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Entry version 66 (05 Jun 2019)
Sequence version 1 (22 Nov 2005)
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Protein
Submitted name:

Calpain-like cysteine peptidase, putative

Gene

Tb11.01.5800

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calpain-like cysteine peptidase, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:Tb11.01.5800Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri185431 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008524 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11 Scaffold 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
TriTrypDB:Tb927.11.14210

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500422185822 – 1504Sequence analysisAdd BLAST1483

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q382B6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini328 – 404Calpain catalyticInterPro annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni466 – 487DisorderedSequence analysisAdd BLAST22
Regioni1174 – 1221DisorderedSequence analysisAdd BLAST48
Regioni1278 – 1307DisorderedSequence analysisAdd BLAST30
Regioni1483 – 1504DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1450 – 1470Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1199 – 1221PolarSequence analysisAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q382B6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q382B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTIPLPLSL VYFRTVLLIT AFPCNYFACA NDTERLPPFF LCLRTASRMS
60 70 80 90 100
QRSRKVPTEG GVLSVNSGSG LAIWNELQIQ QENWGGNLGL PAREPGAVVE
110 120 130 140 150
LASTEGKIVV STDPEQRNIF KECILGLSGS VGDITCTDFE VNWKRPVEIF
160 170 180 190 200
APFRPLVHRN VTPFFDPYDT ERVIGSRVPA MTSPSRRADS KSSAAAIPLH
210 220 230 240 250
IQFPEIVTTA EFPTPEAPAT ESLAFSEEGV VGQYRKVQPL TQAYDVGLEL
260 270 280 290 300
GCAATPAEAC GSRYSTDLRR RLNQADAISR LSEPPPFVMD AFNTAIRFVE
310 320 330 340 350
SEQNILTKGN YLWELIHPHA PGTCHPVYNP YGKYVVRLFI DGYFRQVPID
360 370 380 390 400
DYLPVDALGR PFFSVTAQKE IWPALIAKAL FVALGPNRHL LFTDSEAIIA
410 420 430 440 450
CLLGEWVPQR INPRTQPATA CALLLNARKD QLYNDSDATH FSASQVLTPD
460 470 480 490 500
KDKGVSVSTQ EQCNTSPWVD NQINERPASQ SKRASRLETS FANGANSPLS
510 520 530 540 550
YDISVTNVPA VPETPVICAV GVLPHDMRKL YVIHKVVVFR DTLALKISTN
560 570 580 590 600
PPSSIIEPKE LTLDNKDEAV QGLLHHPSCG DLDQRGTGWA ASQESAVASS
610 620 630 640 650
AFWVTFEELA ESLDIIIWRQ LGQESPFTFN SRITYTDTSS HPRKKGAASA
660 670 680 690 700
AAAATTVARQ TVVRWMHISS KAPEQIAIVN LGGSASCRAA SAVIGSPTPS
710 720 730 740 750
LLAAAHQTPA LSMMGSESSQ LKALSGEGRE VHLDLYRWDR GDVLCRAASF
760 770 780 790 800
ACEPSRLECM LHTVPAGSHV FRVTVVGLEP QEVVGLFSTR NFILGDEKEA
810 820 830 840 850
LRSANIFKMS DAGAHPGVEK PNEEVIWFKH RFAVKEPTIV SFVLSTLESG
860 870 880 890 900
EELSMYRDMP GASGKESKGV KTRNTNVRLH SKEAAEGSPP RGAHAEIIPY
910 920 930 940 950
CNVLLVDLDA GTSKRGAVGH LVRQRIEPNQ RGYLVMAYAL VEADSISFSL
960 970 980 990 1000
KPADLCADSP LEYGSPREKE TNGLSPCGDK GPLTPFGVRP HLFSKGWWRL
1010 1020 1030 1040 1050
VVLSSVPLDS YRAIPKDTWS FAEKGQLKQG SNALLFSYAC TVSDRTDITL
1060 1070 1080 1090 1100
LLDVHSQRPI PFRIKIFRAG VEGPPVFVSE ECVNHLFVPH VAVDVPEKVK
1110 1120 1130 1140 1150
NVAYIIEAWL DKEKVEEWER MRRLSQELKF LLAAEAARVK AEMKQQKELQ
1160 1170 1180 1190 1200
EYHEDPRAFK ERLLNQEMGP VENLVPTPLR EQMSVSSKKG RPSVDKRRTL
1210 1220 1230 1240 1250
SNAAPSRQTI VRTSVTPSTP ASAVAVHIDS IDPELVVTYD LRLYFSAKTD
1260 1270 1280 1290 1300
VKCVATGKDP LTTMRGLWVP PIDPLFGEAP PLSGGRSGGQ RGKQKDSSPS
1310 1320 1330 1340 1350
PEELYKADQG RLSRQNFLEN PRNLLFPYLP QGEKIRGVEE SAPNALASTP
1360 1370 1380 1390 1400
SIALVVGVED EPNFLHAPIL DESAHRVQHF SLYATEVVPP THGSPTQSAS
1410 1420 1430 1440 1450
GVPFLRTRSP NGRIAPPTFG NNPPPTDDDA LAIELKTPVN EVCLWLGEEL
1460 1470 1480 1490 1500
RRQEERRAEC RNGIKTLMRE YWETRKPGAA VLALPHARED EGNKRPRPRS

KMSS
Length:1,504
Mass (Da):165,627
Last modified:November 22, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4EB4AFD69FF9C488
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH464491 Genomic DNA Translation: EAN80365.1

NCBI Reference Sequences

More...
RefSeqi
XP_829477.1, XM_824384.1

Genome annotation databases

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
Tb927.11.14210:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3665185

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tbr:Tb11.01.5800

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH464491 Genomic DNA Translation: EAN80365.1
RefSeqiXP_829477.1, XM_824384.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiQ382B6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiTb927.11.14210:pep
GeneIDi3665185
KEGGitbr:Tb11.01.5800

Organism-specific databases

EuPathDBiTriTrypDB:Tb927.11.14210

Phylogenomic databases

InParanoidiQ382B6

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ382B6_TRYB2
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q382B6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 5, 2019
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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