Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Caspase 8

Gene

CASP8

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-CFA-111465 Apoptotic cleavage of cellular proteins
R-CFA-168638 NOD1/2 Signaling Pathway
R-CFA-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-CFA-3371378 Regulation by c-FLIP
R-CFA-5213460 RIPK1-mediated regulated necrosis
R-CFA-5218900 CASP8 activity is inhibited
R-CFA-5357905 Regulation of TNFR1 signaling
R-CFA-5660668 CLEC7A/inflammasome pathway
R-CFA-69416 Dimerization of procaspase-8
R-CFA-75108 Activation, myristolyation of BID and translocation to mitochondria
R-CFA-75153 Apoptotic execution phase
R-CFA-75157 FasL/ CD95L signaling

Protein family/group databases

MEROPSiC14.009

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase 8Imported
Gene namesi
Name:CASP8Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 37

Organism-specific databases

VGNCiVGNC:38736 CASP8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSCAFG00000025192

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000017899

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 80DEDInterPro annotationAdd BLAST79
Domaini100 – 177DEDInterPro annotationAdd BLAST78
Domaini239 – 371CASPASE_P20InterPro annotationAdd BLAST133
Domaini396 – 485CASPASE_P10InterPro annotationAdd BLAST90

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00760000118912
HOGENOMiHOG000276884
HOVERGENiHBG050803
KOiK04398
OMAiIFIEMEK
OrthoDBiEOG091G05YD
TreeFamiTF102023

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR033170 Caspase-8
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR011029 DEATH-like_dom_sf
IPR001875 DED_dom
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PANTHERiPTHR10454:SF162 PTHR10454:SF162, 1 hit
PfamiView protein in Pfam
PF01335 DED, 2 hits
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00115 CASc, 1 hit
SM00031 DED, 2 hits
SUPFAMiSSF47986 SSF47986, 2 hits
SSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit
PS50168 DED, 2 hits

Sequencei

Sequence statusi: Complete.

Q38JA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFSKCLYNI GEQLDSDELA SLKFLSLDYI PQKKQEPIKD PLMLFQRLQE
60 70 80 90 100
KRMLEESNLF FLKELLFRIN RLDLLMTYLD TSKEDMQQEL QIPGRAQISA
110 120 130 140 150
YRVMLFQISE DVSKLELKSF KFLLSREISR CKLDDDLNLL DIFIEMEKRV
160 170 180 190 200
ILGERNLDTL KRICDQINKS LLKKITDYEE LNREQTMNLQ RSLDEISNDM
210 220 230 240 250
SQLPIREGSV KILPMSDSLG EQDYESETSD KVYRMKSKPR GYCLIFNNYD
260 270 280 290 300
FSVARREVPK LQSIKDRNGT DLDADALSKT FSELHFEIVH FKDATAKKIC
310 320 330 340 350
EVLQSYQSMD HSSKDCFICC ILSHGDKGII YGSDGQEAPI YELTSYFTGS
360 370 380 390 400
KCPSLAGKPK IFFIQACQGD KYQKGIAVET DSEQKEAYLE MDSSYQKRYI
410 420 430 440 450
PEDADFLLGM ATVNNCVSYR NPMEGTWYIQ SLCQSLRERC PRGEDILTIL
460 470 480
TEVNFEVSNK DDRKNMGKQM PQPTFTLRKK LFFPPN
Length:486
Mass (Da):56,500
Last modified:November 22, 2005 - v1
Checksum:i01933E67BEF3B8A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03018017 Genomic DNA No translation available.
DQ223013 mRNA Translation: ABB02414.1
RefSeqiNP_001041494.1, NM_001048029.1
XP_005640480.1, XM_005640423.1
XP_005640481.1, XM_005640424.2
XP_005640482.1, XM_005640425.1
XP_005640483.1, XM_005640426.2
XP_005640484.1, XM_005640427.1
UniGeneiCfa.24658

Genome annotation databases

EnsembliENSCAFT00000019300; ENSCAFP00000017899; ENSCAFG00000025192
GeneIDi488473
KEGGicfa:488473

Similar proteinsi

Entry informationi

Entry nameiQ38JA9_CANLF
AccessioniPrimary (citable) accession number: Q38JA9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health