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Entry version 128 (05 Jun 2019)
Sequence version 2 (14 Aug 2001)
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Protein

Eukaryotic peptide chain release factor subunit 1-1

Gene

ERF1-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (PubMed:15474304). Modulates plant growth and development (PubMed:16113224).1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processGrowth regulation, Protein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic peptide chain release factor subunit 1-1
Short name:
Eukaryotic release factor 1-1
Short name:
eRF1-1
Alternative name(s):
Omnipotent suppressor protein 1 homolog 1
Short name:
SUP1 homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERF1-1
Ordered Locus Names:At5g47880
ORF Names:MCA23.22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT5G47880

The Arabidopsis Information Resource

More...
TAIRi
locus:2160972 AT5G47880

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi182G → A: Loss of peptidyl-tRNA hydrolytic activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001431621 – 436Eukaryotic peptide chain release factor subunit 1-1Add BLAST436

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q39097

PRoteomics IDEntifications database

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PRIDEi
Q39097

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q39097

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q39097 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q39097 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of two subunits, one of which binds GTP.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G47880.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q39097

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic release factor 1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0688 Eukaryota
COG1503 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000224681

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q39097

KEGG Orthology (KO)

More...
KOi
K03265

Identification of Orthologs from Complete Genome Data

More...
OMAi
SVKHFNK

Database of Orthologous Groups

More...
OrthoDBi
592406at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q39097

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1330.30, 1 hit
3.30.420.60, 1 hit
3.30.960.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042226 eFR1_2_sf
IPR005140 eRF1_1_Pelota
IPR005141 eRF1_2
IPR005142 eRF1_3
IPR029064 L30e-like
IPR004403 Peptide_chain-rel_eRF1/aRF1
IPR024049 Release_factor_eRF1/aRF1_N

The PANTHER Classification System

More...
PANTHERi
PTHR10113 PTHR10113, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03463 eRF1_1, 1 hit
PF03464 eRF1_2, 1 hit
PF03465 eRF1_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01194 eRF1_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55315 SSF55315, 1 hit
SSF55481 SSF55481, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03676 aRF1/eRF1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q39097-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDKNDDDKN IEIWKIKKLI KSLEAARGNG TSMISLIMPP RDQVSRVTKM
60 70 80 90 100
LGDEYGTASN IKSRVNRQSV LGAITSAQQR LKLYNRVPPN GLVLYTGTIV
110 120 130 140 150
NEDGKEKKVT IDFEPFRPIN ASLYLCDNKF HTEALNELLE SDDKFGFIVM
160 170 180 190 200
DGNGTLFGTL SGNTREVLHK FSVDLPKKHG RGGQSALRFA RLRMEKRHNY
210 220 230 240 250
VRKTAELATQ YYINPATSQP NVSGLILAGS ADFKTELSQS DMFDPRLAAK
260 270 280 290 300
ILNVVDVSYG GENGFNQAIE LSAEILANVK FIQEKRLIGK YFEEISQDTG
310 320 330 340 350
KYVFGVEDTL NALESGAIET LIVWENLDIN RYVMKNSATG ETVIKHLNKE
360 370 380 390 400
QEANTENFKV ADSDLALDVE EKLSLLEWLA NEYRRFGCAL EFVTNKSQEG
410 420 430
SQFCRGFGGI GGILRYQLDM TAFDSEDGEA LDDDSE
Length:436
Mass (Da):48,723
Last modified:August 14, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE77630B26FA2E8AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti121A → G in AAA91169 (Ref. 1) Curated1
Sequence conflicti156L → P in AAK91475 (PubMed:14593172).1
Sequence conflicti156L → P in AAN28907 (PubMed:14593172).1
Sequence conflicti192L → F in BAH19602 (PubMed:19423640).1
Sequence conflicti197R → S in BAH19602 (PubMed:19423640).1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U40217 mRNA Translation: AAA91169.1
AB016886 Genomic DNA Translation: BAB11335.1
CP002688 Genomic DNA Translation: AED95583.1
CP002688 Genomic DNA Translation: AED95584.1
AY050462 mRNA Translation: AAK91475.1
AY143968 mRNA Translation: AAN28907.1
AK316895 mRNA Translation: BAH19602.1

NCBI Reference Sequences

More...
RefSeqi
NP_001032029.1, NM_001036952.1
NP_199599.1, NM_124162.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G47880.1; AT5G47880.1; AT5G47880
AT5G47880.2; AT5G47880.2; AT5G47880

Database of genes from NCBI RefSeq genomes

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GeneIDi
834839

Gramene; a comparative resource for plants

More...
Gramenei
AT5G47880.1; AT5G47880.1; AT5G47880
AT5G47880.2; AT5G47880.2; AT5G47880

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G47880

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40217 mRNA Translation: AAA91169.1
AB016886 Genomic DNA Translation: BAB11335.1
CP002688 Genomic DNA Translation: AED95583.1
CP002688 Genomic DNA Translation: AED95584.1
AY050462 mRNA Translation: AAK91475.1
AY143968 mRNA Translation: AAN28907.1
AK316895 mRNA Translation: BAH19602.1
RefSeqiNP_001032029.1, NM_001036952.1
NP_199599.1, NM_124162.4

3D structure databases

SMRiQ39097
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G47880.2

PTM databases

iPTMnetiQ39097

Proteomic databases

PaxDbiQ39097
PRIDEiQ39097

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G47880.1; AT5G47880.1; AT5G47880
AT5G47880.2; AT5G47880.2; AT5G47880
GeneIDi834839
GrameneiAT5G47880.1; AT5G47880.1; AT5G47880
AT5G47880.2; AT5G47880.2; AT5G47880
KEGGiath:AT5G47880

Organism-specific databases

AraportiAT5G47880
TAIRilocus:2160972 AT5G47880

Phylogenomic databases

eggNOGiKOG0688 Eukaryota
COG1503 LUCA
HOGENOMiHOG000224681
InParanoidiQ39097
KOiK03265
OMAiSVKHFNK
OrthoDBi592406at2759
PhylomeDBiQ39097

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q39097

Gene expression databases

ExpressionAtlasiQ39097 baseline and differential
GenevisibleiQ39097 AT

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
3.30.420.60, 1 hit
3.30.960.10, 1 hit
InterProiView protein in InterPro
IPR042226 eFR1_2_sf
IPR005140 eRF1_1_Pelota
IPR005141 eRF1_2
IPR005142 eRF1_3
IPR029064 L30e-like
IPR004403 Peptide_chain-rel_eRF1/aRF1
IPR024049 Release_factor_eRF1/aRF1_N
PANTHERiPTHR10113 PTHR10113, 1 hit
PfamiView protein in Pfam
PF03463 eRF1_1, 1 hit
PF03464 eRF1_2, 1 hit
PF03465 eRF1_3, 1 hit
SMARTiView protein in SMART
SM01194 eRF1_1, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit
SSF55481 SSF55481, 1 hit
TIGRFAMsiTIGR03676 aRF1/eRF1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERF1X_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q39097
Secondary accession number(s): B9DFT5, Q94A12, Q9FIJ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: June 5, 2019
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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