Agamous-like MADS-box protein AGL15

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.10

    "Binding site selection for the plant MADS domain protein AGL15: an in vitro and in vivo study."
    Tang W., Perry S.E.
    J. Biol. Chem. 278:28154-28159(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.20

    "Arabidopsis cold shock domain proteins: relationships to floral and silique development."
    Nakaminami K., Hill K., Perry S.E., Sentoku N., Long J.A., Karlson D.T.
    J. Exp. Bot. 60:1047-1062(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS TRANSCRIPTION FACTOR.
• DNA-binding transcription factor activity Source: TAIRInferred from direct assayⁱ
  • "The class III peroxidase PRX17 is a direct target of the MADS-box transcription factor AGAMOUS-LIKE15 (AGL15) and participates in lignified tissue formation."
    Cosio C., Ranocha P., Francoz E., Burlat V., Zheng Y., Perry S.E., Ripoll J.J., Yanofsky M., Dunand C.
    New Phytol. 213:250-263(2017) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.15

    "Comprehensive interaction map of the Arabidopsis MADS Box transcription factors."
    de Folter S., Immink R.G.H., Kieffer M., Parenicova L., Henz S.R., Weigel D., Busscher M., Kooiker M., Colombo L., Kater M.M., Davies B., Angenent G.C.
    Plant Cell 17:1424-1433(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH AGL15; SVP; AGL24; AP1; AGL6; AG; AGL1; AGL11; AGL5; AGL16; SOC1 AND AGL21.
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: TAIRInferred from direct assayⁱ
  • "The class III peroxidase PRX17 is a direct target of the MADS-box transcription factor AGAMOUS-LIKE15 (AGL15) and participates in lignified tissue formation."
    Cosio C., Ranocha P., Francoz E., Burlat V., Zheng Y., Perry S.E., Ripoll J.J., Yanofsky M., Dunand C.
    New Phytol. 213:250-263(2017) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to auxin stimulus Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.16

    "Control of expression and autoregulation of AGL15, a member of the MADS-box family."
    Zhu C., Perry S.E.
    Plant J. 41:583-594(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION BY AUXIN.
• embryo development ending in seed dormancy Source: TAIRInferred from direct assayⁱ
  • Ref.21

    "Global identification of targets of the Arabidopsis MADS domain protein AGAMOUS-Like15."
    Zheng Y., Ren N., Wang H., Stromberg A.J., Perry S.E.
    Plant Cell 21:2563-2577(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS TRANSCRIPTION ACTIVATOR.
• floral organ abscission Source: TAIR <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Floral organ abscission is regulated by a positive feedback loop."
    Patharkar O.R., Walker J.C.
    Proc. Natl. Acad. Sci. U.S.A. 112:2906-2911(2015) [PubMed] [Europe PMC] [Abstract]
• fruit abscission Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.9

    "Effect of regulated overexpression of the MADS domain factor AGL15 on flower senescence and fruit maturation."
    Fang S.-C., Fernandez D.E.
    Plant Physiol. 130:78-89(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• fruit dehiscence Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.9

    "Effect of regulated overexpression of the MADS domain factor AGL15 on flower senescence and fruit maturation."
    Fang S.-C., Fernandez D.E.
    Plant Physiol. 130:78-89(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• gibberellin catabolic process Source: TAIR <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.21

    "Global identification of targets of the Arabidopsis MADS domain protein AGAMOUS-Like15."
    Zheng Y., Ren N., Wang H., Stromberg A.J., Perry S.E.
    Plant Cell 21:2563-2577(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS TRANSCRIPTION ACTIVATOR.
• multicellular organism development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of floral organ abscission Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.8

    "The embryo MADS domain factor AGL15 acts postembryonically. Inhibition of perianth senescence and abscission via constitutive expression."
    Fernandez D.E., Heck G.R., Perry S.E., Patterson S.E., Bleecker A.B., Fang S.-C.
    Plant Cell 12:183-198(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
  • Ref.9

    "Effect of regulated overexpression of the MADS domain factor AGL15 on flower senescence and fruit maturation."
    Fang S.-C., Fernandez D.E.
    Plant Physiol. 130:78-89(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• negative regulation of flower development Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.18

    "The MADS domain factors AGL15 and AGL18 act redundantly as repressors of the floral transition in Arabidopsis."
    Adamczyk B.J., Lehti-Shiu M.D., Fernandez D.E.
    Plant J. 50:1007-1019(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
• negative regulation of gene expression Source: TAIRInferred from mutant phenotypeⁱ
  • "The class III peroxidase PRX17 is a direct target of the MADS-box transcription factor AGAMOUS-LIKE15 (AGL15) and participates in lignified tissue formation."
    Cosio C., Ranocha P., Francoz E., Burlat V., Zheng Y., Perry S.E., Ripoll J.J., Yanofsky M., Dunand C.
    New Phytol. 213:250-263(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of seed maturation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.9

    "Effect of regulated overexpression of the MADS domain factor AGL15 on flower senescence and fruit maturation."
    Fang S.-C., Fernandez D.E.
    Plant Physiol. 130:78-89(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• negative regulation of short-day photoperiodism, flowering Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.18

    "The MADS domain factors AGL15 and AGL18 act redundantly as repressors of the floral transition in Arabidopsis."
    Adamczyk B.J., Lehti-Shiu M.D., Fernandez D.E.
    Plant J. 50:1007-1019(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.20

    "Arabidopsis cold shock domain proteins: relationships to floral and silique development."
    Nakaminami K., Hill K., Perry S.E., Sentoku N., Long J.A., Karlson D.T.
    J. Exp. Bot. 60:1047-1062(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS TRANSCRIPTION FACTOR.
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.20

    "Arabidopsis cold shock domain proteins: relationships to floral and silique development."
    Nakaminami K., Hill K., Perry S.E., Sentoku N., Long J.A., Karlson D.T.
    J. Exp. Bot. 60:1047-1062(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS TRANSCRIPTION FACTOR.
• positive regulation of transcription by RNA polymerase II Source: InterPro
• somatic embryogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.19

    "The MADS-domain transcriptional regulator AGAMOUS-LIKE15 promotes somatic embryo development in Arabidopsis and soybean."
    Thakare D., Tang W., Hill K., Perry S.E.
    Plant Physiol. 146:1663-1672(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• protein homodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.15

    "Comprehensive interaction map of the Arabidopsis MADS Box transcription factors."
    de Folter S., Immink R.G.H., Kieffer M., Parenicova L., Henz S.R., Weigel D., Busscher M., Kooiker M., Colombo L., Kater M.M., Davies B., Angenent G.C.
    Plant Cell 17:1424-1433(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH AGL15; SVP; AGL24; AP1; AGL6; AG; AGL1; AGL11; AGL5; AGL16; SOC1 AND AGL21.
• transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MGRGKIEIKR IENANSRQVT FSKRRSGLLK KARELSVLCD AEVAVIVFSK 
        60         70         80         90        100
SGKLFEYSST GMKQTLSRYG NHQSSSASKA EEDCAEVDIL KDQLSKLQEK 
       110        120        130        140        150
HLQLQGKGLN PLTFKELQSL EQQLYHALIT VRERKERLLT NQLEESRLKE 
       160        170        180        190        200
QRAELENETL RRQVQELRSF LPSFTHYVPS YIKCFAIDPK NALINHDSKC 
       210        220        230        240        250
SLQNTDSDTT LQLGLPGEAH DRRTNEGERE SPSSDSVTTN TSSETAERGD 
       260 
QSSLANSPPE AKRQRFSV                                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Arabidopsis thaliana
   Arabidopsis thaliana: entries and gene names