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UniProtKB - Q38SD2 (LRRK1_HUMAN)

Entry version 150 (17 Jun 2020)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
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Protein

Leucine-rich repeat serine/threonine-protein kinase 1

Gene

LRRK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Binding of GTP stimulates kinase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1270ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1386Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1248 – 1256ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, GTP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q38SD2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat serine/threonine-protein kinase 1 (EC:2.7.11.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRK1Imported
Synonyms:KIAA1790Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000154237.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:18608 LRRK1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610986 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q38SD2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi651K → A: Loss of GTP/GDP-binding. 1 Publication1
Mutagenesisi746K → G: No effect on GTP-binding but reduction in subsequent stimulation of kinase activity. 1 Publication1
Mutagenesisi1022F → C: No effect on GTP-binding but loss of subsequent stimulation of kinase activity. 1 Publication1
Mutagenesisi1270K → W: Loss of autophosphorylation. 1 Publication1
Mutagenesisi1412I → T: No effect on GTP-binding but reduction in subsequent stimulation of kinase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		79705

MalaCards human disease database

More...MalaCardsi		LRRK1

Open Targets

More...OpenTargetsi		ENSG00000154237

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		500548 Osteosclerotic metaphyseal dysplasia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134892363

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q38SD2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LRRK1

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104220

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002333771 – 2015Leucine-rich repeat serine/threonine-protein kinase 1Add BLAST2015

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q38SD2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q38SD2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q38SD2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q38SD2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q38SD2

PeptideAtlas

More...PeptideAtlasi		Q38SD2

PRoteomics IDEntifications database

More...PRIDEi		Q38SD2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61644 [Q38SD2-1]
61645 [Q38SD2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q38SD2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q38SD2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000154237 Expressed in lymph node and 168 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q38SD2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q38SD2 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000154237 Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122823, 86 interactors

Database of interacting proteins

More...DIPi		DIP-50235N

Protein interaction database and analysis system

More...IntActi		Q38SD2, 81 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000373600

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q38SD2 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati86 – 116ANK 1Add BLAST31
Repeati119 – 148ANK 2Add BLAST30
Repeati152 – 182ANK 3Add BLAST31
Repeati193 – 222ANK 4Add BLAST30
Repeati279 – 300LRR 1Add BLAST22
Repeati303 – 324LRR 2Add BLAST22
Repeati330 – 351LRR 3Add BLAST22
Repeati353 – 374LRR 4Add BLAST22
Repeati381 – 402LRR 5Add BLAST22
Repeati405 – 426LRR 6Add BLAST22
Repeati427 – 447LRR 7Add BLAST21
Repeati451 – 472LRR 8Add BLAST22
Repeati474 – 495LRR 9Add BLAST22
Repeati498 – 519LRR 10Add BLAST22
Repeati549 – 570LRR 11Add BLAST22
Repeati572 – 594LRR 12Add BLAST23
Repeati596 – 617LRR 13Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini632 – 826RocPROSITE-ProRule annotationAdd BLAST195
Domaini1242 – 1525Protein kinasePROSITE-ProRule annotationAdd BLAST284

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.Curated

Keywords - Domaini

ANK repeat, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0192 Eukaryota
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160363

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001731_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q38SD2

KEGG Orthology (KO)

More...KOi		K08843

Identification of Orthologs from Complete Genome Data

More...OMAi		VPCHICA

Database of Orthologous Groups

More...OrthoDBi		14978at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q38SD2

TreeFam database of animal gene trees

More...TreeFami		TF313679

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR032171 COR
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR027417 P-loop_NTPase
IPR000719 Prot_kinase_dom
IPR020859 ROC_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796 Ank_2, 1 hit
PF16095 COR, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248 ANK, 3 hits
SM00369 LRR_TYP, 8 hits
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403 SSF48403, 1 hit
SSF50978 SSF50978, 1 hit
SSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS51450 LRR, 11 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS51424 ROC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q38SD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGMSQRPPS MYWCVGPEES AVCPERAMET LNGAGDTGGK PSTRGGDPAA 
        60         70         80         90        100
RSRRTEGIRA AYRRGDRGGA RDLLEEACDQ CASQLEKGQL LSIPAAYGDL 
       110        120        130        140        150
EMVRYLLSKR LVELPTEPTD DNPAVVAAYF GHTAVVQELL ESLPGPCSPQ 
       160        170        180        190        200
RLLNWMLALA CQRGHLGVVK LLVLTHGADP ESYAVRKNEF PVIVRLPLYA 
       210        220        230        240        250
AIKSGNEDIA IFLLRHGAYF CSYILLDSPD PSKHLLRKYF IEASPLPSSY 
       260        270        280        290        300
PGKTALRVKW SHLRLPWVDL DWLIDISCQI TELDLSANCL ATLPSVIPWG 
       310        320        330        340        350
LINLRKLNLS DNHLGELPGV QSSDEIICSR LLEIDISSNK LSHLPPGFLH 
       360        370        380        390        400
LSKLQKLTAS KNCLEKLFEE ENATNWIGLR KLQELDISDN KLTELPALFL 
       410        420        430        440        450
HSFKSLNSLN VSRNNLKVFP DPWACPLKCC KASRNALECL PDKMAVFWKN 
       460        470        480        490        500
HLKDVDFSEN ALKEVPLGLF QLDALMFLRL QGNQLAALPP QEKWTCRQLK 
       510        520        530        540        550
TLDLSRNQLG KNEDGLKTKR IAFFTTRGRQ RSGTEAASVL EFPAFLSESL 
       560        570        580        590        600
EVLCLNDNHL DTVPPSVCLL KSLSELYLGN NPGLRELPPE LGQLGNLWQL 
       610        620        630        640        650
DTEDLTISNV PAEIQKEGPK AMLSYLRAQL RKAEKCKLMK MIIVGPPRQG 
       660        670        680        690        700
KSTLLEILQT GRAPQVVHGE ATIRTTKWEL QRPAGSRAKV ESVEFNVWDI 
       710        720        730        740        750
GGPASMATVN QCFFTDKALY VVVWNLALGE EAVANLQFWL LNIEAKAPNA 
       760        770        780        790        800
VVLVVGTHLD LIEAKFRVER IATLRAYVLA LCRSPSGSRA TGFPDITFKH 
       810        820        830        840        850
LHEISCKSLE GQEGLRQLIF HVTCSMKDVG STIGCQRLAG RLIPRSYLSL 
       860        870        880        890        900
QEAVLAEQQR RSRDDDVQYL TDRQLEQLVE QTPDNDIKDY EDLQSAISFL 
       910        920        930        940        950
IETGTLLHFP DTSHGLRNLY FLDPIWLSEC LQRIFNIKGS RSVAKNGVIR 
       960        970        980        990       1000
AEDLRMLLVG TGFTQQTEEQ YFQFLAKFEI ALPVANDSYL LPHLLPSKPG 
      1010       1020       1030       1040       1050
LDTHGMRHPT ANTIQRVFKM SFVPVGFWQR FIARMLISLA EMDLQLFENK 
      1060       1070       1080       1090       1100
KNTKSRNRKV TIYSFTGNQR NRCSTFRVKR NQTIYWQEGL LVTFDGGYLS 
      1110       1120       1130       1140       1150
VESSDVNWKK KKSGGMKIVC QSEVRDFSAM AFITDHVNSL IDQWFPALTA 
      1160       1170       1180       1190       1200
TESDGTPLME QYVPCPVCET AWAQHTDPSE KSEDVQYFDM EDCVLTAIER 
      1210       1220       1230       1240       1250
DFISCPRHPD LPVPLQELVP ELFMTDFPAR LFLENSKLEH SEDEGSVLGQ 
      1260       1270       1280       1290       1300
GGSGTVIYRA RYQGQPVAVK RFHIKKFKNF ANVPADTMLR HLRATDAMKN 
      1310       1320       1330       1340       1350
FSEFRQEASM LHALQHPCIV ALIGISIHPL CFALELAPLS SLNTVLSENA 
      1360       1370       1380       1390       1400
RDSSFIPLGH MLTQKIAYQI ASGLAYLHKK NIIFCDLKSD NILVWSLDVK 
      1410       1420       1430       1440       1450
EHINIKLSDY GISRQSFHEG ALGVEGTPGY QAPEIRPRIV YDEKVDMFSY 
      1460       1470       1480       1490       1500
GMVLYELLSG QRPALGHHQL QIAKKLSKGI RPVLGQPEEV QFRRLQALMM 
      1510       1520       1530       1540       1550
ECWDTKPEKR PLALSVVSQM KDPTFATFMY ELCCGKQTAF FSSQGQEYTV 
      1560       1570       1580       1590       1600
VFWDGKEESR NYTVVNTEKG LMEVQRMCCP GMKVSCQLQV QRSLWTATED 
      1610       1620       1630       1640       1650
QKIYIYTLKG MCPLNTPQQA LDTPAVVTCF LAVPVIKKNS YLVLAGLADG 
      1660       1670       1680       1690       1700
LVAVFPVVRG TPKDSCSYLC SHTANRSKFS IADEDARQNP YPVKAMEVVN 
      1710       1720       1730       1740       1750
SGSEVWYSNG PGLLVIDCAS LEICRRLEPY MAPSMVTSVV CSSEGRGEEV 
      1760       1770       1780       1790       1800
VWCLDDKANS LVMYHSTTYQ LCARYFCGVP SPLRDMFPVR PLDTEPPAAS 
      1810       1820       1830       1840       1850
HTANPKVPEG DSIADVSIMY SEELGTQILI HQESLTDYCS MSSYSSSPPR 
      1860       1870       1880       1890       1900
QAARSPSSLP SSPASSSSVP FSTDCEDSDM LHTPGAASDR SEHDLTPMDG 
      1910       1920       1930       1940       1950
ETFSQHLQAV KILAVRDLIW VPRRGGDVIV IGLEKDSGAQ RGRVIAVLKA 
      1960       1970       1980       1990       2000
RELTPHGVLV DAAVVAKDTV VCTFENENTE WCLAVWRGWG AREFDIFYQS 
      2010 
YEELGRLEAC TRKRR
Length:2,015
Mass (Da):225,393
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38E77EDC7C84583B
GO
Isoform 21 Publication (identifier: Q38SD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-264: ALRVKWSHLR → VSSHCLWSVF
     265-2015: Missing.

Show »
Length:264
Mass (Da):28,848
Checksum:i8E95B1F50F1DB2E4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YEW1H0YEW1_HUMAN
Leucine-rich repeat serine/threonin...
LRRK1
660Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMK9E9PMK9_HUMAN
Leucine-rich repeat serine/threonin...
LRRK1
689Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK39E9PK39_HUMAN
Leucine-rich repeat serine/threonin...
LRRK1
650Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLF8E9PLF8_HUMAN
Leucine-rich repeat serine/threonin...
LRRK1
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAY67799 differs from that shown. The cDNA contains a duplication of exon 3.Curated
The sequence BAB15547 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC85472 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti203K → R in BAC85472 (PubMed:14702039).Curated1
Sequence conflicti1938G → E in AAH66655 (PubMed:15489334).Curated1
Sequence conflicti1938G → E in BAB47419 (PubMed:11347906).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0406741803A → T1 Publication1
Natural variantiVAR_0406751824L → F1 Publication1
Natural variantiVAR_0406761847S → N1 Publication1
Natural variantiVAR_0406771927D → G1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040119255 – 264ALRVKWSHLR → VSSHCLWSVF in isoform 2. 1 Publication10
Alternative sequenceiVSP_040120265 – 2015Missing in isoform 2. 1 PublicationAdd BLAST1751

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC090907 Genomic DNA No translation available.
BC066655 mRNA Translation: AAH66655.1
BC068080 mRNA Translation: AAH68080.1
DQ013130 mRNA Translation: AAY67799.1 Sequence problems.
AK026772 mRNA Translation: BAB15547.1 Different initiation.
AK130975 mRNA Translation: BAC85472.1 Different initiation.
AK131075 mRNA Translation: BAC85125.1
AB058693 mRNA Translation: BAB47419.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42086.1 [Q38SD2-1]

NCBI Reference Sequences

More...RefSeqi		NP_078928.3, NM_024652.5 [Q38SD2-1]
XP_011520314.1, XM_011522012.2 [Q38SD2-1]
XP_011520315.1, XM_011522013.2 [Q38SD2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000388948; ENSP00000373600; ENSG00000154237 [Q38SD2-1]
ENST00000532029; ENSP00000433268; ENSG00000154237 [Q38SD2-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79705

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79705

UCSC genome browser

More...UCSCi		uc002bwq.2 human [Q38SD2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090907 Genomic DNA No translation available.
BC066655 mRNA Translation: AAH66655.1
BC068080 mRNA Translation: AAH68080.1
DQ013130 mRNA Translation: AAY67799.1 Sequence problems.
AK026772 mRNA Translation: BAB15547.1 Different initiation.
AK130975 mRNA Translation: BAC85472.1 Different initiation.
AK131075 mRNA Translation: BAC85125.1
AB058693 mRNA Translation: BAB47419.1
CCDSiCCDS42086.1 [Q38SD2-1]
RefSeqiNP_078928.3, NM_024652.5 [Q38SD2-1]
XP_011520314.1, XM_011522012.2 [Q38SD2-1]
XP_011520315.1, XM_011522013.2 [Q38SD2-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122823, 86 interactors
DIPiDIP-50235N
IntActiQ38SD2, 81 interactors
STRINGi9606.ENSP00000373600

PTM databases

iPTMnetiQ38SD2
PhosphoSitePlusiQ38SD2

Polymorphism and mutation databases

BioMutaiLRRK1
DMDMi313104220

Proteomic databases

EPDiQ38SD2
jPOSTiQ38SD2
MassIVEiQ38SD2
MaxQBiQ38SD2
PaxDbiQ38SD2
PeptideAtlasiQ38SD2
PRIDEiQ38SD2
ProteomicsDBi61644 [Q38SD2-1]
61645 [Q38SD2-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q38SD2 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2085 177 antibodies

The DNASU plasmid repository

More...DNASUi		79705

Genome annotation databases

EnsembliENST00000388948; ENSP00000373600; ENSG00000154237 [Q38SD2-1]
ENST00000532029; ENSP00000433268; ENSG00000154237 [Q38SD2-2]
GeneIDi79705
KEGGihsa:79705
UCSCiuc002bwq.2 human [Q38SD2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79705
DisGeNETi79705
EuPathDBiHostDB:ENSG00000154237.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		LRRK1
HGNCiHGNC:18608 LRRK1
HPAiENSG00000154237 Tissue enhanced (lymphoid)
MalaCardsiLRRK1
MIMi610986 gene
neXtProtiNX_Q38SD2
OpenTargetsiENSG00000154237
Orphaneti500548 Osteosclerotic metaphyseal dysplasia
PharmGKBiPA134892363

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
KOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000160363
HOGENOMiCLU_001731_0_0_1
InParanoidiQ38SD2
KOiK08843
OMAiVPCHICA
OrthoDBi14978at2759
PhylomeDBiQ38SD2
TreeFamiTF313679

Enzyme and pathway databases

SignaLinkiQ38SD2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79705 3 hits in 817 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LRRK1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LRRK1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79705
PharosiQ38SD2 Tbio

Protein Ontology

More...PROi		PR:Q38SD2
RNActiQ38SD2 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000154237 Expressed in lymph node and 168 other tissues
ExpressionAtlasiQ38SD2 baseline and differential
GenevisibleiQ38SD2 HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR032171 COR
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR027417 P-loop_NTPase
IPR000719 Prot_kinase_dom
IPR020859 ROC_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF16095 COR, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00369 LRR_TYP, 8 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50978 SSF50978, 1 hit
SSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS51450 LRR, 11 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS51424 ROC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRRK1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q38SD2
Secondary accession number(s): Q6NVH5
, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 30, 2010
Last modified: June 17, 2020
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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