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Entry version 133 (18 Sep 2019)
Sequence version 2 (23 Jan 2002)
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Protein

Transcription initiation factor IIA subunit 2

Gene

TFIIA-S

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor IIA subunit 2
Alternative name(s):
General transcription factor IIA subunit 2
Transcription initiation factor IIA gamma chain
Short name:
TFIIA-gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TFIIA-S
Ordered Locus Names:At4g24440
ORF Names:T22A6.270
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G24440

The Arabidopsis Information Resource

More...
TAIRi
locus:2136017 AT4G24440

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001940501 – 106Transcription initiation factor IIA subunit 2Add BLAST106

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q39236

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q39236

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q39236 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q39236 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha, a beta and a gamma subunit (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
13835, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q39236, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT4G24440.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q39236

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFIIA subunit 2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3463 Eukaryota
COG5123 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000167251

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q39236

KEGG Orthology (KO)

More...
KOi
K03123

Identification of Orthologs from Complete Genome Data

More...
OMAi
ATAYYEF

Database of Orthologous Groups

More...
OrthoDBi
1589933at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q39236

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10014 TFIIA_gamma_C, 1 hit
cd10145 TFIIA_gamma_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.190, 1 hit
2.30.18.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009083 TFIIA_a-hlx
IPR009088 TFIIA_b-brl
IPR003194 TFIIA_gsu
IPR015871 TFIIA_gsu_C
IPR015872 TFIIA_gsu_N

The PANTHER Classification System

More...
PANTHERi
PTHR10966 PTHR10966, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02751 TFIIA_gamma_C, 1 hit
PF02268 TFIIA_gamma_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF009415 Hum_TFIIA_gamma, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50784 SSF50784, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q39236-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATFELYRRS TIGMCLTETL DEMVQSGTLS PELAIQVLVQ FDKSMTEALE
60 70 80 90 100
SQVKTKVSIK GHLHTYRFCD NVWTFILQDA MFKSDDRQEN VSRVKIVACD

SKLLTQ
Length:106
Mass (Da):12,140
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB466F2E1EC68534
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29L → V in CAA67369 (Ref. 1) Curated1
Sequence conflicti65 – 69TYRFC → HLQVR in CAA67369 (Ref. 1) Curated5
Sequence conflicti85D → Y in CAA67369 (Ref. 1) Curated1
Sequence conflicti93R → P in CAA67369 (Ref. 1) Curated1
Sequence conflicti99C → S in CAA67369 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X98862 mRNA Translation: CAA67369.1
AJ223634 mRNA Translation: CAA11524.1
AL078637 Genomic DNA Translation: CAB45079.1
AL161561 Genomic DNA Translation: CAB79354.1
CP002687 Genomic DNA Translation: AEE84904.1
CP002687 Genomic DNA Translation: AEE84905.1
AY072192 mRNA Translation: AAL60014.1
AY096423 mRNA Translation: AAM20063.1
AY085740 mRNA Translation: AAM62958.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T09907

NCBI Reference Sequences

More...
RefSeqi
NP_194175.1, NM_118577.5
NP_849434.1, NM_179103.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G24440.1; AT4G24440.1; AT4G24440
AT4G24440.2; AT4G24440.2; AT4G24440

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
828546

Gramene; a comparative resource for plants

More...
Gramenei
AT4G24440.1; AT4G24440.1; AT4G24440
AT4G24440.2; AT4G24440.2; AT4G24440

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G24440

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98862 mRNA Translation: CAA67369.1
AJ223634 mRNA Translation: CAA11524.1
AL078637 Genomic DNA Translation: CAB45079.1
AL161561 Genomic DNA Translation: CAB79354.1
CP002687 Genomic DNA Translation: AEE84904.1
CP002687 Genomic DNA Translation: AEE84905.1
AY072192 mRNA Translation: AAL60014.1
AY096423 mRNA Translation: AAM20063.1
AY085740 mRNA Translation: AAM62958.1
PIRiT09907
RefSeqiNP_194175.1, NM_118577.5
NP_849434.1, NM_179103.3

3D structure databases

SMRiQ39236
ModBaseiSearch...

Protein-protein interaction databases

BioGridi13835, 1 interactor
IntActiQ39236, 1 interactor
STRINGi3702.AT4G24440.1

PTM databases

iPTMnetiQ39236

Proteomic databases

PaxDbiQ39236

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G24440.1; AT4G24440.1; AT4G24440
AT4G24440.2; AT4G24440.2; AT4G24440
GeneIDi828546
GrameneiAT4G24440.1; AT4G24440.1; AT4G24440
AT4G24440.2; AT4G24440.2; AT4G24440
KEGGiath:AT4G24440

Organism-specific databases

AraportiAT4G24440
TAIRilocus:2136017 AT4G24440

Phylogenomic databases

eggNOGiKOG3463 Eukaryota
COG5123 LUCA
HOGENOMiHOG000167251
InParanoidiQ39236
KOiK03123
OMAiATAYYEF
OrthoDBi1589933at2759
PhylomeDBiQ39236

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q39236

Gene expression databases

ExpressionAtlasiQ39236 baseline and differential
GenevisibleiQ39236 AT

Family and domain databases

CDDicd10014 TFIIA_gamma_C, 1 hit
cd10145 TFIIA_gamma_N, 1 hit
Gene3Di1.10.287.190, 1 hit
2.30.18.10, 1 hit
InterProiView protein in InterPro
IPR009083 TFIIA_a-hlx
IPR009088 TFIIA_b-brl
IPR003194 TFIIA_gsu
IPR015871 TFIIA_gsu_C
IPR015872 TFIIA_gsu_N
PANTHERiPTHR10966 PTHR10966, 1 hit
PfamiView protein in Pfam
PF02751 TFIIA_gamma_C, 1 hit
PF02268 TFIIA_gamma_N, 1 hit
PIRSFiPIRSF009415 Hum_TFIIA_gamma, 1 hit
SUPFAMiSSF50784 SSF50784, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT2AG_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q39236
Secondary accession number(s): O49348
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2002
Last modified: September 18, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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