UniProtKB - Q38876 (AGL8_ARATH)
Agamous-like MADS-box protein AGL8
AGL8
Functioni
Probable transcription factor that promotes early floral meristem identity in synergy with APETALA1 and CAULIFLOWER. Is required subsequently for the transition of an inflorescence meristem into a floral meristem (PubMed:28586421).
Seems to be partially redundant to the function of APETALA1 and CAULIFLOWER in the up-regulation of LEAFY. Is also required for normal pattern of cell division, expansion and differentiation during morphogenesis of the silique (PubMed:28586421).
Probably not required for fruit elongation but instead is required to prevent ectopic activity of IND. Represses SAUR10 expression in stems and inflorescence branches (PubMed:28586421).
4 PublicationsGO - Molecular functioni
- DNA-binding transcription factor activity Source: TAIR
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: UniProtKB
- transcription cis-regulatory region binding Source: TAIR
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- developmental growth involved in morphogenesis Source: UniProtKB
- flower development Source: UniProtKB-KW
- fruit development Source: TAIR
- maintenance of inflorescence meristem identity Source: TAIR
- positive regulation of flower development Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: InterPro
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Differentiation, Flowering, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Agamous-like MADS-box protein AGL8Alternative name(s): Floral homeotic protein AGL8 Transcription factor FRUITFULL |
Gene namesi | Name:AGL8 Synonyms:FUL Ordered Locus Names:At5g60910 ORF Names:MSL3.3 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G60910 |
TAIRi | locus:2173522, AT5G60910 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000199461 | 1 – 242 | Agamous-like MADS-box protein AGL8Add BLAST | 242 |
Proteomic databases
PaxDbi | Q38876 |
ProteomicsDBi | 244732 [Q38876-1] |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
ExpressionAtlasi | Q38876, baseline and differential |
Genevisiblei | Q38876, AT |
Interactioni
Subunit structurei
Homodimer capable of binding to CArG-box sequences.
By similarityBinary interactionsi
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 21456, 17 interactors |
DIPi | DIP-33794N |
IntActi | Q38876, 19 interactors |
STRINGi | 3702.AT5G60910.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 57 | MADS-boxPROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 88 – 178 | K-boxPROSITE-ProRule annotationAdd BLAST | 91 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 89 – 178 | Sequence analysisAdd BLAST | 90 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0014, Eukaryota |
HOGENOMi | CLU_053053_0_2_1 |
InParanoidi | Q38876 |
OMAi | ISQIENW |
PhylomeDBi | Q38876 |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR033896, MADS_MEF2-like IPR002487, TF_Kbox IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF01486, K-box, 1 hit PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS51297, K_BOX, 1 hit PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketThis entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGRGRVQLKR IENKINRQVT FSKRRSGLLK KAHEISVLCD AEVALIVFSS
60 70 80 90 100
KGKLFEYSTD SCMERILERY DRYLYSDKQL VGRDVSQSEN WVLEHAKLKA
110 120 130 140 150
RVEVLEKNKR NFMGEDLDSL SLKELQSLEH QLDAAIKSIR SRKNQAMFES
160 170 180 190 200
ISALQKKDKA LQDHNNSLLK KIKEREKKTG QQEGQLVQCS NSSSVLLPQY
210 220 230 240
CVTSSRDGFV ERVGGENGGA SSLTEPNSLL PAWMLRPTTT NE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA8MRX9 | A8MRX9_ARATH | AGAMOUS-like 8 | AGL8 AGAMOUS-like 8, FRUITFULL, FUL, MSL3.30, MSL3_30 | 180 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33473 mRNA Translation: AAA97403.1 AB008269 Genomic DNA Translation: BAB10640.1 CP002688 Genomic DNA Translation: AED97395.1 AF386929 mRNA Translation: AAK62374.1 AY072463 mRNA Translation: AAL66878.1 |
PIRi | S71208 |
RefSeqi | NP_568929.1, NM_125484.4 [Q38876-1] |
Genome annotation databases
EnsemblPlantsi | AT5G60910.1; AT5G60910.1; AT5G60910 [Q38876-1] |
GeneIDi | 836212 |
Gramenei | AT5G60910.1; AT5G60910.1; AT5G60910 [Q38876-1] |
KEGGi | ath:AT5G60910 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33473 mRNA Translation: AAA97403.1 AB008269 Genomic DNA Translation: BAB10640.1 CP002688 Genomic DNA Translation: AED97395.1 AF386929 mRNA Translation: AAK62374.1 AY072463 mRNA Translation: AAL66878.1 |
PIRi | S71208 |
RefSeqi | NP_568929.1, NM_125484.4 [Q38876-1] |
3D structure databases
AlphaFoldDBi | Q38876 |
SMRi | Q38876 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 21456, 17 interactors |
DIPi | DIP-33794N |
IntActi | Q38876, 19 interactors |
STRINGi | 3702.AT5G60910.1 |
Proteomic databases
PaxDbi | Q38876 |
ProteomicsDBi | 244732 [Q38876-1] |
Genome annotation databases
EnsemblPlantsi | AT5G60910.1; AT5G60910.1; AT5G60910 [Q38876-1] |
GeneIDi | 836212 |
Gramenei | AT5G60910.1; AT5G60910.1; AT5G60910 [Q38876-1] |
KEGGi | ath:AT5G60910 |
Organism-specific databases
Araporti | AT5G60910 |
TAIRi | locus:2173522, AT5G60910 |
Phylogenomic databases
eggNOGi | KOG0014, Eukaryota |
HOGENOMi | CLU_053053_0_2_1 |
InParanoidi | Q38876 |
OMAi | ISQIENW |
PhylomeDBi | Q38876 |
Miscellaneous databases
PROi | PR:Q38876 |
Gene expression databases
ExpressionAtlasi | Q38876, baseline and differential |
Genevisiblei | Q38876, AT |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR033896, MADS_MEF2-like IPR002487, TF_Kbox IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF01486, K-box, 1 hit PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS51297, K_BOX, 1 hit PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AGL8_ARATH | |
Accessioni | Q38876Primary (citable) accession number: Q38876 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names