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Protein

Acetaldehyde dehydrogenase 3

Gene

Bcep18194_B2960

Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei131Acyl-thioester intermediateUniRule annotation1
Binding sitei273NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi162 – 170NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciBLAT482957:G12V6-6371-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 3UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 3UniRule annotation
Gene namesi
Ordered Locus Names:Bcep18194_B2960
OrganismiBurkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876401 – 306Acetaldehyde dehydrogenase 3Add BLAST306

Structurei

3D structure databases

ProteinModelPortaliQ390P5
SMRiQ390P5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000052149
KOiK18366
OMAiIMMHNTI
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

Q390P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRKIRCALI GPGNIGTDLL AKLMRSPVLE PVWMVGIDPD SDGLKRAREL
60 70 80 90 100
GLKTTAEGVD GLLPHVQADA VQIAFDATSA YVHAENSRKL NALGVLMIDL
110 120 130 140 150
TPAAIGPYCV PPVNLMDHIG SGEMNVNMVT CGGQATIPMV RAVSRVQPVA
160 170 180 190 200
YGEIVATVSS RSVGPGTRKN IDEFTRTTAA AVAQVGGAKD GKAIIVINPA
210 220 230 240 250
DPPLIMRDTV HCLTETAPDE ARIVESVHAM IADVQRYVPG YRLVNGPVFD
260 270 280 290 300
GNRVSIYLEV EGLGDYLPKY AGNLDIMTAA AARTAEMFAE ELLAGRLALQ

PAAQAA
Length:306
Mass (Da):32,364
Last modified:November 22, 2005 - v1
Checksum:i854CD418D71933AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000152 Genomic DNA Translation: ABB13071.1
RefSeqiWP_011356550.1, NC_007511.1

Genome annotation databases

EnsemblBacteriaiABB13071; ABB13071; Bcep18194_B2960
KEGGibur:Bcep18194_B2960
PATRICifig|482957.22.peg.6782

Similar proteinsi

Entry informationi

Entry nameiACDH3_BURL3
AccessioniPrimary (citable) accession number: Q390P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 22, 2005
Last modified: February 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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