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Protein

Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5

Gene

At3g26560

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in pre-mRNA splicing.Curated

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi538 – 545ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent 3'-5' RNA helicase activity Source: GO_Central
  • mRNA binding Source: TAIR
  • RNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
Biological processmRNA processing, mRNA splicing
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5Curated (EC:3.6.4.13)
Alternative name(s):
DEAH RNA helicase homolog PRP221 Publication
Gene namesi
Ordered Locus Names:At3g26560Imported
ORF Names:MFE16.8Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G26560
TAIRilocus:2088847 AT3G26560

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000551321 – 1168Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5Add BLAST1168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei411PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ38953
PRIDEiQ38953

PTM databases

iPTMnetiQ38953

Expressioni

Gene expression databases

ExpressionAtlasiQ38953 baseline and differential
GenevisibleiQ38953 AT

Interactioni

Protein-protein interaction databases

BioGridi7595, 2 interactors
STRINGi3702.AT3G26560.1

Structurei

3D structure databases

ProteinModelPortaliQ38953
SMRiQ38953
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 283S1 motifPROSITE-ProRule annotationAdd BLAST70
Domaini525 – 688Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST164
Domaini706 – 886Helicase C-terminalPROSITE-ProRule annotationAdd BLAST181

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi635 – 638DEAH boxPROSITE-ProRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi777 – 780Poly-Pro4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0922 Eukaryota
COG1185 LUCA
COG1643 LUCA
HOGENOMiHOG000175261
InParanoidiQ38953
KOiK12818
OMAiIQKAICS
OrthoDBiEOG0936015G
PhylomeDBiQ38953

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
IPR022967 S1_dom
IPR003029 S1_domain
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
PF00575 S1, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q38953-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKEELNKLN HLSLVSNVCN ELETHLGSAE KVLAEFIIDL GRHSETVDEF
60 70 80 90 100
DKNLKEAGAE MPDYFVRSLL TTIHGIYPPK PKSEKKKEEG DDQKFKGLAI
110 120 130 140 150
KDTKDKVKEL EKEIEREAEE RRREEDRNRD RDRRESGRDR DRDRNRDRDD
160 170 180 190 200
RRDRHRDRER NRGDEEGEDR RSDRRHRERG RGDGGEGEDR RRDRRAKDEY
210 220 230 240 250
VEEDKGGANE PELYQVYKGR VTRVMDAGCF VQFDKFRGKE GLVHVSQMAT
260 270 280 290 300
RRVDKAKEFV KRDMEVYVKV ISISSDKYSL SMRDVDQNTG RDLIPLRKPS
310 320 330 340 350
DEDDSSRSNP SYRTKDGQVT KTGISGIRIV EENDVAPSRR PLKKMSSPER
360 370 380 390 400
WEAKQLIASG VLRVDEFPMY DEDGDGMLYQ EEGAEEELEI EMNEDEPAFL
410 420 430 440 450
QGQTRYSVDM SPVKIFKNPE GSLSRAAALQ SALTKERREM REQQQRTMLD
460 470 480 490 500
SIPKDLNRPW EDPMPETGER HLAQELRGVG LSAYDMPEWK KDAFGKTPTF
510 520 530 540 550
GQRSKLSIQE QRESLPIYKL KKELIQAVHD NQVLVVIGET GSGKTTQVTQ
560 570 580 590 600
YLAEAGYTTK GKIGCTQPRR VAAMSVAKRV AEEFGCRLGE EVGYAIRFED
610 620 630 640 650
CTGPDTVIKY MTDGMLLREI LIDENLSQYS VIMLDEAHER TIHTDVLFGL
660 670 680 690 700
LKKLMKRRLD LRLIVTSATL DAEKFSGYFF NCNIFTIPGR TFPVEILYTK
710 720 730 740 750
QPETDYLDAA LITVLQIHLT EPEGDILVFL TGQEEIDSAC QSLYERMKGL
760 770 780 790 800
GKNVPELIIL PVYSALPSEM QSRIFDPPPP GKRKVVVATN IAEASLTIDG
810 820 830 840 850
IYYVVDPGFA KQNVYNPKQG LESLVITPIS QASAKQRAGR AGRTGPGKCY
860 870 880 890 900
RLYTESAYRN EMPPTSIPEI QRINLGMTTL TMKAMGINDL LSFDFMDPPQ
910 920 930 940 950
PQALISAMEQ LYSLGALDEE GLLTKLGRKM AEFPLEPPLS KMLLASVDLG
960 970 980 990 1000
CSDEILTMIA MIQTGNIFYR PREKQAQADQ KRAKFFQPEG DHLTLLAVYE
1010 1020 1030 1040 1050
AWKAKNFSGP WCFENFIQSR SLRRAQDVRK QLLSIMDKYK LDVVTAGKNF
1060 1070 1080 1090 1100
TKIRKAITAG FFFHGARKDP QEGYRTLVEN QPVYIHPSSA LFQRQPDWVI
1110 1120 1130 1140 1150
YHDLVMTTKE YMREVTVIDP KWLVELAPRF FKVSDPTKMS KRKRQERIEP
1160
LYDRYHEPNS WRLSKRRA
Length:1,168
Mass (Da):134,157
Last modified:January 10, 2003 - v2
Checksum:iB3632DE4A7A7690C
GO

Sequence cautioni

The sequence CAA66613 differs from that shown. Reason: Frameshift at position 57.Curated
The sequence CAA66825 differs from that shown. Reason: Frameshift at position 57.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98130 Genomic DNA Translation: CAA66825.1 Frameshift.
X97970 mRNA Translation: CAA66613.1 Frameshift.
AB028611 Genomic DNA Translation: BAB01838.1
CP002686 Genomic DNA Translation: AEE77178.1
RefSeqiNP_189288.1, NM_113564.4
UniGeneiAt.46918

Genome annotation databases

EnsemblPlantsiAT3G26560.1; AT3G26560.1; AT3G26560
GeneIDi822264
GrameneiAT3G26560.1; AT3G26560.1; AT3G26560
KEGGiath:AT3G26560

Similar proteinsi

Cross-referencesi

Web resourcesi

Splicing Related Gene Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98130 Genomic DNA Translation: CAA66825.1 Frameshift.
X97970 mRNA Translation: CAA66613.1 Frameshift.
AB028611 Genomic DNA Translation: BAB01838.1
CP002686 Genomic DNA Translation: AEE77178.1
RefSeqiNP_189288.1, NM_113564.4
UniGeneiAt.46918

3D structure databases

ProteinModelPortaliQ38953
SMRiQ38953
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi7595, 2 interactors
STRINGi3702.AT3G26560.1

PTM databases

iPTMnetiQ38953

Proteomic databases

PaxDbiQ38953
PRIDEiQ38953

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G26560.1; AT3G26560.1; AT3G26560
GeneIDi822264
GrameneiAT3G26560.1; AT3G26560.1; AT3G26560
KEGGiath:AT3G26560

Organism-specific databases

AraportiAT3G26560
TAIRilocus:2088847 AT3G26560

Phylogenomic databases

eggNOGiKOG0922 Eukaryota
COG1185 LUCA
COG1643 LUCA
HOGENOMiHOG000175261
InParanoidiQ38953
KOiK12818
OMAiIQKAICS
OrthoDBiEOG0936015G
PhylomeDBiQ38953

Miscellaneous databases

PROiPR:Q38953

Gene expression databases

ExpressionAtlasiQ38953 baseline and differential
GenevisibleiQ38953 AT

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
IPR022967 S1_dom
IPR003029 S1_domain
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
PF00575 S1, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50126 S1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEAH5_ARATH
AccessioniPrimary (citable) accession number: Q38953
Secondary accession number(s): Q9LRV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 10, 2003
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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