Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 69 (08 May 2019)
Sequence version 1 (22 Nov 2005)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Calpain-like cysteine peptidase, putative

Gene

Tb11.47.0035

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calpain-like cysteine peptidase, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:Tb11.47.0035Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri185431 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008524 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11 Scaffold 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
TriTrypDB:Tb927.11.1130

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q387D9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 304Calpain catalyticInterPro annotationAdd BLAST274
Domaini624 – 920Calpain catalyticInterPro annotationAdd BLAST297
Domaini5530 – 5799Calpain catalyticInterPro annotationAdd BLAST270

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1441 – 1461Sequence analysisAdd BLAST21
Coiled coili2738 – 2758Sequence analysisAdd BLAST21
Coiled coili2804 – 2824Sequence analysisAdd BLAST21
Coiled coili3470 – 3490Sequence analysisAdd BLAST21
Coiled coili3687 – 3707Sequence analysisAdd BLAST21
Coiled coili4080 – 4100Sequence analysisAdd BLAST21
Coiled coili4141 – 4161Sequence analysisAdd BLAST21
Coiled coili5290 – 5310Sequence analysisAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000258182

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q387D9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR036213 Calpain_III_sf
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00704 CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00230 CysPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49758 SSF49758, 2 hits
SSF54001 SSF54001, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203 CALPAIN_CAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q387D9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNYQAITEIP DSNTIFHDTI FMRNNKHVSE QWIRIGELYP NGAKESLLPE
60 70 80 90 100
TFAREQFGQG SHYECFMLSA LATLVKFPDI IRNCFVSRNV RRDGRYTFQF
110 120 130 140 150
FRDKEWVKVE IDDSVMLEDD EVLFIRSPTS HWWPLLFEKA YAKFYTSYDN
160 170 180 190 200
LEGCTLQEAY HDLTGNPVLN IPMDARLAKA AGVDVTGGQY WLDLAQKLQS
210 220 230 240 250
GQFVGSLLTR ETDLESMGLQ SEQQYGILEI FSLTGTSSVS DIVIHLYNPF
260 270 280 290 300
EDEEFTYKGP LNSKDTEWTP KLREKYNVDD THSIFLPLHV ALKIVNSVQL
310 320 330 340 350
CYISPIDGDA TYFDDEWKGE TAGGNPTSVT WRKNPLYCVR NAGINPVELV
360 370 380 390 400
VVIKQKDQRR YMSSEERTMY LQCGIVVVQS TTVTQIPTYF VTGNNHKAIH
410 420 430 440 450
KSLFLNSREV SSFVRIPPNS LCYLVPSCMK KGAESAFTLA LYRVKLQDYS
460 470 480 490 500
NILIKKLEVP SMDWGHCAIG KVTLETKVKE RVDFFVDCPT DIHILMHQEK
510 520 530 540 550
PFVNKVGGDI TTRDYVGVYL YDDTDRKIGG VHAATNFRET SVLHRLPRSG
560 570 580 590 600
RYAISITCPR ASGEVPIALT IVGSPDANVR IVEAPDDASM FDDEDDIAEG
610 620 630 640 650
DEDATVSNPI DYIPVAGGGQ VFTEVPDSTV PFEDKRFMVD NKIMTNEPWI
660 670 680 690 700
HIGDLYPEGK TRSLLPERLS REQFEQGEHF ECCCLTAFAA LVEHHPNVIR
710 720 730 740 750
DAFVTKAVRR DGRYTFRFHR YGQWVKVEID DRIPLLGGKT LFCRSSDGYW
760 770 780 790 800
WPLLLEKAYA KFYTLYQNIE GCTLRELFYD LTGLPVLSIP MELKLAKAVL
810 820 830 840 850
CDVDDVSFWV ELSEGLKDCA CAAVARPGFD DTLGLSNGQE YAVLDVVSLT
860 870 880 890 900
DGEASSISDL VVKLHNPFLE TEYKGPMNAS DAAWSSELRT RLCPERRDTI
910 920 930 940 950
YIPVEVFCNA FLTVEKVMVR GLIVPGWQFN SEWGEGTNGG NPTLVTWREN
960 970 980 990 1000
PIYVVQNTAD TPLQIIAMIG QPDQRRVLHL LPEQEVNYVQ CGLVLSQCTC
1010 1020 1030 1040 1050
SNPVPTYLVT SNNHRVVHKG LFVNFRESAN IVTIPANSMS YLIPSAMFRD
1060 1070 1080 1090 1100
KTKFLLSYWF QKLPDMKFIK ISRINVSVAR SLPAIEHLEL HNHEKKRVDF
1110 1120 1130 1140 1150
LVDVPTDIHI LLRQEKPCVT VRTHDAMADD FLGIYLYNED EKRIDGVTAA
1160 1170 1180 1190 1200
TNYREMGLVH RLATAGRYAL SITCPRGTGV VPCRVEIVGV EDAKVRITDP
1210 1220 1230 1240 1250
PEDAGNLCEV DLRFLGSEAE GVPLEDLPLD SDADLQAILE ELRRLHGDID
1260 1270 1280 1290 1300
ANAEPIAKHE RMMSDRVHKM ARQLLAKDRS KYLPGYDLQT VNSILDAEPH
1310 1320 1330 1340 1350
FVVLERDRYH LKGDPRNATK VRNVERSLLT LANEILEKHD DPDLSFLGAE
1360 1370 1380 1390 1400
VEGIPTLDLT LMSDSSFSEM ARERMQLKRD PIANASRLAE VEDSMVARAN
1410 1420 1430 1440 1450
AIAKEMHLRE RRYLNPEPEG VPLELLPLNE DEVVSEKEDR LRALNRKERK
1460 1470 1480 1490 1500
DEKLLRSLED VIADRVHEIA RELKLSERDL FLDPTPGGFP VAQLPLDEDD
1510 1520 1530 1540 1550
VFHSLEVERL QLRLRQDSLA NKTSEIKELE SWLNRRACEL ARVKVEEGRA
1560 1570 1580 1590 1600
FLDPEPLGFP LTDLNLDGDS EFVKLESELR KLRWEPRVNS TAMRTVEEDI
1610 1620 1630 1640 1650
ARVVYRIALR KTCLDRDYLD AEYEGRPVQG LPLNDSKEVL AMETRRRVLI
1660 1670 1680 1690 1700
NAKADRDEIG VAENMIRDAV REIARALNVG ERLDYLEPCP RGVPVEDLPL
1710 1720 1730 1740 1750
DMDTEFHELE VHRQRLKCDA KKQDTVIMDV ERALNDRAEA LAREHLSSDR
1760 1770 1780 1790 1800
GYLDPASVGV PLRLLPLDSD SVFQELEIKR ALLKKNPQRN GRAISALEGG
1810 1820 1830 1840 1850
LNERAHVLAT EMKHAERSKF MDPNPGGIAI EDVPIDNDEV FCDLEIRRFG
1860 1870 1880 1890 1900
LCEDPHANIA AIRNLEDAMN ERVIELADKM RCEIRMFLDP MPLGVSLDEL
1910 1920 1930 1940 1950
PLDNNESFVA KEAELHKLRK DLRANGADVA LLKSDLNELA KQMAAEMISK
1960 1970 1980 1990 2000
DRAFLFPEPE GRLLEELPLD SDKEFRSLEK QLRLLCKESP PEAQKIAAIE
2010 2020 2030 2040 2050
ELLDGRAHQL AKMKNCAERK DYLISHPCGV PLDDVPLDND DEFSMLEVKR
2060 2070 2080 2090 2100
AALMRDVVGN KDSIASVEKA LNGRAEKLAL LKLRSERSFL DPEPHGIPLH
2110 2120 2130 2140 2150
CVPLDDDDNF HLLEVERLTL KGLNIRENDR KLVGVENAMR DYVNDLALEV
2160 2170 2180 2190 2200
KRKMREDVLD TSPDGLPLSV LPLDNDLPFI ELENGYIKAV FDAKDTLKIQ
2210 2220 2230 2240 2250
DLAGAMRRRS EDIARKLRSD VRLSLEQHPL GFTLDELPVD DSELFLGKER
2260 2270 2280 2290 2300
ELLELKQDGR YNSPTAIEIM EELNSIILDI AKEQAIRERE FLDQEPEGRH
2310 2320 2330 2340 2350
ITELNLDSDT TFLGLERQRR LLKKDPFADR SRIVDLEQML NDRSHELAKK
2360 2370 2380 2390 2400
LNSLDRPKFL PVAIRGVLLS ELPLDSDAEF TRLEVERSSL YRDPVRNAST
2410 2420 2430 2440 2450
INHVEEALNI RVAAMADEVV RQDRMFLGED VEGVCVRHLP LDDDAEFRAL
2460 2470 2480 2490 2500
ETKRATYKSC GSRMGTKAIK DLEDQLGDRA AELARTAKKE LRNLLGTEPL
2510 2520 2530 2540 2550
GVPLSDLPID VDGRFRALED NYRDLSRNSA NGGKLCEIIL QLNERALELA
2560 2570 2580 2590 2600
AELHTKERVV LSQCPGGIPL SALALNEDEM FKALETEARK LRHSTAGRGR
2610 2620 2630 2640 2650
NAARISELES AMNERAMELA NQLRRTYCDA APEGIPLELL GLGGVEEFTK
2660 2670 2680 2690 2700
LEDALRDATK DPVKNREIIS DIEFELNSRA HVAAMGLLEG DRDYLECETM
2710 2720 2730 2740 2750
EVPLSDLPLN TDSVFRALEV ERAVLKLREP HRGARRVREL ELKLVERAHR
2760 2770 2780 2790 2800
LAEELKEEDL SGLDGEPEGV SLRALKPHND SLFSEFVGAM RKLKRGPKRN
2810 2820 2830 2840 2850
TVAIEELRER MNERAHELAQ EKLKDDREFL DQCPEGVPLS DLPLGTDPLF
2860 2870 2880 2890 2900
HKLETERARL KERDAARNIT HIHELESRLK ERAVELANEQ KGRDLSELEQ
2910 2920 2930 2940 2950
SPCGVPIYIL QLHDDPVLQK MLNKMRGLRN RGVTGPEFVA LIDEINNCAR
2960 2970 2980 2990 3000
DAAEELLLRD REYLEPEPLG VPLSLLSLTT DTVFHGLEVQ RAVLKAQNAR
3010 3020 3030 3040 3050
RNAAKISDFE MRLNERAVQL AEVQRQRELE GLDPEPEGIP ISVLNPHGDV
3060 3070 3080 3090 3100
EFIKLVTELR QLCSEGNNEG MCDVLKTTMN DVVHALAKRL KEGDRGYLDP
3110 3120 3130 3140 3150
EPEGVPLCVL PLDTDVLFFR LECERVTLKA RNAHLNARRI CELEDALNNR
3160 3170 3180 3190 3200
AVELAREQLR QDVNGVDEAP CGIPLQLLRL HEDSTFLVMV DDIRTLRKNP
3210 3220 3230 3240 3250
DANSEAIDAV VMSMNDRAYD VAIAQFDRGF LDPEPEGVPL CILPLDDDEL
3260 3270 3280 3290 3300
FHGMEVERIK LKLTDARRNA QTIGTLEEEM NGRAHELALQ QLREELSGID
3310 3320 3330 3340 3350
AAPEGIPLSL LRVMEDPAFA LMVLELRDLK KGTQGNAERI REVEDAMNNR
3360 3370 3380 3390 3400
AYELADGLLE GDRSYLDPIP LGVPVSELPL CSDEPFATME VERARLKAED
3410 3420 3430 3440 3450
ARRNAAGIGE LELKLNNRAK ELASEQLLRD LEGFHDEYEG IDLAHLRPHD
3460 3470 3480 3490 3500
DKEFVSLVPE LRRLKRDGDK EAVEQHMRSM DRRLRELAKE LVGGDLWFLD
3510 3520 3530 3540 3550
KEPEGVPLTY LPLDGDEILD KLRHERAQLK IQDPRGNADR IAELERKMNE
3560 3570 3580 3590 3600
RIHDLARCIG DEDFDGVEGE PCGIPLSLLS PRDDEVVAKL INDIRKVKYS
3610 3620 3630 3640 3650
TGEKSSNGAL NNLQVELSKR VHQLAEDVLI RDRVKYLNQC PESVDISFLP
3660 3670 3680 3690 3700
LSTDEQFRAL ELERVIINIQ SNGDDKRLDG LEDMLNKRAH ELAKEQLQED
3710 3720 3730 3740 3750
LRGLEQAPHG VPLDVLKPHS DLRFIKEAEQ LRNLKRDPLR NKREIDDLVE
3760 3770 3780 3790 3800
QMNNTVGELA LNLLRSDRDY LHLAPEGVPI EELPLEVDAK FCALEAERAM
3810 3820 3830 3840 3850
LKGENNPKNA SMILSLEEKL NERARQLAQE QLLEDLKELS SFQHCVPLSL
3860 3870 3880 3890 3900
LSPHTDVQFA ADVAEFRRLK KEGEQNTPAI QGVVGRLNAR ANELAEEYLR
3910 3920 3930 3940 3950
TDRASYLNPE QLGVPLDLLS LDTDSEFVSL EAERLKLLSY PAVNNEQITR
3960 3970 3980 3990 4000
LEAELNACAK KLLVKRLYKE RNYLDRDPLG VSLNALPLDT DSQFHFMELK
4010 4020 4030 4040 4050
RLALKAGDPC CNEVAINTLE ERLSDRAYEL ARGQIAEDLS DLISAPRGIP
4060 4070 4080 4090 4100
VSLLHPHNDP EFHEMVVSVR LLKRDSQPDL SKLMRLVDDL NRRVKELADC
4110 4120 4130 4140 4150
AVGTCRRKLN PLPDGIPLQS LPLDEDPLFS QMERDLVSLF LEDEKKNATR
4160 4170 4180 4190 4200
ITKLEDRLNE RAANIAVSVK AKDLEQLEQT PCGIPIELLR PHEDSTFASL
4210 4220 4230 4240 4250
ANQYRISKHL GGSDSHGVNV GTLNKRATEI AIELLRGDQS YIDRQPCGVP
4260 4270 4280 4290 4300
FSALELEKDP QFRDLQVQRM RMVLSNPKRN LNRITELEVQ LNSYVQRCAQ
4310 4320 4330 4340 4350
AFLAADRGFV DKEPGGVPLA ELDLDNDPLF HRMEVERAKL KIREPVINAY
4360 4370 4380 4390 4400
RIRNLEEKLN DRAHELAEEL LATDLEGIAP EPEGVLLASL HPHDDAECAS
4410 4420 4430 4440 4450
LIAAKRRLLK EPSQNMEKIR DVQEKLNNRV FQLAREVISK LRKQLVQEPE
4460 4470 4480 4490 4500
GIPLEFLPLD ADNTFRSMER DLLALQATPR RNDIKVETLR GSLNERACEL
4510 4520 4530 4540 4550
ARGQIQCGRG FLNPQPEGVD LEHLPLDENV VFRSKEVERT KLKRCPHENA
4560 4570 4580 4590 4600
AAITQLESDL NALVHSIAKD IKLSDRAFLN LTSHGIPREL LPLDEDRSFT
4610 4620 4630 4640 4650
TMERRRRRLK RDGNRRATAM MNLEEMMQDR VDDLAFRILR GDRGNYVTLP
4660 4670 4680 4690 4700
DGIDAADIPI DTDERFGTLE LRRAVVMLQG SDDCKEQVGK LEHQMSERLQ
4710 4720 4730 4740 4750
ELVRKRVKED RDFLDPEPEG IPLKDIPLDS DAEFRHLEAR RRKIRRESRR
4760 4770 4780 4790 4800
RVTNVADLEE AMNDRAHVLA RCIVAEDVGH LRPDYRRIPT NELHLHNDDT
4810 4820 4830 4840 4850
FRSLASKRRE LLQVGAVTVD IAAIEDDMDI RALQVADDVV AEERAFLDPQ
4860 4870 4880 4890 4900
PGGMFIVDLQ LDEDETFFAL ERERRRMRKD FRFAKRNKEA INDLEVSLNE
4910 4920 4930 4940 4950
RACELAREAF SKQRDFMDQE PEGIPLKELP LDNDLIFKDA EISRYVLLKD
4960 4970 4980 4990 5000
PKHAANELIA FENVMNCRAH ELAKEIIAKD RDFLDLEPDG VPREELPLDT
5010 5020 5030 5040 5050
DERFQVLAQE HFRLKRLNGN LKSTEVRVLE EKMNERLHEL AKEFLQENRS
5060 5070 5080 5090 5100
FLDSEPEGVP IADVPFRCDP TFVEIERELL KLSRNPVVPD SAKQIVRDLL
5110 5120 5130 5140 5150
NKRLHEIAAA FLKKERIFLD PEPFGLPLAC LPLNYDHILN LLERKRRALK
5160 5170 5180 5190 5200
KNGRGEIKTI RSLEEEIQDR VNVIAVEYLE MERSFLDPRP RGVPLTLLPL
5210 5220 5230 5240 5250
NGDWRFRSME VELRALRKNQ TKNRKDIEKI EGDLNLRATE LAGAFLQKHR
5260 5270 5280 5290 5300
VFIDPEPLGV PIEELPLDSD SIFHNMESMY LQMGRDIPRA AELRRMEEEM
5310 5320 5330 5340 5350
NDRVRELATE HLQGERAFLN QKPQGIPLCD LSLNNDRPFR DMEKRLRALR
5360 5370 5380 5390 5400
KHPRSNTEGI KTIQDEMNQR VNALARRKIS DDRSYLPLEL HGVPVYDIPL
5410 5420 5430 5440 5450
DDDREFRDLE IKRHRDKNLS PEDAVLVQRV EEELVSRALD IAKDFVSRER
5460 5470 5480 5490 5500
SFLDSNPQGV PIIRLPLSTD EQFRELETRR RHLKKDPRNA GIVALLEQQL
5510 5520 5530 5540 5550
RARAHELAEG LLGWQDVQFH EANHSVAEMW PRIGELYPEG IRNSVFPEIT
5560 5570 5580 5590 5600
QPGDTSSAPG ELGYLAPFIA ALSQHPPLIH RLLETKTHPV NGPYSFIFFD
5610 5620 5630 5640 5650
PNSNPVRVDI DDRVPVDAKC EPKFTRVPHR SWYPLLLEKA YAKFVGGYAK
5660 5670 5680 5690 5700
LDQCTPHETL RDLTGRPVLH IPFDDRLADA ANTGDFRSVK FWKGIKRNLA
5710 5720 5730 5740 5750
AGDVITCISN HESVDGLHSQ CSYALLSVIE TVHESNDVSD IVIKLHNCYY
5760 5770 5780 5790
DSPTYDGPLC NDDDNWTDGL KRLCHYNPEE DALYIPVPVF LRNFSSMQR
Length:5,799
Mass (Da):660,710
Last modified:November 22, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i748A92B5B9F334D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei5799Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH464491 Genomic DNA Translation: EAN79092.1

NCBI Reference Sequences

More...
RefSeqi
XP_828204.1, XM_823111.1

Genome annotation databases

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
Tb927.11.1130:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3665539

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tbr:Tb11.47.0035

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH464491 Genomic DNA Translation: EAN79092.1
RefSeqiXP_828204.1, XM_823111.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiQ387D9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiTb927.11.1130:pep
GeneIDi3665539
KEGGitbr:Tb11.47.0035

Organism-specific databases

EuPathDBiTriTrypDB:Tb927.11.1130

Phylogenomic databases

HOGENOMiHOG000258182
InParanoidiQ387D9

Family and domain databases

InterProiView protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR036213 Calpain_III_sf
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 3 hits
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 2 hits
SSF54001 SSF54001, 3 hits
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ387D9_TRYB2
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q387D9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: May 8, 2019
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again