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Protein
Submitted name:

Cytochrome P450 2D6

Gene

CYP2D6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
LigandHemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P450 2D6Imported (EC:1.14.14.1Imported)
Gene namesi
Name:CYP2D6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiQ38LG2
PRIDEiQ38LG2

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
HOVERGENiHBG015789
KOiK17712
OrthoDBiEOG091G0BT8

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008069 Cyt_P450_E_grp-I_CYP2D-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01686 EP450ICYP2D
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q38LG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYSPGPLPL PGLGNLLHVD
60 70 80 90 100
FQNTPYCFDQ LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD
110 120 130 140 150
RPPVPITQIL GFGPRSQGVF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE
160 170 180 190 200
QWVTEEAACL CAAFANHSGR PFRPNGLLDK AVSNVIASLT CGRRFEYDDP
210 220 230 240 250
RFLRLLDLAQ EGLKEESGFL REVLNAVPVL LHIPALAGKV LRFQKAFLTQ
260 270 280 290 300
LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLRIVVA
310 320 330 340 350
DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ
360 370 380 390 400
AHMPYTTAVI HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLITNLS
410 420 430 440 450
SVLKDEAVWE KPFRFHPEHF LDAQGHFVKP EAFLPFSAGR RACLGEPLAR
460 470 480 490
MELFLFFTSL LQHFSFSVAA GQPRPSHSRV VSFLVTPSPY ELCAVPR
Length:497
Mass (Da):55,734
Last modified:November 22, 2005 - v1
Checksum:i3A4E271FBB697E88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ211353 Genomic DNA Translation: ABB01370.1
RefSeqiXP_016885819.1, XM_017030330.1
XP_016885820.1, XM_017030331.1
UniGeneiHs.648256

Genome annotation databases

GeneIDi107987478
107987479
KEGGihsa:107987478
hsa:107987479

Similar proteinsi

Entry informationi

Entry nameiQ38LG2_HUMAN
AccessioniPrimary (citable) accession number: Q38LG2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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