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Protein

Ferritin-1, chloroplastic

Gene

FER1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi105Iron 1PROSITE-ProRule annotation1
Metal bindingi140Iron 1PROSITE-ProRule annotation1
Metal bindingi140Iron 2PROSITE-ProRule annotation1
Metal bindingi143Iron 1PROSITE-ProRule annotation1
Metal bindingi189Iron 2PROSITE-ProRule annotation1
Metal bindingi223Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

  • ferric iron binding Source: InterPro
  • ferroxidase activity Source: UniProtKB-EC
  • iron ion binding Source: TAIR
  • protein domain specific binding Source: CAFA

GO - Biological processi

  • flower development Source: TAIR
  • intracellular sequestering of iron ion Source: GO_Central
  • iron ion homeostasis Source: TAIR
  • iron ion transport Source: TAIR
  • leaf development Source: TAIR
  • photosynthesis Source: TAIR
  • response to bacterium Source: TAIR
  • response to cold Source: TAIR
  • response to cytokinin Source: TAIR
  • response to hydrogen peroxide Source: TAIR
  • response to iron ion Source: TAIR
  • response to reactive oxygen species Source: TAIR
  • response to zinc ion Source: TAIR

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G01600-MONOMER
ReactomeiR-ATH-6798695 Neutrophil degranulation
R-ATH-917937 Iron uptake and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-1, chloroplastic1 Publication (EC:1.16.3.1Curated)
Short name:
AtFer11 Publication
Gene namesi
Name:FER11 Publication
Ordered Locus Names:At5g01600Imported
ORF Names:F7A7.120Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G01600
TAIRilocus:2149755 AT5G01600

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 48ChloroplastBy similarityAdd BLAST48
ChainiPRO_000000885449 – 255Ferritin-1, chloroplasticAdd BLAST207

Proteomic databases

PaxDbiQ39101
PRIDEiQ39101

PTM databases

iPTMnetiQ39101

Expressioni

Inductioni

Up-regulated by iron overload treatment, and by H2O2 (PubMed:11672431). Up-regulated by the phosphate starvation response transcription factor PHR1 (PubMed:23788639).2 Publications

Gene expression databases

ExpressionAtlasiQ39101 differential
GenevisibleiQ39101 AT

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).By similarity

GO - Molecular functioni

  • protein domain specific binding Source: CAFA

Protein-protein interaction databases

BioGridi16996, 8 interactors
STRINGi3702.AT5G01600.1

Structurei

3D structure databases

ProteinModelPortaliQ39101
SMRiQ39101
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 241Ferritin-like diironPROSITE-ProRule annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 87Extension peptide (EP)Add BLAST39

Sequence similaritiesi

Belongs to the ferritin family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2332 Eukaryota
COG1528 LUCA
HOGENOMiHOG000223383
InParanoidiQ39101
KOiK00522
OMAiECGLRAM
OrthoDBiEOG09360PX4
PhylomeDBiQ39101

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q39101-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNALSSFT AANPALSPKP LLPHGSASPS VSLGFSRKVG GGRAVVVAAA
60 70 80 90 100
TVDTNNMPMT GVVFQPFEEV KKADLAIPIT SHASLARQRF ADASEAVINE
110 120 130 140 150
QINVEYNVSY VYHSMYAYFD RDNVAMKGLA KFFKESSEEE RGHAEKFMEY
160 170 180 190 200
QNQRGGRVKL HPIVSPISEF EHAEKGDALY AMELALSLEK LTNEKLLNVH
210 220 230 240 250
KVASENNDPQ LADFVESEFL GEQIEAIKKI SDYITQLRMI GKGHGVWHFD

QMLLN
Length:255
Mass (Da):28,178
Last modified:November 1, 1996 - v1
Checksum:iC40E89CA4548FCB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42G → S in AAM61077 (Ref. 6) Curated1
Sequence conflicti67F → L in AAM61077 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94248 mRNA Translation: CAA63932.1
AF229850 Genomic DNA Translation: AAF73918.1
AL161946 Genomic DNA Translation: CAB82276.1
CP002688 Genomic DNA Translation: AED90364.1
AF326869 mRNA Translation: AAG41451.1
AF339691 mRNA Translation: AAK00373.1
AF412065 mRNA Translation: AAL06518.1
AY084509 mRNA Translation: AAM61077.1
PIRiS71880
RefSeqiNP_195780.1, NM_120238.4
UniGeneiAt.23533
At.73124
At.75488

Genome annotation databases

EnsemblPlantsiAT5G01600.1; AT5G01600.1; AT5G01600
GeneIDi831720
GrameneiAT5G01600.1; AT5G01600.1; AT5G01600
KEGGiath:AT5G01600

Similar proteinsi

Entry informationi

Entry nameiFRI1_ARATH
AccessioniPrimary (citable) accession number: Q39101
Secondary accession number(s): Q8LG19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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