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Protein

Casein kinase 1-like protein 11

Gene

CKL11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate casein, phosvitin, myosin light chains and poly(Glu,Tyr) in vitro.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.Curated

Activity regulationi

Partially inhibited by N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide (CKI-7).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44ATPPROSITE-ProRule annotation1
Active sitei134Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 29ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: TAIR

GO - Biological processi

  • phosphorylation Source: TAIR
  • protein autophosphorylation Source: TAIR

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase 1-like protein 11Curated (EC:2.7.11.11 Publication)
Alternative name(s):
Protein CASEIN KINASE I-LIKE 111 Publication
Gene namesi
Name:CKL111 Publication
Synonyms:CKI11 Publication
Ordered Locus Names:At4g14340Imported
ORF Names:dl3210cImported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G14340
TAIRilocus:2129640 AT4G14340

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004371501 – 457Casein kinase 1-like protein 11Add BLAST457

Post-translational modificationi

Autophosphorylated.By similarity

Proteomic databases

PaxDbiQ39050
PRIDEiQ39050

PTM databases

iPTMnetiQ39050

Expressioni

Gene expression databases

ExpressionAtlasiQ39050 baseline and differential

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ39050, 8 interactors
STRINGi3702.AT4G14340.1

Structurei

3D structure databases

ProteinModelPortaliQ39050
SMRiQ39050
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 284Protein kinasePROSITE-ProRule annotationAdd BLAST270

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi354 – 416Ser-richPROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1164 Eukaryota
ENOG410XPGP LUCA
HOGENOMiHOG000182055
OMAiPYREDKH
OrthoDBiEOG09360AD1
PhylomeDBiQ39050

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q39050-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRNQKMDHV IGGKFKLGRK LGSGSFGELY LGINIQTGEE VAVKLEPVKT
60 70 80 90 100
RHPQLQYESK IYMFLQGGTG VPHLKWFGVE GEYSCMVIDL LGPSLEDLFN
110 120 130 140 150
YCKRIFSLKS VLMLADQLIC RVEYMHSRGF LHRDIKPDNF LMGLGRRANQ
160 170 180 190 200
VYIIDYGLAK KYKDLQTQKH IPYRENKNLT GTARYASVNT HLGIEQSRRD
210 220 230 240 250
DLESLGYVLM YFLRGSLPWQ GLKAGTKKQK YDKISEKKML TSVETLCKSY
260 270 280 290 300
PSEFTSYFHY CRSLRFEDKP DYSYLRRLFR DLFIREGYQL DYVFDWTISK
310 320 330 340 350
YPQIGSSSRP RPTPRPALDP PGPPAERAEK PTVGQDLRGR FTGAIEAFTR
360 370 380 390 400
RNVSSQGALG DRSRHRSSDD IPSSAKEVHE SRNGSTSKRG VISSTRPGSS
410 420 430 440 450
AEPSENHSSR LFSSGSRHAT TQRVPQSYES AAAARPGHED AIRNFELLTI

GSGKKRK
Length:457
Mass (Da):51,953
Last modified:November 1, 1996 - v1
Checksum:iBBA8FC844701F946
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78818 mRNA Translation: CAA55395.1
AF250343 mRNA Translation: AAG10149.1
AY943850 mRNA Translation: AAY24540.1
Z97336 Genomic DNA Translation: CAB10213.1
AL161538 Genomic DNA Translation: CAB78476.1
CP002687 Genomic DNA Translation: AEE83421.1
AY052364 mRNA Translation: AAK96555.1
AY060528 mRNA Translation: AAL31141.1
PIRiC71405
RefSeqiNP_193170.1, NM_117511.5
UniGeneiAt.12

Genome annotation databases

EnsemblPlantsiAT4G14340.1; AT4G14340.1; AT4G14340
GeneIDi827076
GrameneiAT4G14340.1; AT4G14340.1; AT4G14340
KEGGiath:AT4G14340

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78818 mRNA Translation: CAA55395.1
AF250343 mRNA Translation: AAG10149.1
AY943850 mRNA Translation: AAY24540.1
Z97336 Genomic DNA Translation: CAB10213.1
AL161538 Genomic DNA Translation: CAB78476.1
CP002687 Genomic DNA Translation: AEE83421.1
AY052364 mRNA Translation: AAK96555.1
AY060528 mRNA Translation: AAL31141.1
PIRiC71405
RefSeqiNP_193170.1, NM_117511.5
UniGeneiAt.12

3D structure databases

ProteinModelPortaliQ39050
SMRiQ39050
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ39050, 8 interactors
STRINGi3702.AT4G14340.1

PTM databases

iPTMnetiQ39050

Proteomic databases

PaxDbiQ39050
PRIDEiQ39050

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G14340.1; AT4G14340.1; AT4G14340
GeneIDi827076
GrameneiAT4G14340.1; AT4G14340.1; AT4G14340
KEGGiath:AT4G14340

Organism-specific databases

AraportiAT4G14340
TAIRilocus:2129640 AT4G14340

Phylogenomic databases

eggNOGiKOG1164 Eukaryota
ENOG410XPGP LUCA
HOGENOMiHOG000182055
OMAiPYREDKH
OrthoDBiEOG09360AD1
PhylomeDBiQ39050

Miscellaneous databases

PROiPR:Q39050

Gene expression databases

ExpressionAtlasiQ39050 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCKL11_ARATH
AccessioniPrimary (citable) accession number: Q39050
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2016
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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