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UniProtKB - Q38707 (MTDH_APIGR)
Protein
Mannitol dehydrogenase
Gene
MTD
Organism
Apium graveolens (Celery)
Status
Functioni
Oxidizes mannitol to mannose. Provides the initial step by which translocated mannitol is committed to central metabolism and, by regulating mannitol pool size, is important in regulating salt tolerance at the cellular level.
Catalytic activityi
- EC:1.1.1.255
Cofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 50 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 72 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 103 | Zinc 2By similarity | 1 | |
Metal bindingi | 106 | Zinc 2By similarity | 1 | |
Metal bindingi | 109 | Zinc 2By similarity | 1 | |
Metal bindingi | 117 | Zinc 2By similarity | 1 | |
Metal bindingi | 166 | Zinc 1; catalyticBy similarity | 1 |
GO - Molecular functioni
- mannitol dehydrogenase activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, NAD, Zinc |
Enzyme and pathway databases
BRENDAi | 1.1.1.255, 388 |
Names & Taxonomyi
Protein namesi | Recommended name: Mannitol dehydrogenase (EC:1.1.1.255)Alternative name(s): NAD-dependent mannitol dehydrogenase |
Gene namesi | Name:MTD |
Organismi | Apium graveolens (Celery) |
Taxonomic identifieri | 4045 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › campanulids › Apiales › Apiaceae › Apioideae › apioid superclade › Apieae › Apium |
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000160807 | 1 – 365 | Mannitol dehydrogenaseAdd BLAST | 365 |
Family & Domainsi
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH-like_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q38707-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKSSEIEHP VKAFGWAARD TTGLLSPFKF SRRATGEKDV RLKVLFCGVC
60 70 80 90 100
HSDHHMIHNN WGFTTYPIVP GHEIVGVVTE VGSKVEKVKV GDNVGIGCLV
110 120 130 140 150
GSCRSCESCC DNRESHCENT IDTYGSIYFD GTMTHGGYSD TMVADEHFIL
160 170 180 190 200
RWPKNLPLDS GAPLLCAGIT TYSPLKYYGL DKPGTKIGVV GLGGLGHVAV
210 220 230 240 250
KMAKAFGAQV TVIDISESKR KEALEKLGAD SFLLNSDQEQ MKGARSSLDG
260 270 280 290 300
IIDTVPVNHP LAPLFDLLKP NGKLVMVGAP EKPFELPVFS LLKGRKLLGG
310 320 330 340 350
TINGGIKETQ EMLDFAAKHN ITADVEVIPM DYVNTAMERL VKSDVRYRFV
360
IDIANTMRTE ESLGA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 | C → S in AAC61854 (Ref. 2) Curated | 1 | |
Sequence conflicti | 120 | T → I in AAC61854 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U24561 mRNA Translation: AAC15467.1 AF067082 Genomic DNA Translation: AAC61854.1 |
Genome annotation databases
KEGGi | ag:AAC15467 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U24561 mRNA Translation: AAC15467.1 AF067082 Genomic DNA Translation: AAC61854.1 |
3D structure databases
AlphaFoldDBi | Q38707 |
SMRi | Q38707 |
ModBasei | Search... |
Genome annotation databases
KEGGi | ag:AAC15467 |
Enzyme and pathway databases
BRENDAi | 1.1.1.255, 388 |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH-like_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MTDH_APIGR | |
Accessioni | Q38707Primary (citable) accession number: Q38707 Secondary accession number(s): O82461 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |