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Protein

Decaprenyl-diphosphate synthase subunit 2

Gene

Pdss2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.1 Publication

Catalytic activityi

(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate.1 Publication

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • isoprenoid biosynthetic process Source: HGNC
  • protein heterotetramerization Source: MGI
  • regulation of body fluid levels Source: MGI
  • ubiquinone biosynthetic process Source: HGNC

Keywordsi

Molecular functionTransferase
Biological processIsoprene biosynthesis, Ubiquinone biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-2142789 Ubiquinol biosynthesis
UniPathwayi
UPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
Decaprenyl-diphosphate synthase subunit 2 (EC:2.5.1.91)
Alternative name(s):
All-trans-decaprenyl-diphosphate synthase subunit 2
Decaprenyl pyrophosphate synthase subunit 2
Solanesyl-diphosphate synthase subunit 2
Gene namesi
Name:Pdss2
Synonyms:Dlp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1918615 Pdss2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001239791 – 401Decaprenyl-diphosphate synthase subunit 2Add BLAST401

Proteomic databases

EPDiQ33DR3
MaxQBiQ33DR3
PaxDbiQ33DR3
PeptideAtlasiQ33DR3
PRIDEiQ33DR3

PTM databases

PhosphoSitePlusiQ33DR3

Expressioni

Gene expression databases

BgeeiENSMUSG00000038240 Expressed in 201 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiQ33DR3 baseline and differential
GenevisibleiQ33DR3 MM

Interactioni

Subunit structurei

Heterotetramer of 2 DPS1/TPRT and 2 DLP1 subunits.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093393

Structurei

3D structure databases

ProteinModelPortaliQ33DR3
SMRiQ33DR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

eggNOGiKOG0776 Eukaryota
COG0142 LUCA
GeneTreeiENSGT00530000063378
HOGENOMiHOG000294216
HOVERGENiHBG058860
InParanoidiQ33DR3
KOiK12505
OMAiIYPSQRN
OrthoDBiEOG091G0B45
PhylomeDBiQ33DR3
TreeFamiTF354277

Family and domain databases

Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR000092 Polyprenyl_synt
PfamiView protein in Pfam
PF00348 polyprenyl_synt, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q33DR3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLRQLLLRL SGYLGASGPP SRHWWYFRSL DSISSAGSWR GRSSRSPAHW
60 70 80 90 100
NQVVSEAEKI VGYPASFMSL RCLLSDELSN IAMQVRKLVG TGHPLLTTAR
110 120 130 140 150
ALVHDSRHNL QLRGLVVLLI SKAAGPSTRN AACQNYDMVS GVYSCQRSLA
160 170 180 190 200
EITELIHTAL LVHRGIVNLS ELQSSDGPLK DMQFGNKIAI LSGDFLLANA
210 220 230 240 250
CNGLALLQNT KVVELLSSAL MDLVHGVYQE NSASTKENSI PDDIGISTWK
260 270 280 290 300
EQTFLSHCAL LAKSCQAAME LAKHDAAVQD MAFQYGKHMA MSHKINADLQ
310 320 330 340 350
PFIKDKASDS KTFNLNSAPV VLHQEFLGRD LWIKQIGEAQ EKGSLNYSKL
360 370 380 390 400
RETIKAGKGV TSAIDLCRYH GNKALEALES FPPSEARSAL ENIVFAVTRF

S
Length:401
Mass (Da):43,980
Last modified:January 24, 2006 - v2
Checksum:iDB7835A83019E5AA
GO
Isoform 2 (identifier: Q33DR3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     350-352: LRE → VVS
     353-401: Missing.

Note: No experimental confirmation available.
Show »
Length:352
Mass (Da):38,618
Checksum:i22895FB1C1B55490
GO
Isoform 3 (identifier: Q33DR3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-264: VELLSSALMD...LSHCALLAKS → KAERLTCAHT...DGDLGSDNMK
     265-401: Missing.

Show »
Length:264
Mass (Da):28,599
Checksum:iEDE79A90E66D6F6E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CYM9E0CYM9_MOUSE
Decaprenyl-diphosphate synthase sub...
Pdss2
348Annotation score:
F6T4Z4F6T4Z4_MOUSE
Decaprenyl-diphosphate synthase sub...
Pdss2
138Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132A → S in BAE48218 (PubMed:16262699).Curated1
Sequence conflicti204L → I in BAB30693 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017102213 – 264VELLS…LLAKS → KAERLTCAHTASGVSCLAAE ATDRGVCVLLLSSSMWMLTE TDDGDLGSDNMK in isoform 3. 2 PublicationsAdd BLAST52
Alternative sequenceiVSP_017103265 – 401Missing in isoform 3. 2 PublicationsAdd BLAST137
Alternative sequenceiVSP_017104350 – 352LRE → VVS in isoform 2. 1 Publication3
Alternative sequenceiVSP_017105353 – 401Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210840 mRNA Translation: BAE48218.1
AK017329 mRNA Translation: BAB30693.1
AK140091 mRNA Translation: BAE24234.1
BC147693 mRNA Translation: AAI47694.1
BC147694 mRNA Translation: AAI47695.1
BC147752 mRNA Translation: AAI47753.1
BC147753 mRNA Translation: AAI47754.1
CCDSiCCDS35891.1 [Q33DR3-1]
CCDS48552.1 [Q33DR3-2]
RefSeqiNP_001161761.1, NM_001168289.1 [Q33DR3-2]
NP_082048.2, NM_027772.2 [Q33DR3-1]
UniGeneiMm.490430

Genome annotation databases

EnsembliENSMUST00000095725; ENSMUSP00000093393; ENSMUSG00000038240 [Q33DR3-1]
ENSMUST00000159139; ENSMUSP00000124864; ENSMUSG00000038240 [Q33DR3-2]
GeneIDi71365
KEGGimmu:71365
UCSCiuc007ezh.2 mouse [Q33DR3-3]
uc007ezi.2 mouse [Q33DR3-1]
uc011xdk.1 mouse [Q33DR3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210840 mRNA Translation: BAE48218.1
AK017329 mRNA Translation: BAB30693.1
AK140091 mRNA Translation: BAE24234.1
BC147693 mRNA Translation: AAI47694.1
BC147694 mRNA Translation: AAI47695.1
BC147752 mRNA Translation: AAI47753.1
BC147753 mRNA Translation: AAI47754.1
CCDSiCCDS35891.1 [Q33DR3-1]
CCDS48552.1 [Q33DR3-2]
RefSeqiNP_001161761.1, NM_001168289.1 [Q33DR3-2]
NP_082048.2, NM_027772.2 [Q33DR3-1]
UniGeneiMm.490430

3D structure databases

ProteinModelPortaliQ33DR3
SMRiQ33DR3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093393

PTM databases

PhosphoSitePlusiQ33DR3

Proteomic databases

EPDiQ33DR3
MaxQBiQ33DR3
PaxDbiQ33DR3
PeptideAtlasiQ33DR3
PRIDEiQ33DR3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095725; ENSMUSP00000093393; ENSMUSG00000038240 [Q33DR3-1]
ENSMUST00000159139; ENSMUSP00000124864; ENSMUSG00000038240 [Q33DR3-2]
GeneIDi71365
KEGGimmu:71365
UCSCiuc007ezh.2 mouse [Q33DR3-3]
uc007ezi.2 mouse [Q33DR3-1]
uc011xdk.1 mouse [Q33DR3-2]

Organism-specific databases

CTDi57107
MGIiMGI:1918615 Pdss2

Phylogenomic databases

eggNOGiKOG0776 Eukaryota
COG0142 LUCA
GeneTreeiENSGT00530000063378
HOGENOMiHOG000294216
HOVERGENiHBG058860
InParanoidiQ33DR3
KOiK12505
OMAiIYPSQRN
OrthoDBiEOG091G0B45
PhylomeDBiQ33DR3
TreeFamiTF354277

Enzyme and pathway databases

UniPathwayi
UPA00232

ReactomeiR-MMU-2142789 Ubiquinol biosynthesis

Miscellaneous databases

ChiTaRSiPdss2 mouse
PROiPR:Q33DR3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038240 Expressed in 201 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiQ33DR3 baseline and differential
GenevisibleiQ33DR3 MM

Family and domain databases

Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR000092 Polyprenyl_synt
PfamiView protein in Pfam
PF00348 polyprenyl_synt, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDLP1_MOUSE
AccessioniPrimary (citable) accession number: Q33DR3
Secondary accession number(s): B2RWA7
, B2RWF3, Q3USU6, Q9D3K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: September 12, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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