MT-CO2

Functionⁱ

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Cofactorⁱ

Cu cationNote: Binds a copper A center.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	161	Copper ABy similarity	1
Metal bindingⁱ	196	Copper ABy similarity	1
Metal bindingⁱ	200	Copper ABy similarity	1
Metal bindingⁱ	204	Copper ABy similarity	1

GO - Molecular functionⁱ

copper ion binding Source: InterPro
cytochrome-c oxidase activity Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Electron transport, Respiratory chain, Transport
Ligand	Copper, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome c oxidase subunit 2 Alternative name(s): Cytochrome c oxidase polypeptide II
Gene namesⁱ	Name:MT-CO2 Synonyms:COII, COX2, COXII, MTCO2
Encoded onⁱ	Mitochondrion
Organismⁱ	Malacothrix typica (Long-eared mouse) (Gerbil mouse)
Taxonomic identifierⁱ	37438 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Nesomyidae › Dendromurinae › Malacothrix

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 26	Mitochondrial intermembraneSequence analysisAdd BLAST	26
Transmembraneⁱ	27 – 48	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	49 – 62	Mitochondrial matrixSequence analysisAdd BLAST	14
Transmembraneⁱ	63 – 82	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	83 – 227	Mitochondrial intermembraneSequence analysisAdd BLAST	145

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000254930	1 – 227	Cytochrome c oxidase subunit 2Add BLAST		227

Interactionⁱ

Subunit structureⁱ

Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16.By similarity

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q37547
SMRⁱ	Q37547
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome c oxidase subunit 2 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENⁱ	HBG012727

HOVERGENⁱ

HBG012727

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13912 CcO_II_C, 1 hit
Gene3Dⁱ	1.10.287.90, 1 hit 2.60.40.420, 1 hit
InterProⁱ	View protein in InterPro IPR002429 CcO_II-like_C IPR034210 CcO_II_C IPR001505 Copper_CuA IPR008972 Cupredoxin IPR014222 Cyt_c_oxidase_su2 IPR011759 Cyt_c_oxidase_su2_TM_dom IPR036257 Cyt_c_oxidase_su2_TM_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00116 COX2, 1 hit PF02790 COX2_TM, 1 hit
SUPFAMⁱ	SSF49503 SSF49503, 1 hit SSF81464 SSF81464, 1 hit
TIGRFAMsⁱ	TIGR02866 CoxB, 1 hit
PROSITEⁱ	View protein in PROSITE PS00078 COX2, 1 hit PS50857 COX2_CUA, 1 hit PS50999 COX2_TM, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q37547-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAYPLQLGLQ DATSPIMEEL MNFHDHTLMI VFLISSLVLY VISSMLTTKL 
        60         70         80         90        100
THTSTMDAQE VETIWTILPA VILIMIALPS LRILYMMDEI NNPVLTVKTM 
       110        120        130        140        150
GHQWYWSYEY TDYEDLCFDS YMIPTTDLKP GEFRLLEVDN RVILPMELPI 
       160        170        180        190        200
RMLISSEDVL HSWAIPSLGL KTDAIPGRLN QATISSNRPG LFYGQCSEIC 
       210        220 
GSNHSFMPII LEMVPLKNFE TWSVSMI

Length:227

Mass (Da):25,931

Last modified:November 1, 1996 - v1

Checksum:ⁱ8A2A5E683FC9C1B5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U18834 Genomic DNA Translation: AAA75616.1
PIRⁱ	I49438

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q37547	Cytochrome c oxidase subunit 2		RHAPU		227	UniRef90_Q38RV6
Cytochrome c oxidase subunit 2		MERSH		228
Cytochrome c oxidase subunit 2		ACOIG		227
Cytochrome c oxidase subunit 2		ACOWI		227
Cytochrome c oxidase subunit 2		APOSM		227
+98

Protein	Similar proteins		Species	Score	Length	Source
Q37547	Cytochrome c oxidase subunit 2		ORNAN		230	UniRef50_Q37718
Cytochrome c oxidase subunit 2		GALVR		227
Cytochrome c oxidase subunit 2		CAVAP		227
Cytochrome c oxidase subunit 2		LOXAF		228
Cytochrome c oxidase subunit 2		ELEMA		227
+388

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U18834 Genomic DNA Translation: AAA75616.1
PIRⁱ	I49438

3D structure databases

ProteinModelPortalⁱ	Q37547
SMRⁱ	Q37547
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

HOVERGENⁱ	HBG012727

HOVERGENⁱ

HBG012727

Family and domain databases

CDDⁱ	cd13912 CcO_II_C, 1 hit
Gene3Dⁱ	1.10.287.90, 1 hit 2.60.40.420, 1 hit
InterProⁱ	View protein in InterPro IPR002429 CcO_II-like_C IPR034210 CcO_II_C IPR001505 Copper_CuA IPR008972 Cupredoxin IPR014222 Cyt_c_oxidase_su2 IPR011759 Cyt_c_oxidase_su2_TM_dom IPR036257 Cyt_c_oxidase_su2_TM_sf
Pfamⁱ	View protein in Pfam PF00116 COX2, 1 hit PF02790 COX2_TM, 1 hit
SUPFAMⁱ	SSF49503 SSF49503, 1 hit SSF81464 SSF81464, 1 hit
TIGRFAMsⁱ	TIGR02866 CoxB, 1 hit
PROSITEⁱ	View protein in PROSITE PS00078 COX2, 1 hit PS50857 COX2_CUA, 1 hit PS50999 COX2_TM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	COX2_MALTY
Accessionⁱ	Q37547Primary (citable) accession number: Q37547
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
	Last sequence update:	November 1, 1996
	Last modified:	March 28, 2018
	This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Documents

SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q37547 (COX2_MALTY)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Cytochrome c oxidase subunit 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ