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Protein

Lycopene beta cyclase, chloroplastic

Gene

LCY1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in carotenoid biosynthesis. Catalyzes the double cyclization reaction which converts lycopene to beta-carotene and neurosporene to beta-zeacarotene (PubMed:8837512). Major lycopene beta-cyclase that does not seem to be involved in neoxanthin synthesis (PubMed:19549928). Involved in salt tolerance improvement by increasing synthesis of carotenoids, which impairs reactive oxygen species (ROS) and protects the photosynthetic system under salt stress (PubMed:21471119).3 Publications

Miscellaneous

Plants overexpressing LYC1 exhibit improved tolerance to salt stress.1 Publication

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.1 Publication

Pathwayi: beta-carotene biosynthesis

This protein is involved in the pathway beta-carotene biosynthesis, which is part of Carotenoid biosynthesis.Curated
View all proteins of this organism that are known to be involved in the pathway beta-carotene biosynthesis and in Carotenoid biosynthesis.

Pathwayi: beta-zeacarotene biosynthesis

This protein is involved in the pathway beta-zeacarotene biosynthesis, which is part of Carotenoid biosynthesis.Curated
View all proteins of this organism that are known to be involved in the pathway beta-zeacarotene biosynthesis and in Carotenoid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi85 – 113NADSequence analysisAdd BLAST29

GO - Molecular functioni

GO - Biological processi

  • carotenoid biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionIsomerase
Biological processCarotenoid biosynthesis, Stress response
LigandNAD

Enzyme and pathway databases

BioCyciARA:AT3G10230-MONOMER
MetaCyc:AT3G10230-MONOMER
UniPathwayiUPA00802
UPA00805

Names & Taxonomyi

Protein namesi
Recommended name:
Lycopene beta cyclase, chloroplastic1 Publication (EC:5.5.1.191 Publication)
Alternative name(s):
AtLCY1 Publication
Protein SUPPRESSOR OF ZEAXANTHIN-LESS 11 Publication
Gene namesi
Name:LCY11 Publication
Synonyms:LCYB1 Publication, LYC1 Publication, SZL11 Publication
Ordered Locus Names:At3g10230Imported
ORF Names:F14P13.17Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G10230
TAIRilocus:2076319 AT3G10230

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi451G → E in szl1; slight reduction in plant growth, increased content of lutein, and decreased content of xanthophyll pigments (violaxanthin, antheraxanthin and zeaxanthin). 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 48ChloroplastCombined sourcesAdd BLAST48
ChainiPRO_000001842949 – 501Lycopene beta cyclase, chloroplasticAdd BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49N-acetylvalineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ38933

PTM databases

iPTMnetiQ38933

Expressioni

Gene expression databases

ExpressionAtlasiQ38933 baseline and differential
GenevisibleiQ38933 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G10230.1

Structurei

3D structure databases

ProteinModelPortaliQ38933
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lycopene cyclase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IGXM Eukaryota
ENOG410XPIY LUCA
HOGENOMiHOG000224851
InParanoidiQ38933
KOiK06443
OMAiFVLMDFR
OrthoDBiEOG0936092S
PhylomeDBiQ38933

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR010108 Lycopene_cyclase_b/e
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01790 carotene-cycl, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q38933-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTLLKTPNK LDFFIPQFHG FERLCSNNPY HSRVRLGVKK RAIKIVSSVV
60 70 80 90 100
SGSAALLDLV PETKKENLDF ELPLYDTSKS QVVDLAIVGG GPAGLAVAQQ
110 120 130 140 150
VSEAGLSVCS IDPSPKLIWP NNYGVWVDEF EAMDLLDCLD TTWSGAVVYV
160 170 180 190 200
DEGVKKDLSR PYGRVNRKQL KSKMLQKCIT NGVKFHQSKV TNVVHEEANS
210 220 230 240 250
TVVCSDGVKI QASVVLDATG FSRCLVQYDK PYNPGYQVAY GIVAEVDGHP
260 270 280 290 300
FDVDKMVFMD WRDKHLDSYP ELKERNSKIP TFLYAMPFSS NRIFLEETSL
310 320 330 340 350
VARPGLRMED IQERMAARLK HLGINVKRIE EDERCVIPMG GPLPVLPQRV
360 370 380 390 400
VGIGGTAGMV HPSTGYMVAR TLAAAPIVAN AIVRYLGSPS SNSLRGDQLS
410 420 430 440 450
AEVWRDLWPI ERRRQREFFC FGMDILLKLD LDATRRFFDA FFDLQPHYWH
460 470 480 490 500
GFLSSRLFLP ELLVFGLSLF SHASNTSRLE IMTKGTVPLA KMINNLVQDR

D
Length:501
Mass (Da):56,177
Last modified:November 1, 1996 - v1
Checksum:iC3014578D0BDC4E2
GO
Isoform 2 (identifier: Q38933-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.

Note: Derived from EST data. No experimental confirmation available.Curated
Show »
Length:369
Mass (Da):41,779
Checksum:i12DC2F1258665128
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31H → P in AAA81880 (Ref. 2) Curated1
Sequence conflicti243V → I in AAA81880 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0355461 – 132Missing in isoform 2. CuratedAdd BLAST132

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50739 mRNA Translation: AAB53337.1
L40176 mRNA Translation: AAA81880.1
AF117256 Genomic DNA Translation: AAF82388.1
AC009400 Genomic DNA Translation: AAF02819.1
CP002686 Genomic DNA Translation: AEE74874.1
CP002686 Genomic DNA Translation: AEE74875.1
AY059749 mRNA Translation: AAL24097.1
AY091396 mRNA Translation: AAM14335.1
RefSeqiNP_001078131.1, NM_001084662.1 [Q38933-2]
NP_187634.1, NM_111858.2 [Q38933-1]
UniGeneiAt.1532
At.71154
At.71830

Genome annotation databases

EnsemblPlantsiAT3G10230.1; AT3G10230.1; AT3G10230 [Q38933-1]
AT3G10230.2; AT3G10230.2; AT3G10230 [Q38933-2]
GeneIDi820185
GrameneiAT3G10230.1; AT3G10230.1; AT3G10230 [Q38933-1]
AT3G10230.2; AT3G10230.2; AT3G10230 [Q38933-2]
KEGGiath:AT3G10230

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLCYB_ARATH
AccessioniPrimary (citable) accession number: Q38933
Secondary accession number(s): A8MR53, Q39145
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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