UniProtKB - Q36918 (ATP6_PENCH)
ATP synthase subunit a
atp6
Functioni
Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
GO - Molecular functioni
- proton transmembrane transporter activity Source: InterPro
GO - Biological processi
- ATP synthesis coupled proton transport Source: InterPro
Keywordsi
Biological process | ATP synthesis, Hydrogen ion transport, Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: ATP synthase subunit aAlternative name(s): F-ATPase protein 6 |
Gene namesi | Name:atp6 |
Encoded oni | Mitochondrion |
Organismi | Penicillium chrysogenum (Penicillium notatum) |
Taxonomic identifieri | 5076 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Penicillium › Penicillium chrysogenum species complex |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- proton-transporting ATP synthase complex, coupling factor F(o) Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 93 – 113 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 122 – 142 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 187 – 207 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 210 – 230 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 231 – 251 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
CF(0), Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000002618 | 1 – 8 | Removed in mature formBy similarity | 8 | |
ChainiPRO_0000002619 | 9 – 257 | ATP synthase subunit aAdd BLAST | 249 |
Interactioni
Subunit structurei
F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 1.20.120.220, 1 hit |
HAMAPi | MF_01393, ATP_synth_a_bact, 1 hit |
InterProi | View protein in InterPro IPR000568, ATP_synth_F0_asu IPR023011, ATP_synth_F0_asu_AS IPR045083, ATP_synth_F0_asu_bact/mt IPR035908, F0_ATP_A_sf |
PANTHERi | PTHR11410, PTHR11410, 1 hit |
Pfami | View protein in Pfam PF00119, ATP-synt_A, 1 hit |
PRINTSi | PR00123, ATPASEA |
SUPFAMi | SSF81336, SSF81336, 1 hit |
TIGRFAMsi | TIGR01131, ATP_synt_6_or_A, 1 hit |
PROSITEi | View protein in PROSITE PS00449, ATPASE_A, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MRHLDFVLSP LDQFEVRDLF SLNANLLGNL HLSLTNIGLY LTISIFLILT
60 70 80 90 100
YSLLATNNNK IIPNNWSISQ ESIYATVHGI VVNQINPNKG QMFFPLMYVL
110 120 130 140 150
FIFILVNNLI GLVPYSFAST SHFILTFSIS FTVVLGATIL GFQRHGLKFF
160 170 180 190 200
SLFVPSGCPL ALLPLLVLIE FISYLSRNVS LGLRLAANIL SGHMLLSILS
210 220 230 240 250
GFTYNIMTSG IIFFILGLIP LAFIIAFSGL ELAIAFIQAQ VFVVLACSYI
KDGLDLH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z23072 Genomic DNA Translation: CAA80613.1 L19866 Genomic DNA Translation: AAA58774.2 |
PIRi | S42271 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z23072 Genomic DNA Translation: CAA80613.1 L19866 Genomic DNA Translation: AAA58774.2 |
PIRi | S42271 |
3D structure databases
SMRi | Q36918 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 1.20.120.220, 1 hit |
HAMAPi | MF_01393, ATP_synth_a_bact, 1 hit |
InterProi | View protein in InterPro IPR000568, ATP_synth_F0_asu IPR023011, ATP_synth_F0_asu_AS IPR045083, ATP_synth_F0_asu_bact/mt IPR035908, F0_ATP_A_sf |
PANTHERi | PTHR11410, PTHR11410, 1 hit |
Pfami | View protein in Pfam PF00119, ATP-synt_A, 1 hit |
PRINTSi | PR00123, ATPASEA |
SUPFAMi | SSF81336, SSF81336, 1 hit |
TIGRFAMsi | TIGR01131, ATP_synt_6_or_A, 1 hit |
PROSITEi | View protein in PROSITE PS00449, ATPASE_A, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ATP6_PENCH | |
Accessioni | Q36918Primary (citable) accession number: Q36918 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |