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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotationSAAS annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 2 (folE2-2), GTP cyclohydrolase 1 (folE), GTP cyclohydrolase (WI95_31440), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase 1 (folE), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 1 (folE2-1), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi92ZincUniRule annotation1
Metal bindingi95ZincUniRule annotation1
Metal bindingi163ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processOne-carbon metabolismUniRule annotationSAAS annotation
LigandGTP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Short name:
GTP-CH-IUniRule annotation
Gene namesi
Name:folEUniRule annotation
Ordered Locus Names:Bcep18194_B3132Imported
OrganismiBurkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)Imported
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002705 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Homopolymer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ38ZX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 199GTP_cyclohydroIInterPro annotationAdd BLAST178

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000221222
KOiK01495
OMAiIVVVECE
OrthoDBiPOG091H01SE

Family and domain databases

HAMAPiMF_00223 FolE, 1 hit
InterProiView protein in InterPro
IPR001474 GTP_CycHdrlase_I
IPR018234 GTP_CycHdrlase_I_CS
IPR020602 GTP_CycHdrlase_I_dom
PANTHERiPTHR11109 PTHR11109, 1 hit
PfamiView protein in Pfam
PF01227 GTP_cyclohydroI, 1 hit
TIGRFAMsiTIGR00063 folE, 1 hit
PROSITEiView protein in PROSITE
PS00859 GTP_CYCLOHYDROL_1_1, 1 hit
PS00860 GTP_CYCLOHYDROL_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q38ZX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKKSARPE PAASRPSREE AEDAVRVLLR WAGDDPAREG LIDTPARVVR
60 70 80 90 100
AYEQFFAGYA LEPRDILART FSEVDGYDEM IVLKDIRFES YCEHHMVPII
110 120 130 140 150
GRAHVAYLPN HRVVGISKLA RLVDAFAKRL QIQEKMTVQI ADTLFDVLQP
160 170 180 190 200
KGVGVILEAA HQCISTRGVH KPGVEMVTSR MLGTFRTDPS TRREFLSIVA
210
NPSSVNLTNT
Length:210
Mass (Da):23,485
Last modified:November 22, 2005 - v1
Checksum:i8A24E2EE1F68ED4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000152 Genomic DNA Translation: ABB13242.1
RefSeqiWP_011356720.1, NC_007511.1

Genome annotation databases

EnsemblBacteriaiABB13242; ABB13242; Bcep18194_B3132
KEGGibur:Bcep18194_B3132
PATRICifig|482957.22.peg.6962

Similar proteinsi

Entry informationi

Entry nameiQ38ZX4_BURL3
AccessioniPrimary (citable) accession number: Q38ZX4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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