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UniProtKB - Q38932 (LCYE_ARATH)

Entry version 159 (23 Feb 2022)
Sequence version 2 (10 Jan 2003)
Previous versions | rss
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Protein

Lycopene epsilon cyclase, chloroplastic

Gene

LUT2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in carotenoid biosynthesis. Catalyzes the single epsilon-cyclization reaction which converts lycopene to delta-carotene and neurosporene to alpha-zeacarotene (PubMed:8837512, PubMed:11226339).

Required for lutein biosynthesis (PubMed:9789087).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: alpha-zeacarotene biosynthesis

This protein is involved in the pathway alpha-zeacarotene biosynthesis, which is part of Carotenoid biosynthesis.Curated
View all proteins of this organism that are known to be involved in the pathway alpha-zeacarotene biosynthesis and in Carotenoid biosynthesis.

Pathwayi: delta-carotene biosynthesis

This protein is involved in the pathway delta-carotene biosynthesis, which is part of Carotenoid biosynthesis.Curated
View all proteins of this organism that are known to be involved in the pathway delta-carotene biosynthesis and in Carotenoid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi111 – 139NADSequence analysisAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processCarotenoid biosynthesis
LigandNAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		ARA:AT5G57030-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		5.5.1.18, 399

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00801
UPA00804

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lycopene epsilon cyclase, chloroplastic1 Publication (EC:5.5.1.182 Publications)
Alternative name(s):
Protein LUTEIN DEFICIENT 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LUT21 Publication
Ordered Locus Names:At5g57030Imported
ORF Names:MHM17.16Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...Araporti		AT5G57030

The Arabidopsis Information Resource

More...TAIRi		locus:2164590, AT5G57030

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Delayed greening and virescent seedlings.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi447 – 452ALIVQF → HIVLM: Converts the enzyme from a mono- to a bi-epsilon-cyclase. 1 Publication6
Mutagenesisi447A → D: No effect on catalytic activity. 1 Publication1
Mutagenesisi448L → D: Partial loss of catalytic activity. 1 Publication1
Mutagenesisi448L → H or R: Converts the enzyme from a mono- to a bi-epsilon-cyclase. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 45ChloroplastSequence analysisAdd BLAST45
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001843446 – 524Lycopene epsilon cyclase, chloroplasticAdd BLAST479

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q38932

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		237157

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q38932, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q38932, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		3702.AT5G57030.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q38932

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the lycopene cyclase family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QT61, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_032956_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q38932

Identification of Orthologs from Complete Genome Data

More...OMAi		QTCYGIV

Database of Orthologous Groups

More...OrthoDBi		815606at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q38932

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.50.50.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036188, FAD/NAD-bd_sf
IPR010108, Lycopene_cyclase_b/e

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51905, SSF51905, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01790, carotene-cycl, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q38932-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MECVGARNFA AMAVSTFPSW SCRRKFPVVK RYSYRNIRFG LCSVRASGGG 
        60         70         80         90        100
SSGSESCVAV REDFADEEDF VKAGGSEILF VQMQQNKDMD EQSKLVDKLP 
       110        120        130        140        150
PISIGDGALD LVVIGCGPAG LALAAESAKL GLKVGLIGPD LPFTNNYGVW 
       160        170        180        190        200
EDEFNDLGLQ KCIEHVWRET IVYLDDDKPI TIGRAYGRVS RRLLHEELLR 
       210        220        230        240        250
RCVESGVSYL SSKVDSITEA SDGLRLVACD DNNVIPCRLA TVASGAASGK 
       260        270        280        290        300
LLQYEVGGPR VCVQTAYGVE VEVENSPYDP DQMVFMDYRD YTNEKVRSLE 
       310        320        330        340        350
AEYPTFLYAM PMTKSRLFFE ETCLASKDVM PFDLLKTKLM LRLDTLGIRI 
       360        370        380        390        400
LKTYEEEWSY IPVGGSLPNT EQKNLAFGAA ASMVHPATGY SVVRSLSEAP 
       410        420        430        440        450
KYASVIAEIL REETTKQINS NISRQAWDTL WPPERKRQRA FFLFGLALIV 
       460        470        480        490        500
QFDTEGIRSF FRTFFRLPKW MWQGFLGSTL TSGDLVLFAL YMFVISPNNL 
       510        520 
RKGLINHLIS DPTGATMIKT YLKV
Length:524
Mass (Da):58,491
Last modified:January 10, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C1F98CC72EDD074
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti111L → H in AAB53336 (PubMed:8837512).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U50738 mRNA Translation: AAB53336.1
AF117257 Genomic DNA Translation: AAF82389.1
AB024035 Genomic DNA Translation: BAA97033.1
CP002688 Genomic DNA Translation: AED96836.1
AY040024 mRNA Translation: AAK64181.1
AY079371 mRNA Translation: AAL85102.1

NCBI Reference Sequences

More...RefSeqi		NP_200513.1, NM_125085.5

Genome annotation databases

Ensembl plant genome annotation project

More...EnsemblPlantsi		AT5G57030.1; AT5G57030.1; AT5G57030

Database of genes from NCBI RefSeq genomes

More...GeneIDi		835806

Gramene; a comparative resource for plants

More...Gramenei		AT5G57030.1; AT5G57030.1; AT5G57030

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ath:AT5G57030

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50738 mRNA Translation: AAB53336.1
AF117257 Genomic DNA Translation: AAF82389.1
AB024035 Genomic DNA Translation: BAA97033.1
CP002688 Genomic DNA Translation: AED96836.1
AY040024 mRNA Translation: AAK64181.1
AY079371 mRNA Translation: AAL85102.1
RefSeqiNP_200513.1, NM_125085.5

3D structure databases

SMRiQ38932
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G57030.1

Proteomic databases

PaxDbiQ38932
ProteomicsDBi237157

Genome annotation databases

EnsemblPlantsiAT5G57030.1; AT5G57030.1; AT5G57030
GeneIDi835806
GrameneiAT5G57030.1; AT5G57030.1; AT5G57030
KEGGiath:AT5G57030

Organism-specific databases

AraportiAT5G57030
TAIRilocus:2164590, AT5G57030

Phylogenomic databases

eggNOGiENOG502QT61, Eukaryota
HOGENOMiCLU_032956_1_0_1
InParanoidiQ38932
OMAiQTCYGIV
OrthoDBi815606at2759
PhylomeDBiQ38932

Enzyme and pathway databases

UniPathwayiUPA00801
UPA00804
BioCyciARA:AT5G57030-MONOMER
BRENDAi5.5.1.18, 399

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q38932

Gene expression databases

ExpressionAtlasiQ38932, baseline and differential
GenevisibleiQ38932, AT

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188, FAD/NAD-bd_sf
IPR010108, Lycopene_cyclase_b/e
SUPFAMiSSF51905, SSF51905, 1 hit
TIGRFAMsiTIGR01790, carotene-cycl, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLCYE_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q38932
Secondary accession number(s): Q9LDV8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 10, 2003
Last modified: February 23, 2022
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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