Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Meiotic recombination protein DMC1 homolog

Gene

DMC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (PubMed:10488231, PubMed:23300481). Mediates interhomolog recombination during meiosis (PubMed:17785529).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei235ssDNA or dsDNABy similarity1
Binding sitei238ssDNABy similarity1
Binding sitei241ssDNA or dsDNABy similarity1
Binding sitei247ssDNA or dsDNABy similarity1
Binding sitei315ssDNABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi133 – 140ATPCurated8

GO - Molecular functioni

GO - Biological processi

  • chiasma assembly Source: TAIR
  • DNA metabolic process Source: TAIR
  • DNA recombinase assembly Source: GO_Central
  • meiotic cell cycle Source: TAIR
  • mitotic recombination Source: GO_Central
  • response to ionizing radiation Source: GO_Central
  • strand invasion Source: GO_Central

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Meiosis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Meiotic recombination protein DMC1 homologCurated
Short name:
AtDMC11 Publication
Gene namesi
Name:DMC11 Publication
Synonyms:LIM15
Ordered Locus Names:At3g22880
ORF Names:F5N5.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G22880
TAIRilocus:2084558 AT3G22880

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Strongly reduced fertility and seed numbers due to defects in male and female gametogenesis.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001229201 – 344Meiotic recombination protein DMC1 homologAdd BLAST344

Proteomic databases

PaxDbiQ39009
PRIDEiQ39009

Expressioni

Tissue specificityi

Expressed in mitotic and/or meiotic tissues. Expressed in roots, leaves and anthers and carpels of young fower buds.1 Publication

Developmental stagei

Cell cycle regulated, peaking at the S phase. It is also expressed at high levels in exponentially growing cells in suspension cultures.1 Publication

Gene expression databases

ExpressionAtlasiQ39009 baseline and differential
GenevisibleiQ39009 AT

Interactioni

Subunit structurei

Double stacked ring-shaped homooctamer (By similarity). Interacts with BRCA2A and BRCA2B (PubMed:16415210).By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi7192, 6 interactors
IntActiQ39009, 7 interactors
STRINGi3702.AT3G22880.1

Structurei

3D structure databases

ProteinModelPortaliQ39009
SMRiQ39009
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecA family. DMC1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1434 Eukaryota
COG0468 LUCA
HOGENOMiHOG000227426
KOiK10872
OMAiCTVKGIQ
OrthoDBiEOG09360F79
PhylomeDBiQ39009

Family and domain databases

CDDicd01123 Rad51_DMC1_radA, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011940 DMC1_rcmbase
IPR013632 DNA_recomb/repair_Rad51_C
IPR016467 DNA_recomb/repair_RecA-like
IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
IPR020587 RecA_monomer-monomer_interface
PfamiView protein in Pfam
PF08423 Rad51, 1 hit
PIRSFiPIRSF005856 Rad51, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF47794 SSF47794, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02238 recomb_DMC1, 1 hit
PROSITEiView protein in PROSITE
PS50162 RECA_2, 1 hit
PS50163 RECA_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q39009-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMASLKAEET SQMQLVEREE NDEDEDLFEM IDKLIAQGIN AGDVKKLQEA
60 70 80 90 100
GIHTCNGLMM HTKKNLTGIK GLSEAKVDKI CEAAEKIVNF GYMTGSDALI
110 120 130 140 150
KRKSVVKITT GCQALDDLLG GGIETSAITE AFGEFRSGKT QLAHTLCVTT
160 170 180 190 200
QLPTNMKGGN GKVAYIDTEG TFRPDRIVPI AERFGMDPGA VLDNIIYARA
210 220 230 240 250
YTYEHQYNLL LGLAAKMSEE PFRILIVDSI IALFRVDFTG RGELADRQQK
260 270 280 290 300
LAQMLSRLIK IAEEFNVAVY MTNQVIADPG GGMFISDPKK PAGGHVLAHA
310 320 330 340
ATIRLLFRKG KGDTRVCKVY DAPNLAEAEA SFQITQGGIA DAKD
Length:344
Mass (Da):37,513
Last modified:July 11, 2002 - v2
Checksum:iE0A97D320A41387D
GO

Sequence cautioni

The sequence BAA08255 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB03033 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104S → L in BAA08255 (PubMed:7584052).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45415 Genomic DNA Translation: BAA08255.1 Sequence problems.
U76670 Genomic DNA Translation: AAC49617.1
AP001300 Genomic DNA Translation: BAB03033.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE76687.1
BT023447 mRNA Translation: AAY56438.1
PIRiJC4092
RefSeqiNP_188928.2, NM_113188.3
UniGeneiAt.50216

Genome annotation databases

EnsemblPlantsiAT3G22880.1; AT3G22880.1; AT3G22880
GeneIDi821860
GrameneiAT3G22880.1; AT3G22880.1; AT3G22880
KEGGiath:AT3G22880

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45415 Genomic DNA Translation: BAA08255.1 Sequence problems.
U76670 Genomic DNA Translation: AAC49617.1
AP001300 Genomic DNA Translation: BAB03033.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE76687.1
BT023447 mRNA Translation: AAY56438.1
PIRiJC4092
RefSeqiNP_188928.2, NM_113188.3
UniGeneiAt.50216

3D structure databases

ProteinModelPortaliQ39009
SMRiQ39009
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi7192, 6 interactors
IntActiQ39009, 7 interactors
STRINGi3702.AT3G22880.1

Proteomic databases

PaxDbiQ39009
PRIDEiQ39009

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G22880.1; AT3G22880.1; AT3G22880
GeneIDi821860
GrameneiAT3G22880.1; AT3G22880.1; AT3G22880
KEGGiath:AT3G22880

Organism-specific databases

AraportiAT3G22880
TAIRilocus:2084558 AT3G22880

Phylogenomic databases

eggNOGiKOG1434 Eukaryota
COG0468 LUCA
HOGENOMiHOG000227426
KOiK10872
OMAiCTVKGIQ
OrthoDBiEOG09360F79
PhylomeDBiQ39009

Miscellaneous databases

PROiPR:Q39009

Gene expression databases

ExpressionAtlasiQ39009 baseline and differential
GenevisibleiQ39009 AT

Family and domain databases

CDDicd01123 Rad51_DMC1_radA, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011940 DMC1_rcmbase
IPR013632 DNA_recomb/repair_Rad51_C
IPR016467 DNA_recomb/repair_RecA-like
IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
IPR020587 RecA_monomer-monomer_interface
PfamiView protein in Pfam
PF08423 Rad51, 1 hit
PIRSFiPIRSF005856 Rad51, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF47794 SSF47794, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02238 recomb_DMC1, 1 hit
PROSITEiView protein in PROSITE
PS50162 RECA_2, 1 hit
PS50163 RECA_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDMC1_ARATH
AccessioniPrimary (citable) accession number: Q39009
Secondary accession number(s): P93001, Q4V3A9, Q9LIL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 11, 2002
Last modified: September 12, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again