB05914 (PubMed:8710949).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB024034 Genomic DNA Translation: BAB02801.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE75333.1
AF424628 mRNA Translation: AAL11621.1
AY097343 mRNA Translation: AAM19859.1
U57412 mRNA Translation: AAB05914.1

NCBI Reference Sequences

More...
RefSeqi
NP_566452.1, NM_112177.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G13320.1; AT3G13320.1; AT3G13320

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
820532

Gramene; a comparative resource for plants

More...
Gramenei
AT3G13320.1; AT3G13320.1; AT3G13320

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT3G13320

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024034 Genomic DNA Translation: BAB02801.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE75333.1
AF424628 mRNA Translation: AAL11621.1
AY097343 mRNA Translation: AAM19859.1
U57412 mRNA Translation: AAB05914.1
RefSeqiNP_566452.1, NM_112177.3

3D structure databases

SMRiQ39254
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi5866, 5 interactors
IntActiQ39254, 5 interactors
STRINGi3702.AT3G13320.1

Protein family/group databases

TCDBi2.A.19.2.4, the ca(2+):cation antiporter (caca) family

Proteomic databases

PaxDbiQ39254
ProteomicsDBi223885

Genome annotation databases

EnsemblPlantsiAT3G13320.1; AT3G13320.1; AT3G13320
GeneIDi820532
GrameneiAT3G13320.1; AT3G13320.1; AT3G13320
KEGGiath:AT3G13320

Organism-specific databases

AraportiAT3G13320
TAIRilocus:2088130, AT3G13320

Phylogenomic databases

eggNOGiKOG1397, Eukaryota
HOGENOMiCLU_008721_2_1_1
InParanoidiQ39254
OMAiAIMTAWI
OrthoDBi727723at2759
PhylomeDBiQ39254

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q39254

Gene expression databases

ExpressionAtlasiQ39254, baseline and differential
GenevisibleiQ39254, AT

Family and domain databases

Gene3Di1.20.1420.30, 2 hits
InterProiView protein in InterPro
IPR004713, CaH_exchang
IPR004798, CAX-like
IPR004837, NaCa_Exmemb
IPR044880, NCX_ion-bd_dom_sf
PANTHERiPTHR31503, PTHR31503, 1 hit
PfamiView protein in Pfam
PF01699, Na_Ca_ex, 2 hits
TIGRFAMsiTIGR00378, cax, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAX2_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q39254
Secondary accession number(s): Q944Q1, Q9LTT6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: February 23, 2022
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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