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Protein

Lysozyme

Gene

17

Organism
Escherichia phage P1 (Bacteriophage P1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.By similarity

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei42Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH24 Glycoside Hydrolase Family 24

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Protein gp17
Gene namesi
Name:17
Synonyms:lysa, lyz
OrganismiEscherichia phage P1 (Bacteriophage P1)
Taxonomic identifieri10678 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeP1virus
Virus hostiEnterobacteriaceae [TaxID: 543]
Proteomesi
  • UP000008091 Componenti: Genome

Pathology & Biotechi

Chemistry databases

DrugBankiDB04272 Citric Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002180991 – 185LysozymeAdd BLAST185

Proteomic databases

PRIDEiQ37875

Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ37875
SMRiQ37875
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ37875

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.Curated

Phylogenomic databases

KOiK01185
OrthoDBiVOG090000CE

Family and domain databases

CDDicd00737 endolysin_autolysin, 1 hit
InterProiView protein in InterPro
IPR033907 Endolysin_autolysin
IPR002196 Glyco_hydro_24
IPR023346 Lysozyme-like_dom_sf
PfamiView protein in Pfam
PF00959 Phage_lysozyme, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit

Sequencei

Sequence statusi: Complete.

Q37875-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGKTAAGGG AICAIAVMIT IVMGNGNVRT NQAGLELIGN AEGCRRDPYM
60 70 80 90 100
CPAGVWTDGI GNTHGVTPGV RKTDQQIAAD WEKNILIAER CINQHFRGKD
110 120 130 140 150
MPDNAFSAMT SAAFNMGCNS LRTYYSKARG MRVETSIHKW AQKGEWVNMC
160 170 180
NHLPDFVNSN GVPLRGLKIR REKERQLCLT GLVNE
Length:185
Mass (Da):20,256
Last modified:November 1, 1996 - v1
Checksum:i8F7CA469850049B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87673 Genomic DNA Translation: CAA61013.1
AF125376 Genomic DNA Translation: AAD20630.1
AF234172 Genomic DNA Translation: AAQ13989.1
RefSeqiYP_006484.1, NC_005856.1

Genome annotation databases

GeneIDi2777454
KEGGivg:2777454

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87673 Genomic DNA Translation: CAA61013.1
AF125376 Genomic DNA Translation: AAD20630.1
AF234172 Genomic DNA Translation: AAQ13989.1
RefSeqiYP_006484.1, NC_005856.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XJTX-ray1.75A1-185[»]
1XJUX-ray1.07A/B29-185[»]
ProteinModelPortaliQ37875
SMRiQ37875
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB04272 Citric Acid

Protein family/group databases

CAZyiGH24 Glycoside Hydrolase Family 24

Proteomic databases

PRIDEiQ37875

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2777454
KEGGivg:2777454

Phylogenomic databases

KOiK01185
OrthoDBiVOG090000CE

Miscellaneous databases

EvolutionaryTraceiQ37875

Family and domain databases

CDDicd00737 endolysin_autolysin, 1 hit
InterProiView protein in InterPro
IPR033907 Endolysin_autolysin
IPR002196 Glyco_hydro_24
IPR023346 Lysozyme-like_dom_sf
PfamiView protein in Pfam
PF00959 Phage_lysozyme, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLYS_BPP1
AccessioniPrimary (citable) accession number: Q37875
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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Main funding by: National Institutes of Health

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