UniProtKB - Q37605 (COX2_PONPY)
Protein
Cytochrome c oxidase subunit 2
Gene
MT-CO2
Organism
Pongo pygmaeus (Bornean orangutan)
Status
Functioni
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Cofactori
Cu cationNote: Binds a copper A center.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 161 | Copper ABy similarity | 1 | |
Metal bindingi | 196 | Copper ABy similarity | 1 | |
Metal bindingi | 200 | Copper ABy similarity | 1 | |
Metal bindingi | 204 | Copper ABy similarity | 1 |
GO - Molecular functioni
- copper ion binding Source: InterPro
- cytochrome-c oxidase activity Source: InterPro
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Ligand | Copper, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c oxidase subunit 2Alternative name(s): Cytochrome c oxidase polypeptide II |
Gene namesi | Name:MT-CO2 Synonyms:COII, COX2, COXII, MTCO2 |
Encoded oni | Mitochondrion |
Organismi | Pongo pygmaeus (Bornean orangutan) |
Taxonomic identifieri | 9600 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- respiratory chain complex IV Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 26 | Mitochondrial intermembraneSequence analysisAdd BLAST | 26 | |
Transmembranei | 27 – 48 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 49 – 62 | Mitochondrial matrixSequence analysisAdd BLAST | 14 | |
Transmembranei | 63 – 82 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 83 – 227 | Mitochondrial intermembraneSequence analysisAdd BLAST | 145 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183670 | 1 – 227 | Cytochrome c oxidase subunit 2Add BLAST | 227 |
Proteomic databases
PRIDEi | Q37605 |
Interactioni
Subunit structurei
Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2.
Interacts with TMEM177 in a COX20-dependent manner.
Interacts with COX20.
Interacts with COX16.
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the cytochrome c oxidase subunit 2 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | HOG000264988 |
Family and domain databases
CDDi | cd13912 CcO_II_C, 1 hit |
Gene3Di | 1.10.287.90, 1 hit 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR002429 CcO_II-like_C IPR034210 CcO_II_C IPR001505 Copper_CuA IPR008972 Cupredoxin IPR014222 Cyt_c_oxidase_su2 IPR011759 Cyt_c_oxidase_su2_TM_dom IPR036257 Cyt_c_oxidase_su2_TM_sf |
Pfami | View protein in Pfam PF00116 COX2, 1 hit PF02790 COX2_TM, 1 hit |
SUPFAMi | SSF49503 SSF49503, 1 hit SSF81464 SSF81464, 1 hit |
TIGRFAMsi | TIGR02866 CoxB, 1 hit |
PROSITEi | View protein in PROSITE PS00078 COX2, 1 hit PS50857 COX2_CUA, 1 hit PS50999 COX2_TM, 1 hit |
i Sequence
Sequence statusi: Complete.
Q37605-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAHRAQVGLQ DATSPIMEEL VIFHDHALMI IFLICFLVLY ALFLTLTTKL
60 70 80 90 100
TNTNISDAQE METIWTTLPA IILILIALPS LRILYLTDEI NDPSFTIKSI
110 120 130 140 150
GHQWYWTYEY TDYGGLIFNS YMLPPLFLEP GDLRLLDVDN RVVLPVEAPV
160 170 180 190 200
RMMITSQDVL HSWTVPSLGL KTDAIPGRLN QTTFTATRPG VYYGQCSEIC
210 220
GANHSFMPIV LELIPLKIFE MGPVFAL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019058 | 4 | R → A in strain: Isolate San Diego zoo Ppy3, Isolate Anna and Isolate Dennis. 2 Publications | 1 | |
Natural variantiVAR_019554 | 38 | V → I in strain: Isolate Anna. 1 Publication | 1 | |
Natural variantiVAR_019059 | 54 | N → S in strain: Isolate San Diego zoo Ppy3, Isolate Anna and Isolate Dennis. 1 Publication | 1 | |
Natural variantiVAR_019060 | 67 | T → I in strain: Isolate San Diego zoo Ppy3. 2 Publications | 1 | |
Natural variantiVAR_019061 | 184 | F → L in strain: Isolate San Diego zoo Ppy3. 1 Publication | 1 | |
Natural variantiVAR_019062 | 226 | A → T in strain: Isolate San Diego zoo PPY3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12703 Genomic DNA Translation: AAA61412.1 U12704 Genomic DNA Translation: AAA61413.1 D38115 Genomic DNA Translation: BAA07308.1 X97716 Genomic DNA Translation: CAA66302.1 X97712 Genomic DNA Translation: CAA66298.1 |
PIRi | I61892 T14142 |
RefSeqi | NP_008228.1, NC_001646.1 |
Genome annotation databases
GeneIDi | 807910 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12703 Genomic DNA Translation: AAA61412.1 U12704 Genomic DNA Translation: AAA61413.1 D38115 Genomic DNA Translation: BAA07308.1 X97716 Genomic DNA Translation: CAA66302.1 X97712 Genomic DNA Translation: CAA66298.1 |
PIRi | I61892 T14142 |
RefSeqi | NP_008228.1, NC_001646.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | Q37605 |
Genome annotation databases
GeneIDi | 807910 |
Organism-specific databases
CTDi | 4513 |
Phylogenomic databases
HOGENOMi | HOG000264988 |
Family and domain databases
CDDi | cd13912 CcO_II_C, 1 hit |
Gene3Di | 1.10.287.90, 1 hit 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR002429 CcO_II-like_C IPR034210 CcO_II_C IPR001505 Copper_CuA IPR008972 Cupredoxin IPR014222 Cyt_c_oxidase_su2 IPR011759 Cyt_c_oxidase_su2_TM_dom IPR036257 Cyt_c_oxidase_su2_TM_sf |
Pfami | View protein in Pfam PF00116 COX2, 1 hit PF02790 COX2_TM, 1 hit |
SUPFAMi | SSF49503 SSF49503, 1 hit SSF81464 SSF81464, 1 hit |
TIGRFAMsi | TIGR02866 CoxB, 1 hit |
PROSITEi | View protein in PROSITE PS00078 COX2, 1 hit PS50857 COX2_CUA, 1 hit PS50999 COX2_TM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COX2_PONPY | |
Accessioni | Q37605Primary (citable) accession number: Q37605 Secondary accession number(s): P92721 Q37607 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | September 18, 2019 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |