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UniProtKB - Q38SD2 (LRRK1_HUMAN)
Protein
Leucine-rich repeat serine/threonine-protein kinase 1
Gene
LRRK1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Cofactori
Activity regulationi
Binding of GTP stimulates kinase activity.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 1270 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 1386 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1248 – 1256 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- GTP binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB-KW
- protein serine/threonine phosphatase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
GO - Biological processi
- bone resorption Source: Ensembl
- negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- osteoclast development Source: Ensembl
- positive regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
- positive regulation of intracellular signal transduction Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, GTP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q38SD2 |
SignaLinki | Q38SD2 |
SIGNORi | Q38SD2 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18608, LRRK1 |
MIMi | 610986, gene |
neXtProti | NX_Q38SD2 |
VEuPathDBi | HostDB:ENSG00000154237 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrion Source: HPA
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 651 | K → A: Loss of GTP/GDP-binding. 1 Publication | 1 | |
Mutagenesisi | 746 | K → G: No effect on GTP-binding but reduction in subsequent stimulation of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 1022 | F → C: No effect on GTP-binding but loss of subsequent stimulation of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 1270 | K → W: Loss of autophosphorylation. 1 Publication | 1 | |
Mutagenesisi | 1412 | I → T: No effect on GTP-binding but reduction in subsequent stimulation of kinase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 79705 |
MalaCardsi | LRRK1 |
OpenTargetsi | ENSG00000154237 |
Orphaneti | 500548, Osteosclerotic metaphyseal dysplasia |
PharmGKBi | PA134892363 |
Miscellaneous databases
Pharosi | Q38SD2, Tbio |
Genetic variation databases
BioMutai | LRRK1 |
DMDMi | 313104220 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233377 | 1 – 2015 | Leucine-rich repeat serine/threonine-protein kinase 1Add BLAST | 2015 |
Proteomic databases
EPDi | Q38SD2 |
jPOSTi | Q38SD2 |
MassIVEi | Q38SD2 |
MaxQBi | Q38SD2 |
PaxDbi | Q38SD2 |
PeptideAtlasi | Q38SD2 |
PRIDEi | Q38SD2 |
ProteomicsDBi | 61644 [Q38SD2-1] 61645 [Q38SD2-2] |
PTM databases
iPTMneti | Q38SD2 |
PhosphoSitePlusi | Q38SD2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000154237, Expressed in lymph node and 182 other tissues |
ExpressionAtlasi | Q38SD2, baseline and differential |
Genevisiblei | Q38SD2, HS |
Organism-specific databases
HPAi | ENSG00000154237, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
1 PublicationBinary interactionsi
Q38SD2
Isoform 1 [Q38SD2-1]
With | #Exp. | IntAct |
---|---|---|
CDK5RAP2 [Q96SN8] | 2 | EBI-16165296,EBI-308374 |
Isoform 2 [Q38SD2-2]
With | #Exp. | IntAct |
---|---|---|
ITGAV [P06756] | 3 | EBI-25929016,EBI-298282 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 122823, 86 interactors |
DIPi | DIP-50235N |
IntActi | Q38SD2, 82 interactors |
STRINGi | 9606.ENSP00000373600 |
Miscellaneous databases
RNActi | Q38SD2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 86 – 116 | ANK 1Add BLAST | 31 | |
Repeati | 119 – 148 | ANK 2Add BLAST | 30 | |
Repeati | 152 – 182 | ANK 3Add BLAST | 31 | |
Repeati | 193 – 222 | ANK 4Add BLAST | 30 | |
Repeati | 279 – 300 | LRR 1Add BLAST | 22 | |
Repeati | 303 – 324 | LRR 2Add BLAST | 22 | |
Repeati | 330 – 351 | LRR 3Add BLAST | 22 | |
Repeati | 353 – 374 | LRR 4Add BLAST | 22 | |
Repeati | 381 – 402 | LRR 5Add BLAST | 22 | |
Repeati | 405 – 426 | LRR 6Add BLAST | 22 | |
Repeati | 427 – 447 | LRR 7Add BLAST | 21 | |
Repeati | 451 – 472 | LRR 8Add BLAST | 22 | |
Repeati | 474 – 495 | LRR 9Add BLAST | 22 | |
Repeati | 498 – 519 | LRR 10Add BLAST | 22 | |
Repeati | 549 – 570 | LRR 11Add BLAST | 22 | |
Repeati | 572 – 594 | LRR 12Add BLAST | 23 | |
Repeati | 596 – 617 | LRR 13Add BLAST | 22 | |
Domaini | 632 – 826 | RocPROSITE-ProRule annotationAdd BLAST | 195 | |
Domaini | 1242 – 1525 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 284 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 26 – 56 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 1788 – 1810 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 1841 – 1899 | DisorderedSequence analysisAdd BLAST | 59 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1841 – 1874 | Polar residuesSequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.Curated
Keywords - Domaini
ANK repeat, Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG0192, Eukaryota KOG0619, Eukaryota |
GeneTreei | ENSGT00940000160363 |
HOGENOMi | CLU_001731_0_0_1 |
InParanoidi | Q38SD2 |
OMAi | RNHTIYW |
OrthoDBi | 14978at2759 |
PhylomeDBi | Q38SD2 |
TreeFami | TF313679 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 3.40.50.300, 1 hit 3.80.10.10, 3 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR032171, COR IPR011009, Kinase-like_dom_sf IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR027417, P-loop_NTPase IPR000719, Prot_kinase_dom IPR020859, ROC_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF16095, COR, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 3 hits SM00369, LRR_TYP, 8 hits SM00220, S_TKc, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF50978, SSF50978, 1 hit SSF52540, SSF52540, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS51450, LRR, 11 hits PS50011, PROTEIN_KINASE_DOM, 1 hit PS51424, ROC, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q38SD2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGMSQRPPS MYWCVGPEES AVCPERAMET LNGAGDTGGK PSTRGGDPAA
60 70 80 90 100
RSRRTEGIRA AYRRGDRGGA RDLLEEACDQ CASQLEKGQL LSIPAAYGDL
110 120 130 140 150
EMVRYLLSKR LVELPTEPTD DNPAVVAAYF GHTAVVQELL ESLPGPCSPQ
160 170 180 190 200
RLLNWMLALA CQRGHLGVVK LLVLTHGADP ESYAVRKNEF PVIVRLPLYA
210 220 230 240 250
AIKSGNEDIA IFLLRHGAYF CSYILLDSPD PSKHLLRKYF IEASPLPSSY
260 270 280 290 300
PGKTALRVKW SHLRLPWVDL DWLIDISCQI TELDLSANCL ATLPSVIPWG
310 320 330 340 350
LINLRKLNLS DNHLGELPGV QSSDEIICSR LLEIDISSNK LSHLPPGFLH
360 370 380 390 400
LSKLQKLTAS KNCLEKLFEE ENATNWIGLR KLQELDISDN KLTELPALFL
410 420 430 440 450
HSFKSLNSLN VSRNNLKVFP DPWACPLKCC KASRNALECL PDKMAVFWKN
460 470 480 490 500
HLKDVDFSEN ALKEVPLGLF QLDALMFLRL QGNQLAALPP QEKWTCRQLK
510 520 530 540 550
TLDLSRNQLG KNEDGLKTKR IAFFTTRGRQ RSGTEAASVL EFPAFLSESL
560 570 580 590 600
EVLCLNDNHL DTVPPSVCLL KSLSELYLGN NPGLRELPPE LGQLGNLWQL
610 620 630 640 650
DTEDLTISNV PAEIQKEGPK AMLSYLRAQL RKAEKCKLMK MIIVGPPRQG
660 670 680 690 700
KSTLLEILQT GRAPQVVHGE ATIRTTKWEL QRPAGSRAKV ESVEFNVWDI
710 720 730 740 750
GGPASMATVN QCFFTDKALY VVVWNLALGE EAVANLQFWL LNIEAKAPNA
760 770 780 790 800
VVLVVGTHLD LIEAKFRVER IATLRAYVLA LCRSPSGSRA TGFPDITFKH
810 820 830 840 850
LHEISCKSLE GQEGLRQLIF HVTCSMKDVG STIGCQRLAG RLIPRSYLSL
860 870 880 890 900
QEAVLAEQQR RSRDDDVQYL TDRQLEQLVE QTPDNDIKDY EDLQSAISFL
910 920 930 940 950
IETGTLLHFP DTSHGLRNLY FLDPIWLSEC LQRIFNIKGS RSVAKNGVIR
960 970 980 990 1000
AEDLRMLLVG TGFTQQTEEQ YFQFLAKFEI ALPVANDSYL LPHLLPSKPG
1010 1020 1030 1040 1050
LDTHGMRHPT ANTIQRVFKM SFVPVGFWQR FIARMLISLA EMDLQLFENK
1060 1070 1080 1090 1100
KNTKSRNRKV TIYSFTGNQR NRCSTFRVKR NQTIYWQEGL LVTFDGGYLS
1110 1120 1130 1140 1150
VESSDVNWKK KKSGGMKIVC QSEVRDFSAM AFITDHVNSL IDQWFPALTA
1160 1170 1180 1190 1200
TESDGTPLME QYVPCPVCET AWAQHTDPSE KSEDVQYFDM EDCVLTAIER
1210 1220 1230 1240 1250
DFISCPRHPD LPVPLQELVP ELFMTDFPAR LFLENSKLEH SEDEGSVLGQ
1260 1270 1280 1290 1300
GGSGTVIYRA RYQGQPVAVK RFHIKKFKNF ANVPADTMLR HLRATDAMKN
1310 1320 1330 1340 1350
FSEFRQEASM LHALQHPCIV ALIGISIHPL CFALELAPLS SLNTVLSENA
1360 1370 1380 1390 1400
RDSSFIPLGH MLTQKIAYQI ASGLAYLHKK NIIFCDLKSD NILVWSLDVK
1410 1420 1430 1440 1450
EHINIKLSDY GISRQSFHEG ALGVEGTPGY QAPEIRPRIV YDEKVDMFSY
1460 1470 1480 1490 1500
GMVLYELLSG QRPALGHHQL QIAKKLSKGI RPVLGQPEEV QFRRLQALMM
1510 1520 1530 1540 1550
ECWDTKPEKR PLALSVVSQM KDPTFATFMY ELCCGKQTAF FSSQGQEYTV
1560 1570 1580 1590 1600
VFWDGKEESR NYTVVNTEKG LMEVQRMCCP GMKVSCQLQV QRSLWTATED
1610 1620 1630 1640 1650
QKIYIYTLKG MCPLNTPQQA LDTPAVVTCF LAVPVIKKNS YLVLAGLADG
1660 1670 1680 1690 1700
LVAVFPVVRG TPKDSCSYLC SHTANRSKFS IADEDARQNP YPVKAMEVVN
1710 1720 1730 1740 1750
SGSEVWYSNG PGLLVIDCAS LEICRRLEPY MAPSMVTSVV CSSEGRGEEV
1760 1770 1780 1790 1800
VWCLDDKANS LVMYHSTTYQ LCARYFCGVP SPLRDMFPVR PLDTEPPAAS
1810 1820 1830 1840 1850
HTANPKVPEG DSIADVSIMY SEELGTQILI HQESLTDYCS MSSYSSSPPR
1860 1870 1880 1890 1900
QAARSPSSLP SSPASSSSVP FSTDCEDSDM LHTPGAASDR SEHDLTPMDG
1910 1920 1930 1940 1950
ETFSQHLQAV KILAVRDLIW VPRRGGDVIV IGLEKDSGAQ RGRVIAVLKA
1960 1970 1980 1990 2000
RELTPHGVLV DAAVVAKDTV VCTFENENTE WCLAVWRGWG AREFDIFYQS
2010
YEELGRLEAC TRKRR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YEW1 | H0YEW1_HUMAN | Leucine-rich repeat serine/threonin... | LRRK1 | 660 | Annotation score: | ||
E9PK39 | E9PK39_HUMAN | Leucine-rich repeat serine/threonin... | LRRK1 | 650 | Annotation score: | ||
E9PMK9 | E9PMK9_HUMAN | Leucine-rich repeat serine/threonin... | LRRK1 | 689 | Annotation score: | ||
E9PLF8 | E9PLF8_HUMAN | Leucine-rich repeat serine/threonin... | LRRK1 | 32 | Annotation score: |
Sequence cautioni
The sequence BAB15547 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC85472 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 203 | K → R in BAC85472 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1938 | G → E in AAH66655 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1938 | G → E in BAB47419 (PubMed:11347906).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_040674 | 1803 | A → T1 Publication | 1 | |
Natural variantiVAR_040675 | 1824 | L → F1 Publication | 1 | |
Natural variantiVAR_040676 | 1847 | S → N1 Publication | 1 | |
Natural variantiVAR_040677 | 1927 | D → G1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040119 | 255 – 264 | ALRVKWSHLR → VSSHCLWSVF in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_040120 | 265 – 2015 | Missing in isoform 2. 1 PublicationAdd BLAST | 1751 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC090907 Genomic DNA No translation available. BC066655 mRNA Translation: AAH66655.1 BC068080 mRNA Translation: AAH68080.1 DQ013130 mRNA Translation: AAY67799.1 Sequence problems. AK026772 mRNA Translation: BAB15547.1 Different initiation. AK130975 mRNA Translation: BAC85472.1 Different initiation. AK131075 mRNA Translation: BAC85125.1 AB058693 mRNA Translation: BAB47419.1 |
CCDSi | CCDS42086.1 [Q38SD2-1] |
RefSeqi | NP_078928.3, NM_024652.5 [Q38SD2-1] XP_011520314.1, XM_011522012.2 [Q38SD2-1] XP_011520315.1, XM_011522013.2 [Q38SD2-1] |
Genome annotation databases
Ensembli | ENST00000388948; ENSP00000373600; ENSG00000154237 ENST00000532029; ENSP00000433268; ENSG00000154237 [Q38SD2-2] |
GeneIDi | 79705 |
KEGGi | hsa:79705 |
MANE-Selecti | ENST00000388948.8; ENSP00000373600.3; NM_024652.6; NP_078928.3 |
UCSCi | uc002bwq.2, human [Q38SD2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC090907 Genomic DNA No translation available. BC066655 mRNA Translation: AAH66655.1 BC068080 mRNA Translation: AAH68080.1 DQ013130 mRNA Translation: AAY67799.1 Sequence problems. AK026772 mRNA Translation: BAB15547.1 Different initiation. AK130975 mRNA Translation: BAC85472.1 Different initiation. AK131075 mRNA Translation: BAC85125.1 AB058693 mRNA Translation: BAB47419.1 |
CCDSi | CCDS42086.1 [Q38SD2-1] |
RefSeqi | NP_078928.3, NM_024652.5 [Q38SD2-1] XP_011520314.1, XM_011522012.2 [Q38SD2-1] XP_011520315.1, XM_011522013.2 [Q38SD2-1] |
3D structure databases
SMRi | Q38SD2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122823, 86 interactors |
DIPi | DIP-50235N |
IntActi | Q38SD2, 82 interactors |
STRINGi | 9606.ENSP00000373600 |
PTM databases
iPTMneti | Q38SD2 |
PhosphoSitePlusi | Q38SD2 |
Genetic variation databases
BioMutai | LRRK1 |
DMDMi | 313104220 |
Proteomic databases
EPDi | Q38SD2 |
jPOSTi | Q38SD2 |
MassIVEi | Q38SD2 |
MaxQBi | Q38SD2 |
PaxDbi | Q38SD2 |
PeptideAtlasi | Q38SD2 |
PRIDEi | Q38SD2 |
ProteomicsDBi | 61644 [Q38SD2-1] 61645 [Q38SD2-2] |
Protocols and materials databases
ABCDi | Q38SD2, 2 sequenced antibodies |
Antibodypediai | 2085, 196 antibodies from 28 providers |
DNASUi | 79705 |
Genome annotation databases
Ensembli | ENST00000388948; ENSP00000373600; ENSG00000154237 ENST00000532029; ENSP00000433268; ENSG00000154237 [Q38SD2-2] |
GeneIDi | 79705 |
KEGGi | hsa:79705 |
MANE-Selecti | ENST00000388948.8; ENSP00000373600.3; NM_024652.6; NP_078928.3 |
UCSCi | uc002bwq.2, human [Q38SD2-1] |
Organism-specific databases
CTDi | 79705 |
DisGeNETi | 79705 |
GeneCardsi | LRRK1 |
HGNCi | HGNC:18608, LRRK1 |
HPAi | ENSG00000154237, Low tissue specificity |
MalaCardsi | LRRK1 |
MIMi | 610986, gene |
neXtProti | NX_Q38SD2 |
OpenTargetsi | ENSG00000154237 |
Orphaneti | 500548, Osteosclerotic metaphyseal dysplasia |
PharmGKBi | PA134892363 |
VEuPathDBi | HostDB:ENSG00000154237 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0192, Eukaryota KOG0619, Eukaryota |
GeneTreei | ENSGT00940000160363 |
HOGENOMi | CLU_001731_0_0_1 |
InParanoidi | Q38SD2 |
OMAi | RNHTIYW |
OrthoDBi | 14978at2759 |
PhylomeDBi | Q38SD2 |
TreeFami | TF313679 |
Enzyme and pathway databases
PathwayCommonsi | Q38SD2 |
SignaLinki | Q38SD2 |
SIGNORi | Q38SD2 |
Miscellaneous databases
BioGRID-ORCSi | 79705, 8 hits in 1067 CRISPR screens |
ChiTaRSi | LRRK1, human |
GeneWikii | LRRK1 |
GenomeRNAii | 79705 |
Pharosi | Q38SD2, Tbio |
PROi | PR:Q38SD2 |
RNActi | Q38SD2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154237, Expressed in lymph node and 182 other tissues |
ExpressionAtlasi | Q38SD2, baseline and differential |
Genevisiblei | Q38SD2, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 3.40.50.300, 1 hit 3.80.10.10, 3 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR032171, COR IPR011009, Kinase-like_dom_sf IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR027417, P-loop_NTPase IPR000719, Prot_kinase_dom IPR020859, ROC_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF16095, COR, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 3 hits SM00369, LRR_TYP, 8 hits SM00220, S_TKc, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF50978, SSF50978, 1 hit SSF52540, SSF52540, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS51450, LRR, 11 hits PS50011, PROTEIN_KINASE_DOM, 1 hit PS51424, ROC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LRRK1_HUMAN | |
Accessioni | Q38SD2Primary (citable) accession number: Q38SD2 Secondary accession number(s): Q6NVH5 Q9H5S3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 23, 2022 | |
This is version 158 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families