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Entry version 178 (16 Oct 2019)
Sequence version 2 (10 May 2004)
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Protein

Shaggy-related protein kinase eta

Gene

ASK7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator in brassinosteroid signal transduction pathway important for plant growth. May be also involved in auxin signaling pathway. Phosphorylates and increases the degradation of BZR1 and BZR2/BES1 by the proteasome. Phosphorylates BHLH150, beet curly top virus C4 and tomato golden mosaic virus AC4 on threonine and serine residues. Upon brassinosteroid signaling, inhibits stomatal development by phosphorylating and inhibiting the MAPKK kinase YDA and the MAPK kinases MKK4 and MKK5 (PubMed:11847343, PubMed:12114546, PubMed:12427989, PubMed:17280695, PubMed:22307275, PubMed:23341468). Phosphorylates BSK1, BSK3, BSK5, BSK6, BSK8 AND BSK11 in vitro (PubMed:23496207). Phoyphorylates and destabilizes WRKY46, WRKY54 and WRKY70 (PubMed:28576847). Mediates BASL nuclear exclusion; kinase activity is required for this function (PubMed:30429609). Required first at the cortical polarity site, to restrict MAPK signaling and promote asymmetric cell division (ACD), and second in the nucleus of stomatal lineage ground cells (SLGCs) or meristemoids, to limit cell division and to promote differentiation into pavement or stomatal guard cells, respectively, likely by initiating BASL polarization (PubMed:30429609). Phosphorylates BASL, YDA and SPCH in vitro and POLAR in vivo (PubMed:30429609). Phosphorylates and inhibits SPCH in the nucleus of SLGC undergoing ACD, thus negatively regulating stomatal development (PubMed:30429609, PubMed:22466366).10 Publications

Miscellaneous

Unlike other GSK3 kinases, does not require a priming phosphorylation event or the presence of a scaffold protein to phosphorylate its substrates.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inactivated by an unknown mechanism after binding of brassinosteroids to the brassinosteroid receptor complex (Probable). Inhibited by lithium. Inhibited by dephosphorylation at Tyr-200 by BSU1 (PubMed:21855796). Competitive inhibition by KIB1 that reduces substrate (e.g. BZR1) access (PubMed:28575660). Repressed by bikinin (PubMed:22466366).Curated3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei69ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei165Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi46 – 54ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processBrassinosteroid signaling pathway, Host-virus interaction
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.26 399

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Shaggy-related protein kinase eta1 Publication (EC:2.7.11.13 Publications)
Alternative name(s):
ASK-eta1 Publication
Protein BRASSINOSTEROID INSENSITIVE 21 Publication
Protein ULTRACURVATA 11 Publication
Shaggy-related protein kinase 211 Publication
Short name:
AtSK211 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASK71 Publication
Synonyms:BIN21 Publication, DWF121 Publication, SK211 Publication, UCU11 Publication
Ordered Locus Names:At4g18710Imported
ORF Names:F28A21.120Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G18710

The Arabidopsis Information Resource

More...
TAIRi
locus:2124082 AT4G18710

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Increased stability of SPCH and formation of excessive stomatal and non-stomatal cell.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi69K → R: Abolishes kinase activity. Altered BASL exclusion from nucleus. 3 Publications1
Mutagenesisi80R → A: No effect. 1 Publication1
Mutagenesisi200Y → F: Normal interaction with KIB1. 1 Publication1
Mutagenesisi261T → I in bin2-2; brassinosteroid-insensitive dwarf mutant; increased kinase activity. 1 Publication1
Mutagenesisi263E → K in dwf12-2D/bin2-1; brassinosteroid-insensitive dwarf mutant; increased kinase activity. Reduced interaction with KIB1. Strongly reduced number of stomata in hypocotyls as well as decreased stomatal index in leaves. 4 Publications1
Mutagenesisi264E → K in dwf12-1D/ucu1-1/ucu1-2; brassinosteroid-insensitive dwarf mutant. 2 Publications1
Mutagenesisi284P → S in ucu1-3; leaves rolled spirally downward. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000862221 – 380Shaggy-related protein kinase etaAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei104PhosphothreonineSequence analysis1
Modified residuei105PhosphoserineSequence analysis1
Modified residuei187PhosphoserineSequence analysis1
Modified residuei200Phosphotyrosine1 Publication1
Modified residuei220PhosphothreonineSequence analysis1
Modified residuei261PhosphothreonineSequence analysis1
Modified residuei310PhosphoserineSequence analysis1
Modified residuei314PhosphothreonineSequence analysis1
Modified residuei353PhosphoserineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated mainly on threonine and serine residues.2 Publications
Ubiquitination and subsequent proteasomal degradation mediated by KIB1.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q39011

PRoteomics IDEntifications database

More...
PRIDEi
Q39011

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q39011

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the two outer cell layers of the developing seed coat and restricted to the suspensor cells in developing embryos (PubMed:10080716). Mostly expressed in stomatal lineage cells with asymmetric cell division (ACD) potential (PubMed:30429609). Observed in small cells of non-protruding hypocotyl cell files and of developing cotyledon epidermis (PubMed:22466366).3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected throughout the epidermis in young seedlings, and accumulates progressively during epidermal cell maturation, especially in stomatal lineage cells with asymmetric cell division (ACD) potential.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q39011 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q39011 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts in vitro with the C-terminal fragment of BZR1 and with BES1/BZR2, but not through the kinase domain.

Interacts with BHLH150, beet curly top virus AL4/C4 and tomato golden mosaic virus AL4/AC4.

Interacts with YDA.

Interacts with MKK4.

Interacts with KIB1 and KIB2 in a brassinosteroid (BR)-dependent manner (PubMed:28575660).

Interacts with BSK1, BSK6, BSK8 and BSK11 (PubMed:23496207). Binds to WRKY46, WRKY54 and WRKY70 (PubMed:28576847).

Component of a complex made of POLAR, BASL, ASK7/BIN2 and ASK3/SK12 (PubMed:30429609). Binds to POLAR and BASL (PubMed:30429609).

10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
12898, 30 interactors

Database of interacting proteins

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DIPi
DIP-46010N

Protein interaction database and analysis system

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IntActi
Q39011, 10 interactors

Molecular INTeraction database

More...
MINTi
Q39011

STRING: functional protein association networks

More...
STRINGi
3702.AT4G18710.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q39011

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 324Protein kinasePROSITE-ProRule annotationAdd BLAST285

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0658 Eukaryota
COG0515 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233017

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q39011

KEGG Orthology (KO)

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KOi
K14502

Identification of Orthologs from Complete Genome Data

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OMAi
NERITAY

Database of Orthologous Groups

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OrthoDBi
990896at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q39011

Family and domain databases

Conserved Domains Database

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CDDi
cd14137 STKc_GSK3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR039192 STKc_GSK3

Pfam protein domain database

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Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. According to EST sequences.

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q39011-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADDKEMPAA VVDGHDQVTG HIISTTIGGK NGEPKQTISY MAERVVGTGS
60 70 80 90 100
FGIVFQAKCL ETGETVAIKK VLQDRRYKNR ELQLMRVMDH PNVVCLKHCF
110 120 130 140 150
FSTTSKDELF LNLVMEYVPE SLYRVLKHYS SANQRMPLVY VKLYMYQIFR
160 170 180 190 200
GLAYIHNVAG VCHRDLKPQN LLVDPLTHQV KICDFGSAKQ LVKGEANISY
210 220 230 240 250
ICSRFYRAPE LIFGATEYTT SIDIWSAGCV LAELLLGQPL FPGENAVDQL
260 270 280 290 300
VEIIKVLGTP TREEIRCMNP HYTDFRFPQI KAHPWHKIFH KRMPPEAIDF
310 320 330 340 350
ASRLLQYSPS LRCTALEACA HPFFDELREP NARLPNGRPF PPLFNFKQEV
360 370 380
AGSSPELVNK LIPDHIKRQL GLSFLNQSGT
Length:380
Mass (Da):43,099
Last modified:May 10, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86C2FD5F77201168
GO
Isoform 2 (identifier: Q39011-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.

Show »
Length:374
Mass (Da):42,409
Checksum:i4D7785FB1A9561A5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4JRM5F4JRM5_ARATH
Protein kinase superfamily protein
BIN2 ATSK21, BRASSINOSTEROID-INSENSITIVE 2, DWARF 12, DWF12, SHAGGY-LIKE KINASE 21
274Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti105S → E in CAA64409 (Ref. 1) Curated1
Sequence conflicti105S → E in CAA70144 (PubMed:9611268).Curated1
Sequence conflicti121S → T in CAA64409 (Ref. 1) Curated1
Sequence conflicti121S → T in CAA70144 (PubMed:9611268).Curated1
Sequence conflicti145M → S in CAA64409 (Ref. 1) Curated1
Sequence conflicti145M → S in CAA70144 (PubMed:9611268).Curated1
Sequence conflicti157 – 159NVA → SCP in CAA64409 (Ref. 1) Curated3
Sequence conflicti157 – 159NVA → SCP in CAA70144 (PubMed:9611268).Curated3
Sequence conflicti196A → P in CAA64409 (Ref. 1) Curated1
Sequence conflicti196A → P in CAA70144 (PubMed:9611268).Curated1
Sequence conflicti271H → N in CAA64409 (Ref. 1) Curated1
Sequence conflicti271H → N in CAA70144 (PubMed:9611268).Curated1
Sequence conflicti276R → K in CAA64409 (Ref. 1) Curated1
Sequence conflicti276R → K in CAA70144 (PubMed:9611268).Curated1
Sequence conflicti298 – 300IDF → VDL in CAA64409 (Ref. 1) Curated3
Sequence conflicti298 – 300IDF → VDL in CAA70144 (PubMed:9611268).Curated3
Sequence conflicti327L → H in AAL77705 (PubMed:14593172).Curated1
Sequence conflicti340F → L in CAA64409 (Ref. 1) Curated1
Sequence conflicti340F → L in CAA70144 (PubMed:9611268).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0600651 – 6Missing in isoform 2. 6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X94939 mRNA Translation: CAA64409.1
Y08947 Genomic DNA Translation: CAA70144.1
AY157149 Genomic DNA Translation: AAN71719.1
AL035526 Genomic DNA Translation: CAB37456.1
AL161549 Genomic DNA Translation: CAB78873.1
CP002687 Genomic DNA Translation: AEE84079.1
AY075699 mRNA Translation: AAL77705.1
BT026031 mRNA Translation: ABG48387.1
AY086529 mRNA Translation: AAM63594.1
AK318990 mRNA Translation: BAH57105.1
AK317697 mRNA Translation: BAH20356.1

Protein sequence database of the Protein Information Resource

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PIRi
T04863

NCBI Reference Sequences

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RefSeqi
NP_193606.1, NM_117987.4 [Q39011-1]

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT4G18710.1; AT4G18710.1; AT4G18710 [Q39011-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
827605

Gramene; a comparative resource for plants

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Gramenei
AT4G18710.1; AT4G18710.1; AT4G18710 [Q39011-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT4G18710

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94939 mRNA Translation: CAA64409.1
Y08947 Genomic DNA Translation: CAA70144.1
AY157149 Genomic DNA Translation: AAN71719.1
AL035526 Genomic DNA Translation: CAB37456.1
AL161549 Genomic DNA Translation: CAB78873.1
CP002687 Genomic DNA Translation: AEE84079.1
AY075699 mRNA Translation: AAL77705.1
BT026031 mRNA Translation: ABG48387.1
AY086529 mRNA Translation: AAM63594.1
AK318990 mRNA Translation: BAH57105.1
AK317697 mRNA Translation: BAH20356.1
PIRiT04863
RefSeqiNP_193606.1, NM_117987.4 [Q39011-1]

3D structure databases

SMRiQ39011
ModBaseiSearch...

Protein-protein interaction databases

BioGridi12898, 30 interactors
DIPiDIP-46010N
IntActiQ39011, 10 interactors
MINTiQ39011
STRINGi3702.AT4G18710.1

PTM databases

iPTMnetiQ39011

Proteomic databases

PaxDbiQ39011
PRIDEiQ39011

Genome annotation databases

EnsemblPlantsiAT4G18710.1; AT4G18710.1; AT4G18710 [Q39011-1]
GeneIDi827605
GrameneiAT4G18710.1; AT4G18710.1; AT4G18710 [Q39011-1]
KEGGiath:AT4G18710

Organism-specific databases

AraportiAT4G18710
TAIRilocus:2124082 AT4G18710

Phylogenomic databases

eggNOGiKOG0658 Eukaryota
COG0515 LUCA
HOGENOMiHOG000233017
InParanoidiQ39011
KOiK14502
OMAiNERITAY
OrthoDBi990896at2759
PhylomeDBiQ39011

Enzyme and pathway databases

BRENDAi2.7.11.26 399

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q39011

Gene expression databases

ExpressionAtlasiQ39011 baseline and differential
GenevisibleiQ39011 AT

Family and domain databases

CDDicd14137 STKc_GSK3, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR039192 STKc_GSK3
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKSG7_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q39011
Secondary accession number(s): B9DHY9
, C0Z326, Q147R2, Q8S9H8, Q9SN42
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2004
Last modified: October 16, 2019
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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