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Protein

Inositol-tetrakisphosphate 1-kinase 1

Gene

ITPK1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 and participates in phytic acid biosynthesis in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.By similarity

Catalytic activityi

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.Curated
ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.Curated
ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate.Curated

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei531D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei951D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei130ATPBy similarity1
Binding sitei180ATPBy similarity1
Binding sitei1911D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei2231D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei238ATPBy similarity1
Metal bindingi303Magnesium 1By similarity1
Metal bindingi318Magnesium 1By similarity1
Metal bindingi318Magnesium 2By similarity1
Metal bindingi320Magnesium 2By similarity1
Binding sitei3201D-myo-inositol 1,3,4-trisphosphateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi212 – 223ATPBy similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-1855167 Synthesis of pyrophosphates in the cytosol
R-OSA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-OSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-tetrakisphosphate 1-kinase 1Curated (EC:2.7.1.134Curated)
Alternative name(s):
Inositol 1,3,4-trisphosphate 5/6-kinase 1Curated (EC:2.7.1.159Curated)
Short name:
Inositol-triphosphate 5/6-kinase 1Curated
Short name:
Ins(1,3,4)P(3) 5/6-kinase 1Curated
Short name:
OsITP5/6K-11 Publication
Short name:
OsITPK11 Publication
OsITL2Curated
Gene namesi
Name:ITPK1Curated
Ordered Locus Names:Os10g0103800Imported, LOC_Os10g01480Imported
ORF Names:OsJ_30457Imported, OSJNBa0071K19.6Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 10

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004318691 – 354Inositol-tetrakisphosphate 1-kinase 1Add BLAST354

Proteomic databases

PaxDbiQ33BI9

Expressioni

Tissue specificityi

Expressed in roots, leaves, flowers, anthers and embryos.1 Publication

Inductioni

By drought stress.1 Publication

Gene expression databases

ExpressionAtlasiQ33BI9 differential
GenevisibleiQ33BI9 OS

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os10g01480.1

Structurei

3D structure databases

SMRiQ33BI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini140 – 347ATP-graspPROSITE-ProRule annotationAdd BLAST208

Sequence similaritiesi

Belongs to the ITPK1 family.Curated

Phylogenomic databases

eggNOGiENOG410IHA6 Eukaryota
ENOG4110KIK LUCA
KOiK00913
OMAiENSANRF
OrthoDBiEOG09360GWF

Family and domain databases

InterProiView protein in InterPro
IPR008656 Inositol_tetrakis-P_1-kinase
PANTHERiPTHR14217 PTHR14217, 1 hit
PfamiView protein in Pfam
PF05770 Ins134_P3_kin, 1 hit
PIRSFiPIRSF038186 ITPK, 1 hit

Sequencei

Sequence statusi: Complete.

Q33BI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVHEEASED KEREVEEAPD LMPLSPPLTA AATAAVVAVA GQRLVVGYAL
60 70 80 90 100
TKKKVKSFLQ PKLLSLARKK SIHFVSIDET RPLSEQGPFD IILHKLTDKE
110 120 130 140 150
WQQVLEDYRE EHPEVTVLDP PNAIQHLHNR QSMLQEVADL NLSNAYGEVC
160 170 180 190 200
TPRQLVIMKD PLSIPSAVAK AGLTLPLVAK PLVVDGTSKS HELSLAYVET
210 220 230 240 250
SLSMLDPPLV LQEFVNHGGI LFKVYVVGET IRVVRRFSLP DVNIYDLENN
260 270 280 290 300
DGIFRFPRVS CATNTAEDAE VDPSIAELPP KPLLEKLGRE LRRRLGLRLF
310 320 330 340 350
NFDMIREHGR KDRYYVIDIN YFPGYGKMPG YEHIFIDFLL SLVQNKYKRR

LSGS
Length:354
Mass (Da):40,002
Last modified:December 6, 2005 - v1
Checksum:iC7AEEA4A5CACF2D1
GO

Sequence cautioni

The sequence AAK00417 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069324 Genomic DNA Translation: AAK00417.2 Different initiation.
DP000086 Genomic DNA Translation: ABB46580.1
AP008216 Genomic DNA Translation: BAF25933.1
AP014966 Genomic DNA Translation: BAT09582.1
CM000147 Genomic DNA Translation: EEE50447.1
AK106544 mRNA Translation: BAG97757.1
RefSeqiXP_015615026.1, XM_015759540.1
UniGeneiOs.46870

Genome annotation databases

EnsemblPlantsiOs10t0103800-01; Os10t0103800-01; Os10g0103800
GeneIDi4347947
GrameneiOs10t0103800-01; Os10t0103800-01; Os10g0103800
KEGGiosa:4347947

Similar proteinsi

Entry informationi

Entry nameiITPK1_ORYSJ
AccessioniPrimary (citable) accession number: Q33BI9
Secondary accession number(s): A0A0P0XRB9, Q9AYJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 4, 2015
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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