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Protein

Auxin-responsive protein IAA8

Gene

IAA8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.1 Publication

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processAuxin signaling pathway, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Auxin-responsive protein IAA8
Alternative name(s):
Indoleacetic acid-induced protein 8
Gene namesi
Name:IAA8
Ordered Locus Names:At2g22670
ORF Names:T9I22.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G22670

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001128391 – 321Auxin-responsive protein IAA8Add BLAST321

Proteomic databases

PaxDbiQ38826
PRIDEiQ38826

PTM databases

iPTMnetiQ38826

Expressioni

Tissue specificityi

Highly expressed in the whole plant.1 Publication

Inductioni

By auxin.1 Publication

Gene expression databases

ExpressionAtlasiQ38826 baseline and differential
GenevisibleiQ38826 AT

Interactioni

Subunit structurei

Homodimers and heterodimers (By similarity). Interacts with TPL.By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi2151, 41 interactors
ELMiQ38826
IntActiQ38826, 38 interactors
STRINGi3702.AT2G22670.4

Structurei

3D structure databases

ProteinModelPortaliQ38826
SMRiQ38826
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini199 – 301PB1PROSITE-ProRule annotationAdd BLAST103

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi54 – 58EAR-like (transcriptional repression)5

Domaini

The N-terminal half of the protein contains two conserved domains I and II. Domain I includes a slightly degenerated ERF-associated amphiphilic repression (EAR) motif which seems to be involved in the activity of transcriptional repression. Domain II is required for the correct degradation of the protein through the SCF-mediated ubiquitin-proteasome pathway. Interactions between Aux/IAA proteins and auxin response factors (ARFs) occur through their C-terminal dimerization domains III and IV.

Sequence similaritiesi

Belongs to the Aux/IAA family.Curated

Phylogenomic databases

eggNOGiENOG410IV98 Eukaryota
ENOG4111VTJ LUCA
HOGENOMiHOG000238261
InParanoidiQ38826
KOiK14484
PhylomeDBiQ38826

Family and domain databases

InterProiView protein in InterPro
IPR033389 AUX/IAA_dom
IPR003311 AUX_IAA
IPR000270 PB1_dom
PANTHERiPTHR31734 PTHR31734, 1 hit
PfamiView protein in Pfam
PF02309 AUX_IAA, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q38826-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYRLLSVDK DELVTSPCLK ERNYLGLSDC SSVDSSTIPN VVGKSNLNFK
60 70 80 90 100
ATELRLGLPE SQSPERETDF GLLSPRTPDE KLLFPLLPSK DNGSATTGHK
110 120 130 140 150
NVVSGNKRGF ADTWDEFSGV KGSVRPGGGI NMMLSPKVKD VSKSIQEERS
160 170 180 190 200
HAKGGLNNAP AAKAQVVGWP PIRSYRKNTM ASSTSKNTDE VDGKPGLGVL
210 220 230 240 250
FVKVSMDGAP YLRKVDLRTY TSYQQLSSAL EKMFSCFTLG QCGLHGAQGR
260 270 280 290 300
ERMSEIKLKD LLHGSEFVLT YEDKDGDWML VGDVPWEIFT ETCQKLKIMK
310 320
GSDSIGLAPG AVEKSKNKER V
Length:321
Mass (Da):35,118
Last modified:November 1, 1996 - v1
Checksum:i645F2A5248BCE2FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18410 mRNA Translation: AAC49049.1
AC006340 Genomic DNA Translation: AAD15575.1
CP002685 Genomic DNA Translation: AEC07336.1
CP002685 Genomic DNA Translation: AEC07338.1
AF334714 mRNA Translation: AAG50092.1
AY059905 mRNA Translation: AAL24387.1
AY070399 mRNA Translation: AAL49895.1
AY096452 mRNA Translation: AAM20092.1
AY114671 mRNA Translation: AAM47990.1
AY087635 mRNA Translation: AAM65174.1
PIRiS58495
RefSeqiNP_001077943.1, NM_001084474.1 [Q38826-1]
NP_179852.1, NM_127832.3 [Q38826-1]
UniGeneiAt.10796
At.67150

Genome annotation databases

EnsemblPlantsiAT2G22670.1; AT2G22670.1; AT2G22670 [Q38826-1]
AT2G22670.3; AT2G22670.3; AT2G22670 [Q38826-1]
AT2G22670.4; AT2G22670.4; AT2G22670
GeneIDi816798
GrameneiAT2G22670.1; AT2G22670.1; AT2G22670 [Q38826-1]
AT2G22670.3; AT2G22670.3; AT2G22670 [Q38826-1]
AT2G22670.4; AT2G22670.4; AT2G22670
KEGGiath:AT2G22670

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIAA8_ARATH
AccessioniPrimary (citable) accession number: Q38826
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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